P
Pei-Lun Chu
Researcher at Fu Jen Catholic University
Publications - 25
Citations - 796
Pei-Lun Chu is an academic researcher from Fu Jen Catholic University. The author has contributed to research in topics: Genome-wide association study & Kidney disease. The author has an hindex of 13, co-authored 22 publications receiving 633 citations. Previous affiliations of Pei-Lun Chu include University of Virginia Health System & National Taiwan University.
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Journal ArticleDOI
Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations
Jingjing Liang,Thu H. Le,Digna R. Velez Edwards,Bamidele O. Tayo,Kyle J. Gaulton,Jennifer A. Smith,Yingchang Lu,Yingchang Lu,Richard A. Jensen,Guanjie Chen,Lisa R. Yanek,Karen Schwander,Salman M. Tajuddin,Tamar Sofer,Wonji Kim,James Kayima,Colin A. McKenzie,Ervin R. Fox,Mike A. Nalls,J. Hunter Young,Yan V. Sun,Jacqueline M. Lane,Jacqueline M. Lane,Sylvia Cechova,Jie Zhou,Hua Tang,Myriam Fornage,Solomon K. Musani,Heming Wang,Juyoung Lee,Adebowale Adeyemo,Albert W. Dreisbach,Terrence Forrester,Pei-Lun Chu,Anne R. Cappola,Michele K. Evans,Alanna C. Morrison,Lisa W. Martin,Kerri L. Wiggins,Qin Hui,Wei Zhao,Rebecca D. Jackson,Erin B. Ware,Jessica D. Faul,Alexander P. Reiner,Michael J. Bray,Joshua C. Denny,Thomas H. Mosley,Walter Palmas,Xiuqing Guo,George J. Papanicolaou,Alan D. Penman,Joseph F. Polak,Kenneth Rice,K. D. Taylor,Eric Boerwinkle,Erwin P. Bottinger,Kiang Liu,Neil Risch,Steven C. Hunt,Charles Kooperberg,Alan B. Zonderman,Cathy C. Laurie,Diane M. Becker,Jianwen Cai,Ruth J. F. Loos,Bruce M. Psaty,Bruce M. Psaty,David R. Weir,Sharon L.R. Kardia,Donna K. Arnett,Sungho Won,Todd L. Edwards,Susan Redline,Richard S. Cooper,Dabeeru C. Rao,Jerome I. Rotter,Charles N. Rotimi,Daniel Levy,Aravinda Chakravarti,Xiaofeng Zhu,Nora Franceschini +81 more
TL;DR: This study provides new evidence for genes related to hypertension susceptibility, and the need to study African-ancestry populations in order to identify biologic factors contributing to hypertension.
Journal ArticleDOI
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies
Andrew P. Morris,Andrew P. Morris,Thu H Le,Haojia Wu,Artur Akbarov,Peter J. van der Most,Gibran Hemani,George Davey Smith,Anubha Mahajan,Kyle J. Gaulton,Girish N. Nadkarni,Adan Valladares-Salgado,Niels Wacher-Rodarte,Josyf C. Mychaleckyj,Nicole Dueker,Xiuqing Guo,Yang Hai,Jeff Haessler,Yoichiro Kamatani,Adrienne M. Stilp,Gu Zhu,James P. Cook,Johan Ärnlöv,Johan Ärnlöv,Susan H. Blanton,Martin H. de Borst,Erwin P. Bottinger,Thomas A. Buchanan,Sylvia Cechova,Fadi J. Charchar,Fadi J. Charchar,Fadi J. Charchar,Pei-Lun Chu,Jeffrey Damman,James Eales,Ali G. Gharavi,Vilmantas Giedraitis,Andrew C. Heath,Eli Ipp,Eli Ipp,Krzysztof Kiryluk,Holly Kramer,Michiaki Kubo,Anders Larsson,Cecilia M. Lindgren,Cecilia M. Lindgren,Yingchang Lu,Pamela A. F. Madden,Grant W. Montgomery,George Papanicolaou,Leslie J. Raffel,Ralph L. Sacco,Ralph L. Sacco,Elena Sanchez,Holger Stark,Johan Sundström,Kent D. Taylor,Anny H. Xiang,Aleksandra Zivkovic,Lars Lind,Erik Ingelsson,Erik Ingelsson,Nicholas G. Martin,John Whitfield,Jianwen Cai,Cathy C. Laurie,Yukinori Okada,Koichi Matsuda,Charles Kooperberg,Yii-Der Ida Chen,Tatjana Rundek,Stephen S. Rich,Ruth J. F. Loos,Esteban J. Parra,Miguel Cruz,Jerome I. Rotter,Harold Snieder,Maciej Tomaszewski,Benjamin D. Humphreys,Nora Franceschini +79 more
TL;DR: Trans-ethnic genome-wide meta-analyses for eGFR in 312,468 individuals are performed and novel loci and downstream putative causal genes are identified, offering insight into clinical outcomes and routes to CKD treatment development.
Journal ArticleDOI
Association among total serum isomers of perfluorinated chemicals, glucose homeostasis, lipid profiles, serum protein and metabolic syndrome in adults: NHANES, 2013–2014☆
TL;DR: S serum isomers of PFOA and PFOS were associated with glucose homeostasis, serum protein as well as lipid profiles; they were also indicators of MS, which may suggest that there is a distinct difference in the toxicokinetics of the isomers.
Journal ArticleDOI
Tnni3k Modifies Disease Progression in Murine Models of Cardiomyopathy
Ferrin C. Wheeler,Hao Tang,Odessa A. Marks,Tracy N. Hadnott,Pei-Lun Chu,Lan Mao,Howard A. Rockman,Douglas A. Marchuk +7 more
TL;DR: Tnni3k (cardiac Troponin I-interacting kinase) is reported as the gene underlying Hrtfm2, which plays a critical role in the modulation of different forms of heart disease and this protein may provide a novel target for therapeutic intervention.
Journal ArticleDOI
Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity.
Anubha Mahajan,Aylin R. Rodan,Thu H. Le,Kyle J. Gaulton,Jeffrey Haessler,Adrienne M. Stilp,Yoichiro Kamatani,Gu Zhu,Tamar Sofer,Sanjana Puri,Jeffrey N. Schellinger,Pei-Lun Chu,Sylvia Cechova,Natalie van Zuydam,Johan Ärnlöv,Johan Ärnlöv,Michael F. Flessner,Vilmantas Giedraitis,Andrew C. Heath,Michiaki Kubo,Anders Larsson,Cecilia M. Lindgren,Cecilia M. Lindgren,Pamela A. F. Madden,Grant W. Montgomery,George J. Papanicolaou,Alexander P. Reiner,Johan Sundström,Timothy A. Thornton,Lars Lind,Erik Ingelsson,Erik Ingelsson,Jianwen Cai,Nicholas G. Martin,Charles Kooperberg,Koichi Matsuda,John Whitfield,Yukinori Okada,Cathy C. Laurie,Andrew P. Morris,Andrew P. Morris,Nora Franceschini +41 more
TL;DR: The utility of trans-ethnic fine mapping through integration of GWASs involving diverse populations with genomic annotation from relevant tissues to define molecular mechanisms by which association signals exert their effect is demonstrated and salt sensitivity might be an important marker for biological processes that affect kidney function and CKD in humans is suggested.