J
Jerome I. Rotter
Researcher at UCLA Medical Center
Publications - 20
Citations - 587
Jerome I. Rotter is an academic researcher from UCLA Medical Center. The author has contributed to research in topics: Genome-wide association study & Mendelian randomization. The author has an hindex of 11, co-authored 20 publications receiving 346 citations. Previous affiliations of Jerome I. Rotter include Los Angeles Biomedical Research Institute & University of California, Los Angeles.
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Journal ArticleDOI
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies
Andrew P. Morris,Andrew P. Morris,Thu H Le,Haojia Wu,Artur Akbarov,Peter J. van der Most,Gibran Hemani,George Davey Smith,Anubha Mahajan,Kyle J. Gaulton,Girish N. Nadkarni,Adan Valladares-Salgado,Niels Wacher-Rodarte,Josyf C. Mychaleckyj,Nicole Dueker,Xiuqing Guo,Yang Hai,Jeff Haessler,Yoichiro Kamatani,Adrienne M. Stilp,Gu Zhu,James P. Cook,Johan Ärnlöv,Johan Ärnlöv,Susan H. Blanton,Martin H. de Borst,Erwin P. Bottinger,Thomas A. Buchanan,Sylvia Cechova,Fadi J. Charchar,Fadi J. Charchar,Fadi J. Charchar,Pei-Lun Chu,Jeffrey Damman,James Eales,Ali G. Gharavi,Vilmantas Giedraitis,Andrew C. Heath,Eli Ipp,Eli Ipp,Krzysztof Kiryluk,Holly Kramer,Michiaki Kubo,Anders Larsson,Cecilia M. Lindgren,Cecilia M. Lindgren,Yingchang Lu,Pamela A. F. Madden,Grant W. Montgomery,George Papanicolaou,Leslie J. Raffel,Ralph L. Sacco,Ralph L. Sacco,Elena Sanchez,Holger Stark,Johan Sundström,Kent D. Taylor,Anny H. Xiang,Aleksandra Zivkovic,Lars Lind,Erik Ingelsson,Erik Ingelsson,Nicholas G. Martin,John Whitfield,Jianwen Cai,Cathy C. Laurie,Yukinori Okada,Koichi Matsuda,Charles Kooperberg,Yii-Der Ida Chen,Tatjana Rundek,Stephen S. Rich,Ruth J. F. Loos,Esteban J. Parra,Miguel Cruz,Jerome I. Rotter,Harold Snieder,Maciej Tomaszewski,Benjamin D. Humphreys,Nora Franceschini +79 more
TL;DR: Trans-ethnic genome-wide meta-analyses for eGFR in 312,468 individuals are performed and novel loci and downstream putative causal genes are identified, offering insight into clinical outcomes and routes to CKD treatment development.
Journal ArticleDOI
Overlap of Genetic Risk between Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis
Brian D. Hobbs,Rachel K. Putman,Tetsuro Araki,Mizuki Nishino,Gunnar Gudmundsson,Vilmundur Gudnason,Gudny Eiriksdottir,Nuno Rodrigues Zilhao Nogueira,Josée Dupuis,Josée Dupuis,Hanfei Xu,George T. O'Connor,George T. O'Connor,Ani Manichaikul,Jennifer N. Nguyen,Anna J. Podolanczuk,Purnema Madahar,Jerome I. Rotter,Jerome I. Rotter,David J. Lederer,R. Graham Barr,Stephen S. Rich,Elizabeth J. Ampleford,Victor E. Ortega,Stephen P. Peters,Wanda K. O'Neal,John D. Newell,John D. Newell,Eugene R. Bleecker,Deborah A. Meyers,Richard J. Allen,Justin M. Oldham,Shwu Fan Ma,Imre Noth,R. Gisli Jenkins,Toby M. Maher,Toby M. Maher,Richard Hubbard,Richard Hubbard,Louise V. Wain,Tasha E. Fingerlin,David A. Schwartz,George R. Washko,Ivan O. Rosas,Edwin K. Silverman,Hiroto Hatabu,Michael H. Cho,Gary M. Hunninghake +47 more
TL;DR: In a genome-wide association study of ILA in six studies, strong evidence for an effect of previously described IPF loci is found and distinct genetically-driven biologic pathways between ILA and IPF are suggested.
Journal ArticleDOI
Evaluation of mitochondrial DNA copy number estimation techniques.
Ryan J. Longchamps,Christina A. Castellani,Stephanie Y. Yang,Charles E. Newcomb,Jason A Sumpter,John A. Lane,Megan L. Grove,Eliseo Guallar,Nathan Pankratz,Kent D. Taylor,Jerome I. Rotter,Eric Boerwinkle,Eric Boerwinkle,Dan E. Arking +13 more
TL;DR: The field moves towards more accurate methods for mtDNA-CN, as well as re-analyze trait associations as more WGS data becomes available from larger initiatives such as TOPMed.
Journal ArticleDOI
Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease.
Johanna Jakobsdottir,Sven J. van der Lee,Joshua C. Bis,Vincent Chouraki,David Li-Kroeger,Shinya Yamamoto,Megan L. Grove,Adam C. Naj,Maria Vronskaya,Jose L. Salazar,Anita L. DeStefano,Jennifer A. Brody,Albert V. Smith,Najaf Amin,Rebecca Sims,Carla A. Ibrahim-Verbaas,Seung Hoan Choi,Claudia L. Satizabal,Oscar L. Lopez,Alexa S. Beiser,M. Arfan Ikram,Melissa E. Garcia,Caroline Hayward,Tibor V. Varga,Samuli Ripatti,Paul W. Franks,Göran Hallmans,Olov Rolandsson,Jan Håkon Jansson,David J. Porteous,Veikko Salomaa,Gudny Eiriksdottir,Kenneth Rice,Hugo J. Bellen,Daniel Levy,André G. Uitterlinden,Valur Emilsson,Jerome I. Rotter,Thor Aspelund,Christopher J. O'Donnell,Annette L. Fitzpatrick,Lenore J. Launer,Albert Hofman,Li-San Wang,Julie Williams,Gerard D. Schellenberg,Eric Boerwinkle,Bruce M. Psaty,Sudha Seshadri,Joshua M. Shulman,Vilmundur Gudnason,Cornelia M. van Duijn +51 more
TL;DR: The authors performed an exome-wide association analysis in 1393 late-onset Alzheimer's disease (LOAD) cases and 8141 controls from the CHARGE consortium and found that a rare variant (P155L) in TM2D3 was enriched in Icelanders (~0.5% versus <0.05% in other European populations).
Journal ArticleDOI
Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose
Peitao Wu,Denis Rybin,Lawrence F. Bielak,Mary F. Feitosa,Nora Franceschini,Yize Li,Yingchang Lu,Jonathan Marten,Solomon K. Musani,Raymond Noordam,Sridharan Raghavan,Sridharan Raghavan,Sridharan Raghavan,Lynda M. Rose,Karen Schwander,Albert V. Smith,Salman M. Tajuddin,Dina Vojinovic,Najaf Amin,Donna K. Arnett,Erwin P. Bottinger,Ayse Demirkan,Jose C. Florez,Jose C. Florez,Mohsen Ghanbari,Mohsen Ghanbari,Tamara B. Harris,Lenore J. Launer,Jingmin Liu,Jun Liu,Dennis O. Mook-Kanamori,Alison D. Murray,Mike A. Nalls,Patricia A. Peyser,André G. Uitterlinden,Trudy Voortman,Claude Bouchard,Daniel I. Chasman,Daniel I. Chasman,Adolfo Correa,Renée de Mutsert,Michele K. Evans,Vilmundur Gudnason,Caroline Hayward,Linda Kao,Sharon L.R. Kardia,Charles Kooperberg,Ruth J. F. Loos,Michael M. Province,Tuomo Rankinen,Susan Redline,Susan Redline,Susan Redline,Paul M. Ridker,Paul M. Ridker,Jerome I. Rotter,David S. Siscovick,Blair H. Smith,Cornelia M. van Duijn,Alan B. Zonderman,D. C. Rao,James G. Wilson,Josée Dupuis,Josée Dupuis,James B. Meigs,James B. Meigs,Ching-Ti Liu,Jason L. Vassy,Jason L. Vassy +68 more
TL;DR: The identification of loci exhibiting potential interaction with baseline smoking status provides evidence for genetic interactions with smoking exposure that may explain some of the heterogeneity in the association between smoking and T2D.