Miguel Cruz

TL;DR: In this paper, the authors aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry.

TL;DR: This cooperative mechanism favors the assembly of homogeneous “immunoproteasomes” containing all three inducible subunits, suggesting that these subunits act in concert to enhance proteasomal generation of major histocompatibility complex class I–binding peptides.

TL;DR: A panel of 446 ancestry informative markers (AIMs) optimized to estimate ancestral proportions in individuals and populations throughout Latin America will be useful resources to explore population history of admixture in Latin America and to correct for the potential effects of population stratification in admixed samples in the region.

TL;DR: This work characterized the admixture proportions in a sample of 286 unrelated T2D patients and 275 controls from Mexico City and discussed the implications of the results for admixture mapping studies.

TL;DR: An important role for c-myc oncogene is suggested in the development of tumors of the uterine cervix and up to 60-fold amplification of c- myc is detected.