P
Philippe Robert
Researcher at University of Oslo
Publications - 108
Citations - 1804
Philippe Robert is an academic researcher from University of Oslo. The author has contributed to research in topics: Biology & Computer science. The author has an hindex of 16, co-authored 95 publications receiving 1135 citations. Previous affiliations of Philippe Robert include Oslo University Hospital & Centre national de la recherche scientifique.
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Journal ArticleDOI
Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
Dorota Klysz,Xuguang Tai,Philippe Robert,Marco Craveiro,Gaspard Cretenet,Leal Oburoglu,Cédric Mongellaz,Stefan Floess,Vanessa Fritz,Maria I. Matias,Carmen S M Yong,Carmen S M Yong,Natalie Surh,Julien C. Marie,Julien C. Marie,Jochen Huehn,Valérie S. Zimmermann,Sandrina Kinet,Valerie Dardalhon,Naomi Taylor +19 more
TL;DR: It is shown that exogenous nutrient availability regulated the differentiation of naïve CD4+ T cells into distinct subsets, and α-ketoglutarate (αKG), the glutamine-derived metabolite that enters into the mitochondrial citric acid cycle, acted as a metabolic regulator of CD4- T cell differentiation.
Journal ArticleDOI
Class-switch recombination occurs infrequently in germinal centers
Jonathan A. Roco,Luka Mesin,Sebastian Binder,Christian M. Nefzger,Paula Gonzalez-Figueroa,Pablo F. Canete,Julia I. Ellyard,Qian Shen,Philippe Robert,Jean Cappello,Harpreet Vohra,Yang Zhang,Carla R. Nowosad,Ariën Schiepers,Lynn M. Corcoran,Lynn M. Corcoran,Kai-Michael Toellner,Jose M. Polo,Michael Meyer-Hermann,Gabriel D. Victora,Carola G. Vinuesa,Carola G. Vinuesa +21 more
TL;DR: It is shown that CSR is triggered prior to differentiation into GC B cells or plasmablasts and is greatly diminished in GCs, and the existence of IgM-dominated GCs is demonstrated, which are unlikely to occur under the assumption of ongoing switching.
Journal ArticleDOI
A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding.
Rahmad Akbar,Philippe Robert,Milena Pavlović,Jeliazko R. Jeliazkov,Igor Snapkov,Andrei Slabodkin,Cédric R. Weber,Lonneke Scheffer,Enkelejda Miho,Ingrid Hobæk Haff,Dag Haug,Fridtjof Lund-Johansen,Yana Safonova,Geir Kjetil Sandve,Victor Greiff +14 more
TL;DR: In this paper, the authors identify structural interaction motifs, which together compose a commonly shared structure-based vocabulary of paratope-epitope interactions, and show that this vocabulary enables the machine learnability of antibody-antigen binding using generative machine learning.
Journal ArticleDOI
A Novel Leukocyte Adhesion Deficiency III Variant: Kindlin-3 Deficiency Results in Integrin and Nonintegrin-Related Defects in Different Steps of Leukocyte Adhesion
Philippe Robert,Matthias Canault,Catherine Farnarier,Alan T. Nurden,Charlotte Grosdidier,Vincent Barlogis,Pierre Bongrand,Anne Pierres,Anne Pierres,Hervé Chambost,Marie-Christine Alessi +10 more
TL;DR: The results suggest looking for a possible kindlin-3 involvement in membrane dynamical event independent of integrin-mediated adhesion in a patient with a new mutation of FERMT3 and lack of kindlins-3 expression in platelets and leukocytes.
Journal ArticleDOI
Force Measurements of TCR/pMHC Recognition at T Cell Surface
Pierre-Henri Puech,Damien Nevoltris,Philippe Robert,Laurent Limozin,C Boyer,C Boyer,Pierre Bongrand +6 more
TL;DR: The rupture forces and adhesion frequencies of single recognition complexes between an affinity selected peptide/MHC complex and a TCR at a murine hybridoma surface were measured using Atomic Force Microscopy to help the dissection of the sequential steps by which the TCR reads the peptide or MHC complex in order to control T cell activation.