R
Regina Manansala
Researcher at University of Wisconsin–Milwaukee
Publications - 9
Citations - 692
Regina Manansala is an academic researcher from University of Wisconsin–Milwaukee. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 3, co-authored 7 publications receiving 201 citations.
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Journal ArticleDOI
The polygenic and monogenic basis of blood traits and diseases
Dragana Vuckovic,Erik L. Bao,Parsa Akbari,Caleb A. Lareau,Abdou Mousas,Tao Jiang,Ming-Huei Chen,Laura M. Raffield,Manuel Tardaguila,Jennifer E. Huffman,Scott C. Ritchie,Karyn Megy,Hannes Ponstingl,Christopher J. Penkett,Patrick K. Albers,Emilie M. Wigdor,Saori Sakaue,Arden Moscati,Regina Manansala,Ken Sin Lo,Huijun Qian,Masato Akiyama,Traci M. Bartz,Yoav Ben-Shlomo,Andrew D Beswick,Jette Bork-Jensen,Erwin P. Bottinger,Jennifer A. Brody,Frank J. A. van Rooij,Kumaraswamy Naidu Chitrala,Peter W.F. Wilson,Hélène Choquet,John Danesh,Emanuele Di Angelantonio,Niki Dimou,Jingzhong Ding,Paul Elliott,Tõnu Esko,Michele K. Evans,Stephan B. Felix,James S. Floyd,Linda Broer,Niels Grarup,Michael H. Guo,Qi Guo,Andreas Greinacher,Jeffrey Haessler,Torben Hansen,J. M. M. Howson,Wei Huang,Eric Jorgenson,Tim Kacprowski,Mika Kähönen,Yoichiro Kamatani,Masahiro Kanai,Savita Karthikeyan,Fotios Koskeridis,Leslie A. Lange,Terho Lehtimäki,Allan Linneberg,Yongmei Liu,Leo-Pekka Lyytikäinen,Ani Manichaikul,Koichi Matsuda,Karen L. Mohlke,Nina Mononen,Yoshinori Murakami,Girish N. Nadkarni,Kjell Nikus,Nathan Pankratz,Oluf Pedersen,Michael Preuss,Bruce M. Psaty,Olli T. Raitakari,Stephen S. Rich,Benjamin Rodriguez,Jonathan D. Rosen,Jerome I. Rotter,Petra Schubert,Cassandra N. Spracklen,Praveen Surendran,Hua Tang,Jean-Claude Tardif,Mohsen Ghanbari,Uwe Völker,Henry Völzke,Nicholas A. Watkins,Stefan Weiss,VA Million Veteran Program,Na Cai,Kousik Kundu,Stephen B. Watt,Klaudia Walter,Alan B. Zonderman,Kelly Cho,Yun Li,Ruth J. F. Loos,Julian C. Knight,Michel Georges,Oliver Stegle,Evangelos Evangelou,Yukinori Okada,David J. Roberts,Michael Inouye,Andrew D. Johnson,Paul L. Auer,William J. Astle,Alexander P. Reiner,Adam S. Butterworth,Willem H. Ouwehand,Guillaume Lettre,Vijay G. Sankaran,Vijay G. Sankaran,Nicole Soranzo +113 more
TL;DR: The results show the power of large-scale blood cell trait GWAS to interrogate clinically meaningful variants across a wide allelic spectrum of human variation.
Journal ArticleDOI
Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.
Ming-Huei Chen,Laura M. Raffield,Abdou Mousas,Saori Sakaue,Jennifer E. Huffman,Arden Moscati,Bhavi Trivedi,Tao Jiang,Parsa Akbari,Dragana Vuckovic,Erik L. Bao,Xue Zhong,Regina Manansala,Véronique Laplante,Minhui Chen,Ken Sin Lo,Huijun Qian,Caleb A. Lareau,Mélissa Beaudoin,Karen A. Hunt,Masato Akiyama,Traci M. Bartz,Yoav Ben-Shlomo,Andrew D Beswick,Jette Bork-Jensen,Erwin P. Bottinger,Jennifer A. Brody,Frank J. A. van Rooij,Kumaraswamynaidu Chitrala,Kelly Cho,Hélène Choquet,Adolfo Correa,John Danesh,Emanuele Di Angelantonio,Niki Dimou,Jingzhong Ding,Paul Elliott,Tõnu Esko,Michele K. Evans,James S. Floyd,Linda Broer,Niels Grarup,Michael H. Guo,Andreas Greinacher,Jeffrey Haessler,Torben Hansen,Joanna M. M. Howson,Qin Qin Huang,Wei Huang,Eric Jorgenson,Tim Kacprowski,Mika Kähönen,Yoichiro Kamatani,Masahiro Kanai,Savita Karthikeyan,Fotis Koskeridis,Leslie A. Lange,Terho Lehtimäki,Markus M. Lerch,Allan Linneberg,Yongmei Liu,Leo-Pekka Lyytikäinen,Ani Manichaikul,Hilary C. Martin,Koichi Matsuda,Karen L. Mohlke,Nina Mononen,Yoshinori Murakami,Girish N. Nadkarni,Matthias Nauck,Kjell Nikus,Willem H. Ouwehand,Nathan Pankratz,Oluf Pedersen,Michael Preuss,Bruce M. Psaty,Olli T. Raitakari,David J. Roberts,Stephen S. Rich,Benjamin Rodriguez,Jonathan D. Rosen,Jerome I. Rotter,Petra Schubert,Cassandra N. Spracklen,Praveen Surendran,Hua Tang,Jean-Claude Tardif,Richard C. Trembath,Mohsen Ghanbari,Uwe Völker,Henry Völzke,Nicholas A. Watkins,Alan B. Zonderman,VA Million Veteran Program,Peter W.F. Wilson,Yun Li,Adam S. Butterworth,Jean-François Gauchat,Charleston W. K. Chiang,Bingshan Li,Ruth J. F. Loos,William J. Astle,Evangelos Evangelou,David A. van Heel,Vijay G. Sankaran,Yukinori Okada,Nicole Soranzo,Andrew D. Johnson,Alexander P. Reiner,Paul L. Auer,Guillaume Lettre,Guillaume Lettre +111 more
TL;DR: The clinical significance and predictive value of trans-ethnic variants in multiple populations are explored, genetic architecture and the effect of natural selection on these blood phenotypes between populations are compared and the value of a more global representation of populations in genetic studies is highlighted.
Posted ContentDOI
The Polygenic and Monogenic Basis of Blood Traits and Diseases
Dragana Vuckovic,Dragana Vuckovic,Erik L. Bao,Erik L. Bao,Parsa Akbari,Caleb A. Lareau,Caleb A. Lareau,Abdou Mousas,Tao Jiang,Tao Jiang,Ming-Huei Chen,Laura M. Raffield,Manuel Tardaguila,Jennifer E. Huffman,Scott C. Ritchie,Karyn Megy,Karyn Megy,Karyn Megy,Hannes Ponstingl,Christopher J. Penkett,Christopher J. Penkett,Patrick K. Albers,Emilie M. Wigdor,Saori Sakaue,Arden Moscati,Regina Manansala,Ken Sin Lo,Huijun Qian,Masato Akiyama,Traci M. Bartz,Yoav Ben-Shlomo,Andrew D Beswick,Jette Bork-Jensen,Erwin P. Bottinger,Erwin P. Bottinger,Jennifer A. Brody,Frank J. A. van Rooij,Kumaraswamy Naidu Chitrala,Kelly Cho,Kelly Cho,Kelly Cho,Hélène Choquet,Adolfo Correa,John Danesh,Emanuele Di Angelantonio,Niki Dimou,Niki Dimou,Jingzhong Ding,Paul Elliott,Tõnu Esko,Michele K. Evans,Stephan B. Felix,James S. Floyd,Linda Broer,Niels Grarup,Michael H. Guo,Michael H. Guo,Andreas Greinacher,Jeffrey Haessler,Torben Hansen,Joanna M. M. Howson,Joanna M. M. Howson,Wei Huang,Eric Jorgenson,Tim Kacprowski,Tim Kacprowski,Mika Kähönen,Yoichiro Kamatani,Masahiro Kanai,Savita Karthikeyan,Fotis Koskeridis,Leslie A. Lange,Terho Lehtimäki,Allan Linneberg,Allan Linneberg,Yongmei Liu,Leo-Pekka Lyytikäinen,Ani Manichaikul,Koichi Matsuda,Karen L. Mohlke,Nina Mononen,Yoshinori Murakami,Girish N. Nadkarni,Kjell Nikus,Nathan Pankratz,Oluf Pedersen,Michael Preuss,Bruce M. Psaty,Olli T. Raitakari,Olli T. Raitakari,Stephen S. Rich,Benjamin Rodriguez,Jonathan D. Rosen,Jerome I. Rotter,Petra Schubert,Cassandra N. Spracklen,Praveen Surendran,Hua Tang,Jean-Claude Tardif,Jean-Claude Tardif,Mohsen Ghanbari,Uwe Völker,Henry Völzke,Nicholas A. Watkins,Stefan Weiss,VA Million Veteran Program,Na Cai,Kousik Kundu,Stephen B. Watt,Klaudia Walter,Alan B. Zonderman,Peter W.F. Wilson,Yun Li,Ruth J. F. Loos,Julian C. Knight,Michel Georges,Oliver Stegle,Evangelos Evangelou,Evangelos Evangelou,Yukinori Okada,David J. Roberts,David J. Roberts,Michael Inouye,Andrew D. Johnson,Paul L. Auer,William J. Astle,William J. Astle,Alexander P. Reiner,Adam S. Butterworth,Willem H. Ouwehand,Guillaume Lettre,Guillaume Lettre,Vijay G. Sankaran,Vijay G. Sankaran,Nicole Soranzo,Nicole Soranzo +135 more
TL;DR: These results show the power of large-scale blood cell GWAS to interrogate clinically meaningful variants across the full allelic spectrum of human variation.
Journal ArticleDOI
Whole-Genome Sequencing Association Analyses of Stroke and Its Subtypes in Ancestrally Diverse Populations From Trans-Omics for Precision Medicine Project.
Yao Hu,Jeffrey Haessler,Regina Manansala,Kerri L. Wiggins,Arden Moscati,Alexa S. Beiser,Nancy L. Heard-Costa,Chloé Sarnowski,Laura M. Raffield,Jaeyoon Chung,Jaeyoon Chung,Sandro Marini,Sandro Marini,Christopher D. Anderson,Christopher D. Anderson,Jonathan Rosand,Jonathan Rosand,Huichun Xu,Xiao Sun,Tanika N. Kelly,Quenna Wong,Leslie A. Lange,Jerome I. Rotter,Adolfo Correa,Ramachandran S. Vasan,Sudha Seshadri,Sudha Seshadri,Stephen S. Rich,Ron Do,Ruth J. F. Loos,William T. Longstreth,Joshua C. Bis,Bruce M. Psaty,Bruce M. Psaty,David L. Tirschwell,Themistocles L. Assimes,Brian Silver,Simin Liu,Rebecca D. Jackson,Sylvia Wassertheil-Smoller,Braxton D. Mitchell,Braxton D. Mitchell,Myriam Fornage,Paul L. Auer,Alexander P. Reiner,Alexander P. Reiner,Charles Kooperberg +46 more
TL;DR: In this paper, the authors identified 51 loci associated with stroke (mostly ischemic) in a genome-wide association study and found that most of the loci were located in the brain.
Journal ArticleDOI
A unified linear mixed model for familial relatedness and population structure in genetic association studies.
TL;DR: A unified linear mixed model is developed, which can account for both the additive and dominance effects of FR and PS correlations as well as their possible random interactions.