S
Stephen B. Watt
Researcher at Wellcome Trust Sanger Institute
Publications - 4
Citations - 457
Stephen B. Watt is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Genome-wide association study & Allele. The author has an hindex of 4, co-authored 4 publications receiving 119 citations.
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Journal ArticleDOI
The polygenic and monogenic basis of blood traits and diseases
Dragana Vuckovic,Erik L. Bao,Parsa Akbari,Caleb A. Lareau,Abdou Mousas,Tao Jiang,Ming-Huei Chen,Laura M. Raffield,Manuel Tardaguila,Jennifer E. Huffman,Scott C. Ritchie,Karyn Megy,Hannes Ponstingl,Christopher J. Penkett,Patrick K. Albers,Emilie M. Wigdor,Saori Sakaue,Arden Moscati,Regina Manansala,Ken Sin Lo,Huijun Qian,Masato Akiyama,Traci M. Bartz,Yoav Ben-Shlomo,Andrew D Beswick,Jette Bork-Jensen,Erwin P. Bottinger,Jennifer A. Brody,Frank J. A. van Rooij,Kumaraswamy Naidu Chitrala,Peter W.F. Wilson,Hélène Choquet,John Danesh,Emanuele Di Angelantonio,Niki Dimou,Jingzhong Ding,Paul Elliott,Tõnu Esko,Michele K. Evans,Stephan B. Felix,James S. Floyd,Linda Broer,Niels Grarup,Michael H. Guo,Qi Guo,Andreas Greinacher,Jeffrey Haessler,Torben Hansen,J. M. M. Howson,Wei Huang,Eric Jorgenson,Tim Kacprowski,Mika Kähönen,Yoichiro Kamatani,Masahiro Kanai,Savita Karthikeyan,Fotios Koskeridis,Leslie A. Lange,Terho Lehtimäki,Allan Linneberg,Yongmei Liu,Leo-Pekka Lyytikäinen,Ani Manichaikul,Koichi Matsuda,Karen L. Mohlke,Nina Mononen,Yoshinori Murakami,Girish N. Nadkarni,Kjell Nikus,Nathan Pankratz,Oluf Pedersen,Michael Preuss,Bruce M. Psaty,Olli T. Raitakari,Stephen S. Rich,Benjamin Rodriguez,Jonathan D. Rosen,Jerome I. Rotter,Petra Schubert,Cassandra N. Spracklen,Praveen Surendran,Hua Tang,Jean-Claude Tardif,Mohsen Ghanbari,Uwe Völker,Henry Völzke,Nicholas A. Watkins,Stefan Weiss,VA Million Veteran Program,Na Cai,Kousik Kundu,Stephen B. Watt,Klaudia Walter,Alan B. Zonderman,Kelly Cho,Yun Li,Ruth J. F. Loos,Julian C. Knight,Michel Georges,Oliver Stegle,Evangelos Evangelou,Yukinori Okada,David J. Roberts,Michael Inouye,Andrew D. Johnson,Paul L. Auer,William J. Astle,Alexander P. Reiner,Adam S. Butterworth,Willem H. Ouwehand,Guillaume Lettre,Vijay G. Sankaran,Vijay G. Sankaran,Nicole Soranzo +113 more
TL;DR: The results show the power of large-scale blood cell trait GWAS to interrogate clinically meaningful variants across a wide allelic spectrum of human variation.
Posted ContentDOI
The Polygenic and Monogenic Basis of Blood Traits and Diseases
Dragana Vuckovic,Dragana Vuckovic,Erik L. Bao,Erik L. Bao,Parsa Akbari,Caleb A. Lareau,Caleb A. Lareau,Abdou Mousas,Tao Jiang,Tao Jiang,Ming-Huei Chen,Laura M. Raffield,Manuel Tardaguila,Jennifer E. Huffman,Scott C. Ritchie,Karyn Megy,Karyn Megy,Karyn Megy,Hannes Ponstingl,Christopher J. Penkett,Christopher J. Penkett,Patrick K. Albers,Emilie M. Wigdor,Saori Sakaue,Arden Moscati,Regina Manansala,Ken Sin Lo,Huijun Qian,Masato Akiyama,Traci M. Bartz,Yoav Ben-Shlomo,Andrew D Beswick,Jette Bork-Jensen,Erwin P. Bottinger,Erwin P. Bottinger,Jennifer A. Brody,Frank J. A. van Rooij,Kumaraswamy Naidu Chitrala,Kelly Cho,Kelly Cho,Kelly Cho,Hélène Choquet,Adolfo Correa,John Danesh,Emanuele Di Angelantonio,Niki Dimou,Niki Dimou,Jingzhong Ding,Paul Elliott,Tõnu Esko,Michele K. Evans,Stephan B. Felix,James S. Floyd,Linda Broer,Niels Grarup,Michael H. Guo,Michael H. Guo,Andreas Greinacher,Jeffrey Haessler,Torben Hansen,Joanna M. M. Howson,Joanna M. M. Howson,Wei Huang,Eric Jorgenson,Tim Kacprowski,Tim Kacprowski,Mika Kähönen,Yoichiro Kamatani,Masahiro Kanai,Savita Karthikeyan,Fotis Koskeridis,Leslie A. Lange,Terho Lehtimäki,Allan Linneberg,Allan Linneberg,Yongmei Liu,Leo-Pekka Lyytikäinen,Ani Manichaikul,Koichi Matsuda,Karen L. Mohlke,Nina Mononen,Yoshinori Murakami,Girish N. Nadkarni,Kjell Nikus,Nathan Pankratz,Oluf Pedersen,Michael Preuss,Bruce M. Psaty,Olli T. Raitakari,Olli T. Raitakari,Stephen S. Rich,Benjamin Rodriguez,Jonathan D. Rosen,Jerome I. Rotter,Petra Schubert,Cassandra N. Spracklen,Praveen Surendran,Hua Tang,Jean-Claude Tardif,Jean-Claude Tardif,Mohsen Ghanbari,Uwe Völker,Henry Völzke,Nicholas A. Watkins,Stefan Weiss,VA Million Veteran Program,Na Cai,Kousik Kundu,Stephen B. Watt,Klaudia Walter,Alan B. Zonderman,Peter W.F. Wilson,Yun Li,Ruth J. F. Loos,Julian C. Knight,Michel Georges,Oliver Stegle,Evangelos Evangelou,Evangelos Evangelou,Yukinori Okada,David J. Roberts,David J. Roberts,Michael Inouye,Andrew D. Johnson,Paul L. Auer,William J. Astle,William J. Astle,Alexander P. Reiner,Adam S. Butterworth,Willem H. Ouwehand,Guillaume Lettre,Guillaume Lettre,Vijay G. Sankaran,Vijay G. Sankaran,Nicole Soranzo,Nicole Soranzo +135 more
TL;DR: These results show the power of large-scale blood cell GWAS to interrogate clinically meaningful variants across the full allelic spectrum of human variation.
Posted ContentDOI
Comparative analysis of neutrophil and monocyte epigenomes
Daniel Rico,Joost H.A. Martens,Kate Downes,Enrique Carrillo-de-Santa-Pau,Pancaldi,Alessandra Breschi,David J. Richardson,Simon Heath,Sadia Saeed,Mattia Frontini,Lu Chen,Stephen B. Watt,Franz-Josef Müller,Laura Clarke,Hinri Kerstens,Steven P. Wilder,Emilio Palumbo,Sarah Djebali,Emanuele Raineri,Angelika Merkel,Anna Esteve-Codina,Marc Sultan,van Bommel A,Gut M,Marie-Laure Yaspo,Rubio M,Fernandez Jm,Antony P. Attwood,de la Torre,Royo R,Stamatina Fragkogianni,Gelpí Jl,Torrents D,Iotchkova,Colin Logie,Ali Aghajanirefah,Abhishek Singh,Eva M. Janssen-Megens,Kim Berentsen,Erber W,Augusto Rendon,Myrto Kostadima,Remco Loos,van der Ent Ma,Anita Kaan,Nilofar Sharifi,Dirk S. Paul,Daniela C. Ifrim,Jessica Quintin,Love Mi,David G. Pisano,Frances Burden,Nicola Foad,S. Farrow,Daniel R. Zerbino,Ian Dunham,Kuijpers T,Hans Lehrach,Thomas Lengauer,Paul Bertone,Mihai G. Netea,Martin Vingron,Stephan Beck,Paul Flicek,Gut I,Willem H. Ouwehand,Christoph Bock,Nicole Soranzo,Roderic Guigó,Valencia A,Henk Stunnenberg +70 more
TL;DR: This study provides a comprehensive epigenetic chart of chromatin states in primary human neutrophils and monocytes, thus providing a valuable resource for studying the regulation of the human innate immune system.
Posted ContentDOI
Variation in PU.1 binding and chromatin looping at neutrophil enhancers influences autoimmune disease susceptibility
Stephen B. Watt,Louella Vasquez,Klaudia Walter,Alice L. Mann,Kousik Kundu,Lu Chen,Lu Chen,Lu Chen,Ying Yan,Simone Ecker,Frances Burden,S. Farrow,Ben Farr,Valentina Iotchkova,Valentina Iotchkova,Valentina Iotchkova,Heather Elding,Daniel Mead,Manuel Tardaguila,Hannes Ponstingl,David J. Richardson,Avik Datta,Paul Flicek,Laura Clarke,Kate Downes,Tomi Pastinen,Peter Fraser,Peter Fraser,Mattia Frontini,Javierre B-M.,Mikhail Spivakov,Mikhail Spivakov,Nicole Soranzo,Nicole Soranzo +33 more
TL;DR: It is shown that PU.1 binding and the associated chain of molecular changes underlie genetically-driven differences in cell count and autoimmune disease susceptibility and advance interpretation for genetic loci associated with neutrophil biology and immune disease.