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Richard Durbin
Researcher at University of Cambridge
Publications - 337
Citations - 247542
Richard Durbin is an academic researcher from University of Cambridge. The author has contributed to research in topics: Genome & Population. The author has an hindex of 125, co-authored 319 publications receiving 207192 citations. Previous affiliations of Richard Durbin include Wellcome Trust Sanger Institute & University of Manchester.
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Identifying and removing haplotypic duplication in primary genome assemblies
Dengfeng Guan,Dengfeng Guan,Shane A. McCarthy,Jonathan Wood,Kerstin Howe,Yadong Wang,Richard Durbin,Richard Durbin +7 more
TL;DR: This work presents a novel tool “purge_dups” that uses sequence similarity and read depth to automatically identify and remove both haplotigs and heterozygous overlaps and shows that it can reduce heterozygus duplication and increase assembly continuity while maintaining completeness of the primary assembly.
Journal ArticleDOI
Vertebrate gene finding from multiple-species alignments using a two-level strategy
TL;DR: DOGFISH is described, a vertebrate gene finder consisting of a cleanly separated site classifier and structure predictor that predicts transcripts and exons across the whole human genome, and identifies over 10,000 high confidence new coding exons not in the Ensembl gene set.
Journal ArticleDOI
The genome sequence of the channel bull blenny, Cottoperca gobio (Günther, 1861).
Iliana Bista,Iliana Bista,Shane A. McCarthy,Shane A. McCarthy,Jonathan Wood,Zemin Ning,H. William Detrich,Thomas Desvignes,John H. Postlethwait,William Chow,Kerstin Howe,James Torrance,Michelle Smith,Karen Oliver,Eric A. Miska,Richard Durbin,Richard Durbin +16 more
TL;DR: A genome assembly for Cottoperca gobio (channel bull blenny, (Gunther, 1861); Chordata; Actinopterygii (ray-finned fishes), a temperate water outgroup for Antarctic Notothenioids is presented in this article.
Posted ContentDOI
False gene and chromosome losses affected by assembly and sequence errors
J. H. Kim,Chul Hee Lee,Byung June Ko,DongAhn Yoo,Sohyoung Won,Adam M. Phillippy,Olivier Fedrigo,Guojie Zhang,Kerstin Howe,Jonathan Wood,Richard Durbin,Richard Durbin,Giulio Formenti,Samara Brown,Lindsey J. Cantin,Claudio V. Mello,Cho S,Arang Rhie,Heebal Kim,Erich D. Jarvis,Erich D. Jarvis +20 more
TL;DR: The Vertebrate Genomes Project (VGP) has been producing assemblies with an emphasis on being as complete and error-free as possible, utilizing long reads, long-range scaffolding data, new assembly algorithms, and manual curation as mentioned in this paper.
Posted ContentDOI
trio-sga: facilitating de novo assembly of highly heterozygous genomes with parent-child trios
TL;DR: Tripathi et al. as mentioned in this paper proposed a set of three algorithms to reduce heterozygosity in genomic data prior to assembly in organisms with moderate to high levels of homozygosity.