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Richard Durbin
Researcher at University of Cambridge
Publications - 337
Citations - 247542
Richard Durbin is an academic researcher from University of Cambridge. The author has contributed to research in topics: Genome & Population. The author has an hindex of 125, co-authored 319 publications receiving 207192 citations. Previous affiliations of Richard Durbin include Wellcome Trust Sanger Institute & University of Manchester.
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Journal ArticleDOI
The genome sequence of the brown trout, Salmo trutta Linnaeus 1758.
Tom Hansen,Per Gunnar Fjelldal,Sigbjørn Lien,Michelle Smith,Craig Corton,Karen Oliver,Jason Skelton,Emma Betteridge,Jale Doulcan,Olivier Fedrigo,Jacquelyn Mountcastle,Erich D. Jarvis,Erich D. Jarvis,Shane A. McCarthy,Shane A. McCarthy,William Chow,Kerstin Howe,James Torrance,Jonathan Wood,Ying Sims,Leanne Haggerty,Richard Challis,Jonathan Threlfall,Daniel Mead,Richard Durbin,Richard Durbin,Mark Blaxter +26 more
TL;DR: A genome assembly from an individual female Salmo trutta (the brown trout; Chordata; Actinopteri; Salmoniformes; Salmonidae) is presented and Gene annotation on Ensembl has identified 43,935 protein coding genes.
Journal ArticleDOI
A table-driven, full-sensitivity similarity search algorithm.
Gene Myers,Richard Durbin +1 more
TL;DR: This work states that in a query preprocessing step, a set of tables can be built that permit one to eliminate a large fraction of the dynamic programming matrix from consideration and to compute several steps of the remainder with a single table lookup.
Proceedings Article
An expert system for processing sequence homology data.
TL;DR: An automatic way of making most of the decisions a trained sequence analyst would make was developed by means of a rule-based expert system combined with an algorithm to avoid non-informative biased residue composition matches.
Journal ArticleDOI
Mapping epigenetic divergence in the massive radiation of Lake Malawi cichlid fishes
Grégoire Vernaz,Grégoire Vernaz,Milan Malinsky,Milan Malinsky,Hannes Svardal,Hannes Svardal,Hannes Svardal,Mingliu Du,Mingliu Du,Alexandra M. Tyers,Alexandra M. Tyers,M. Emília Santos,Richard Durbin,Richard Durbin,Martin J. Genner,George F. Turner,Eric A. Miska,Eric A. Miska +17 more
TL;DR: In this paper, the authors present a comparative genome-wide methylome and transcriptome study, focussing on liver and muscle tissues in phenotypically divergent cichlid species.
Journal ArticleDOI
Pathway-Based Factor Analysis of Gene Expression Data Produces Highly Heritable Phenotypes That Associate with Age
Andrew A. Brown,Andrew A. Brown,Zhihao Ding,Ana Viñuela,Daniel Glass,Leopold Parts,Tim D. Spector,John Winn,Richard Durbin +8 more
TL;DR: It is demonstrated that factor analysis methods combined with biological knowledge can produce more reliable phenotypes with less stochastic noise than the individual gene expression levels, which increases the power to discover biologically relevant associations.