Richard Durbin

TL;DR: This work presents a model that explicitly accounts for non-genetic factors so as to improve significantly the power of an expression Quantitative Trait Loci study, and exploits the inherent block structure of haplotype data to further enhance its sensitivity.

TL;DR: Exome sequenced 3,222 British Pakistani-heritage adults with high parental relatedness, discovering 1,111 rare-variant homozygous likely loss of function (rhLOF) genotypes predicted to disrupt (knockout) 781 genes, and showed meiotic recombination sites localised away from PRDM9-dependent hotspots, demonstratingPRDM9 redundancy in humans.

TL;DR: This study establishes a strategy for examining the genetic basis of inter-individual variability in cell behavior and identifies genes that correlate in expression with intrinsic and extrinsic PEER factors and associate outlier cell behavior with genes containing rare deleterious non-synonymous SNVs.

TL;DR: Tc7 shares with Tc1 all the sequences minimally required to parasitize upon the T c1 transposition machinery, and the genomic distribution of Tc7 shows a striking clustering on the X chromosome where two thirds of the elements are located.

TL;DR: A high-quality de novo genome assembly from a single Anopheles coluzzii mosquito is presented, which places 667 (>90%) of formerly unplaced genes into their appropriate chromosomal contexts in the AgamP4 PEST reference.