S
Satoru Miyano
Researcher at Tokyo Medical and Dental University
Publications - 874
Citations - 45801
Satoru Miyano is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Gene & Gene regulatory network. The author has an hindex of 84, co-authored 811 publications receiving 38723 citations. Previous affiliations of Satoru Miyano include University of Paderborn & Institute of Medical Science.
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Journal ArticleDOI
Identification of a p53-repressed gene module in breast cancer cells.
Takafumi Miyamoto,Chizu Tanikawa,Varalee Yodsurang,Yao-zhong Zhang,Seiya Imoto,Rui Yamaguchi,Satoru Miyano,Hidewaki Nakagawa,Koichi Matsuda +8 more
TL;DR: The p53 protein is a sophisticated transcription factor that regulates dozens of target genes simultaneously in accordance with the cellular circumstances, and it is shown that appropriate suppression of some genes belonging to the p53-repressed gene module contributed to a better prognosis of breast cancer patients.
Journal ArticleDOI
High prevalence of myeloid malignancies in progeria with Werner syndrome is associated with p53 insufficiency.
Hisaya Sato,Yoshiro Maezawa,Dai Nishijima,Eisuke Iwamoto,June Takeda,Takashi Kanamori,Masaya Yamaga,Tatsuzo Mishina,Yusuke Takeda,Shintaro Izumi,Yutaro Hino,Hiroyuki Nishi,Jun Ishiko,Y. Takeuchi,Hiyori Kaneko,Masaya Koshizaka,Naoya Mimura,Masafumi Kuzuya,Emiko Sakaida,Minoru Takemoto,Yuichi Shiraishi,Satoru Miyano,Seishi Ogawa,Atsushi Iwama,Masashi Sanada,Koutaro Yokote +25 more
TL;DR: Werner syndrome (WS) is a progeroid syndrome caused by mutations in the WRN gene which encodes the RecQ type DNA helicase for the unwinding of unusual DNA structures and is implicated in DNA replication, DNA repair, and telomere maintenance as discussed by the authors .
Journal ArticleDOI
An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature Review
Reina Takeda,Kazuaki Yokoyama,Seiichiro Kobayashi,Toyotaka Kawamata,Sousuke Nakamura,Tomofusa Fukuyama,Mika Ito,Nozomi Yusa,Eigo Shimizu,Nobuhiro Ohno,Rui Yamaguchi,Seiya Imoto,Satoru Miyano,Kaoru Uchimaru,Arinobu Tojo +14 more
TL;DR: A 62-year-old female who developed t-MN only three months after the completion of conventional chemotherapy and anti-CCR4 antibody for ATL acute type died of viral encephalomyelitis at 7 months after diagnosis.
Proceedings ArticleDOI
Partial Order-Based Bayesian Network Learning Algorithm for Estimating Gene Networks
TL;DR: This paper considers the problem of constructing the order of nodes in such algorithms based on prior knowledge of gene networks and proposes an efficient partial order-based algorithm for estimating gene networks based on Bayesian networks.