S
Satoru Miyano
Researcher at Tokyo Medical and Dental University
Publications - 874
Citations - 45801
Satoru Miyano is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Gene & Gene regulatory network. The author has an hindex of 84, co-authored 811 publications receiving 38723 citations. Previous affiliations of Satoru Miyano include University of Paderborn & Institute of Medical Science.
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Journal ArticleDOI
Massively parallel sequencing of tenosynovial giant cell tumors reveals novel CSF1 fusion transcripts and novel somatic CBL mutations
Yusuke Tsuda,Makoto Hirata,Kotoe Katayama,Toru Motoi,Daisuke Matsubara,Yoshinao Oda,Masashi Fujita,Hiroshi Kobayashi,Hirotaka Kawano,Yoshihiro Nishida,Tomohisa Sakai,Tomotake Okuma,Takahiro Goto,Koichi Ogura,Akira Kawai,Keisuke Ae,Ukei Anazawa,Yoshiyuki Suehara,Shintaro Iwata,Satoru Miyano,Seiya Imoto,Tatsuhiro Shibata,Hidewaki Nakagawa,Rui Yamaguchi,Sakae Tanaka,Koichi Matsuda +25 more
TL;DR: The frequent deletion of CSF1 exon 9 in the fusion transcripts suggested the importance of this event in the etiology of TSGCT, and the results may contribute to the development of new targeted therapies using JAK2 inhibitors for CBL‐mutated TSG CT.
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NOTCH1 pathway activating mutations and clonal evolution in pediatric T-cell acute lymphoblastic leukemia.
Shunsuke Kimura,Shunsuke Kimura,Masafumi Seki,Kenichi Yoshida,Yuichi Shiraishi,Masaharu Akiyama,Katsuyoshi Koh,Toshihiko Imamura,Atsushi Manabe,Yasuhide Hayashi,Masao Kobayashi,Akira Oka,Satoru Miyano,Seishi Ogawa,Junko Takita,Junko Takita +15 more
TL;DR: The results suggest that the presence of NOTCH1 mutations might contribute to the disease relapse of T‐ALL, with a small sample size and non–minimal residual disease–based protocol.
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Evaluation of sequence features from intrinsically disordered regions for the estimation of protein function.
Alok Sharma,Abdollah Dehzangi,James Lyons,Seiya Imoto,Satoru Miyano,Kenta Nakai,Ashwini Patil +6 more
TL;DR: This study extracted sequence features in intrinsically disordered regions and developed a scheme to use them to predict Gene Ontology Slim terms associated with proteins, and evaluated the function prediction performance of each feature.
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Twist2 functions as a tumor suppressor in murine osteosarcoma cells.
Tomoki Ishikawa,Tomoki Ishikawa,Takatsune Shimizu,Takatsune Shimizu,Arisa Ueki,Sayaka I. Yamaguchi,Nobuyuki Onishi,Eiji Sugihara,Shinji Kuninaka,Takeshi Miyamoto,Hideo Morioka,Robert Nakayama,Eisuke Kobayashi,Yoshiaki Toyama,Yo Mabuchi,Yumi Matsuzaki,Rui Yamaguchi,Satoru Miyano,Hideyuki Saya +18 more
TL;DR: Data from the present study suggest that Twist2 inhibits formation of a microenvironment conducive to tumor growth and thereby attenuates tumorigenesis in osteosarcoma.
Journal ArticleDOI
Characterization of the B-cell receptor repertoires in peanut allergic subjects undergoing oral immunotherapy.
Kazuma Kiyotani,Tu H Mai,Rui Yamaguchi,Poh Yin Yew,Mike Kulis,Kelly Orgel,Seiya Imoto,Satoru Miyano,A. Wesley Burks,Yusuke Nakamura +9 more
TL;DR: “Bcrip” is developed, a novel approach to characterize BCR repertoire by sequencing millions of BCR cDNA using next-generation sequencer and quantitative real-time PCR, which can be applied to investigate B-cell repertoires in various research areas, including food allergies as well as autoimmune and infectious diseases.