S
Satoru Miyano
Researcher at Tokyo Medical and Dental University
Publications - 874
Citations - 45801
Satoru Miyano is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Gene & Gene regulatory network. The author has an hindex of 84, co-authored 811 publications receiving 38723 citations. Previous affiliations of Satoru Miyano include University of Paderborn & Institute of Medical Science.
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A Top-r Feature Selection Algorithm for Microarray Gene Expression Data
TL;DR: The proposed algorithm first divides genes into subsets, the sizes of which are relatively small, then selects informative smaller subsets of genes from a subset and merges the chosen genes with another gene subset to update the gene subset.
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Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome
Vikas Madan,Deepika Kanojia,Jia Li,Ryoko Okamoto,Aiko Sato-Otsubo,Aiko Sato-Otsubo,Alexander Kohlmann,Masashi Sanada,Masashi Sanada,Vera Grossmann,Janani Sundaresan,Yuichi Shiraishi,Satoru Miyano,Felicitas Thol,Arnold Ganser,Henry Yang,Torsten Haferlach,Seishi Ogawa,Seishi Ogawa,H. Phillip Koeffler,H. Phillip Koeffler +20 more
TL;DR: A specific role for ZRSR2 in RNA splicing is identified and dysregulated splicing of U12-type introns is highlighted as a characteristic feature of Z RSR2 mutations in MDS.
Journal ArticleDOI
Global implementation of genomic medicine: We are not alone
Teri A. Manolio,Marc Abramowicz,Fahd Al-Mulla,Warwick P Anderson,Rudi Balling,Adam C. Berger,Steven B. Bleyl,Aravinda Chakravarti,Wasun Chantratita,Rex L. Chisholm,Vajira H. W. Dissanayake,Michael Dunn,Victor J. Dzau,Bok-Ghee Han,Tim Hubbard,Anne Kolbe,Bruce R. Korf,Michiaki Kubo,Paul Lasko,Erkki Leego,Surakameth Mahasirimongkol,Partha P. Majumdar,Gert Matthijs,Howard L. McLeod,Andres Metspalu,Pierre Meulien,Satoru Miyano,Yaakov Naparstek,P. Pearl O'Rourke,George P. Patrinos,Heidi L. Rehm,Mary V. Relling,Gad Rennert,Laura Lyman Rodriguez,Dan M. Roden,Alan R. Shuldiner,Sukdeb Sinha,Patrick Tan,Mats Ulfendahl,Robyn L. Ward,Marc S. Williams,John Wong,Eric D. Green,Geoffrey S. Ginsburg +43 more
TL;DR: Efforts to coalesce human-genomics groups around concrete but compelling signature projects should accelerate the responsible implementation of genomic medicine in efforts to improve clinical care worldwide.
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An empirical Bayesian framework for somatic mutation detection from cancer genome sequencing data
Yuichi Shiraishi,Yusuke Sato,Kenichi Chiba,Yusuke Okuno,Yasunobu Nagata,Kenichi Yoshida,Norio Shiba,Yasuhide Hayashi,Haruki Kume,Yukio Homma,Masashi Sanada,Seishi Ogawa,Satoru Miyano +12 more
TL;DR: Empirical Bayesian mutation Calling enables accurate calling of mutations with low allele frequencies harboured within a minor tumour subpopulation, thus allowing for the deciphering of fine substructures within a tumour specimen.
Journal ArticleDOI
ACTN1 Mutations Cause Congenital Macrothrombocytopenia
Shinji Kunishima,Yusuke Okuno,Yusuke Okuno,Kenichi Yoshida,Yuichi Shiraishi,Masashi Sanada,Hideki Muramatsu,Kenichi Chiba,Hiroko Tanaka,Koji Miyazaki,Michio Sakai,Masatoshi Ohtake,Ryoji Kobayashi,Akihiro Iguchi,Gen Niimi,Makoto Otsu,Yoshiyuki Takahashi,Satoru Miyano,Hidehiko Saito,Seiji Kojima,Seishi Ogawa +20 more
TL;DR: In this paper, the authors performed whole-exome sequencing and targeted Sanger sequencing to identify mutations that cause CMTP, in which a dominant mode of transmission had been suspected but for which no known responsible mutations have been documented.