Satoru Miyano

TL;DR: Overexpression of LARP4B in glioma cell lines strongly inhibited proliferation by inducing mitotic arrest and apoptosis in four of six lines as well as in two patient-derivedglioma stem cell populations, and depletion in p53 and Nf1-deficient mouse primary astrocytes promoted cell proliferation and led to increased tumor size and invasiveness in xenograft and orthotopic models.

TL;DR: In this paper, the authors have observed mutual behaviors among genes p53, MDM2, p19ARF and their products on a computational model with hybrid functional Petri net (HFPN) which is constructed based on information described in the literature.

TL;DR: Clinical and prognostic significance of immune microenvironment including the T cell clonality of TILs as well as PD-L1 and CD11c mRNA expression levels in endometrial cancer tissues are identified.

TL;DR: This research presents a novel and exciting new approach to treating multiple myeloma with a single chemotherapy drug, called “lysine-like substance,” which has never been used in this manner before.

TL;DR: It is suggested that SF3B1 plays an important role in the regulation of hematopoietic stem cells, whereas SF3b1 haploinsufficiency itself is not associated with the myelodysplastic syndrome phenotype with ring sideroblasts.