S
Satoru Miyano
Researcher at Tokyo Medical and Dental University
Publications - 874
Citations - 45801
Satoru Miyano is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Gene & Gene regulatory network. The author has an hindex of 84, co-authored 811 publications receiving 38723 citations. Previous affiliations of Satoru Miyano include University of Paderborn & Institute of Medical Science.
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Journal ArticleDOI
Whole-exome sequencing reveals the spectrum of gene mutations and the clonal evolution patterns in paediatric acute myeloid leukaemia.
Norio Shiba,Kenichi Yoshida,Yuichi Shiraishi,Yusuke Okuno,Genki Yamato,Yusuke Hara,Yasunobu Nagata,Kenichi Chiba,Hiroko Tanaka,Kiminori Terui,Motohiro Kato,Myoung-ja Park,Kentaro Ohki,Akira Shimada,Junko Takita,Daisuke Tomizawa,Kazuko Kudo,Hirokazu Arakawa,Souichi Adachi,Takashi Taga,Akio Tawa,Etsuro Ito,Keizo Horibe,Masashi Sanada,Satoru Miyano,Seishi Ogawa,Yasuhide Hayashi +26 more
TL;DR: WES of 22 paediatric AML patients revealed mutations in components of the cohesin complex, BCORL1 and ASXL2 in addition to previously known gene mutations, and revealed intratumoural heterogeneities in many patients, implicating multiple clonal evolution events in the development of AML.
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Gene expression and risk of leukemic transformation in myelodysplasia.
Yusuke Shiozawa,Yusuke Shiozawa,Luca Malcovati,Anna Gallì,Andrea Pellagatti,Mohsen Karimi,Aiko Sato-Otsubo,Yusuke Sato,Yusuke Sato,Hiromichi Suzuki,Tetsuichi Yoshizato,Kenichi Yoshida,Yuichi Shiraishi,Kenichi Chiba,Hideki Makishima,Jacqueline Boultwood,Eva Hellström-Lindberg,Satoru Miyano,Mario Cazzola,Seishi Ogawa +19 more
TL;DR: The addition of the gene expression-based classification of myelodysplasia to the clinical model improved prediction of patient outcomes and indicated biological and clinical relevance of the classification, which will improve risk prediction and treatment stratification of MDS.
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The AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC
Yusuke Takahashi,Yusuke Takahashi,Paul Sheridan,Atsushi Niida,Genta Sawada,Genta Sawada,R Uchi,Hideaki Mizuno,Junji Kurashige,K. Sugimachi,Shun Sasaki,Yukako Shimada,Kazuo Hase,Masato Kusunoki,Shin-ei Kudo,Mamoru Watanabe,Kouzo Yamada,Kenichi Sugihara,H. Yamamoto,Akira Suzuki,Y. Doki,Satoru Miyano,Masaki Mori,Koshi Mimori +23 more
TL;DR: Inhibiting the AURKA/TPX2 axis would be a novel synthetic lethal therapeutic approach for MYC-driven cancers.
Journal Article
Parallel Algorithm for Learning Optimal Bayesian Network Structure
TL;DR: This work presents a parallel algorithm for the score-based optimal structure search of Bayesian networks that can run in parallel using up to 256 processors with a parallelization efficiency of 0.74, compared to the original DP algorithm with a single processor.
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Frequent germline mutations of HAVCR2 in sporadic subcutaneous panniculitis-like T-cell lymphoma
Chantana Polprasert,Yasuhide Takeuchi,Nobuyuki Kakiuchi,Kenichi Yoshida,Thamathorn Assanasen,Wimonmas Sitthi,Udomsak Bunworasate,Arunrat Pirunsarn,Kitsada Wudhikarn,Panisinee Lawasut,Noppacharn Uaprasert,Sunisa Kongkiatkamon,Chatphatai Moonla,Masashi Sanada,Nobuhiro Akita,June Takeda,Yoichi Fujii,Hiromichi Suzuki,Yasuhito Nannya,Yuichi Shiraishi,Kenichi Chiba,Hiroko Tanaka,Satoru Miyano,Ponlapat Rojnuckarin,Seishi Ogawa,Hideki Makishima +25 more
TL;DR: Individuals harboring biallelic HAVCR2 (TIM3) germline mutations were highly susceptible to sporadic SPTCL, which was also associated with clonal somatic mutations.