S
Satoru Miyano
Researcher at Tokyo Medical and Dental University
Publications - 874
Citations - 45801
Satoru Miyano is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Gene & Gene regulatory network. The author has an hindex of 84, co-authored 811 publications receiving 38723 citations. Previous affiliations of Satoru Miyano include University of Paderborn & Institute of Medical Science.
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Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells.
Kana Tominaga,Kana Tominaga,Teppei Shimamura,Natsuko Kimura,Takahiko Murayama,Takahiko Murayama,Daisuke Matsubara,Hajime Kanauchi,Atsushi Niida,S. Shimizu,Kotoe Nishioka,Eiichi Tsuji,Masao Yano,Sumio Sugano,Yohei Shimono,Hideshi Ishii,Hideyuki Saya,Masaki Mori,Koichi Akashi,Keiichiro Tada,Toshihisa Ogawa,Arinobu Tojo,Satoru Miyano,Noriko Gotoh,Noriko Gotoh +24 more
TL;DR: Insulin-like growth factor 2 (IGF2) is a key target of NF-κB activated by HER2/HER3 signaling to form tumor spheres in breast cancer cells, and treatment with anti-IGF1/2 antibodies blocked tumorigenesis derived from the IGF1Rhigh CSC-enriched population in a patient-derived xenograft model.
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A comprehensive characterization of cis-acting splicing-associated variants in human cancer.
Yuichi Shiraishi,Keisuke Kataoka,Kenichi Chiba,Ai Okada,Yasunori Kogure,Hiroko Tanaka,Seishi Ogawa,Satoru Miyano +7 more
TL;DR: A statistical framework is developed to systematically identify SAVs disrupting or newly creating splice site motifs and applied it to matched whole-exome and transcriptome sequencing data from 8976 samples across 31 cancer types, generating a catalog of 14,438 S AVs.
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Simulation-based model checking approach to cell fate specification during Caenorhabditis elegans vulval development by hybrid functional Petri net with extension
TL;DR: The quantitative simulation-based model checking approach is a useful means to provide valuable biological insights and better understandings of biological systems and observation data that may be hard to capture with the qualitative one.
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Bio-calculus: Its Concept and Molecular Interaction.
TL;DR: This paper designs the bio-calculus, a syntax which is similar to conventional expressions in biology and at the same time specifies information needed for simulation analysis, and shows the practicality of bio-Calculus by describing and simulating some molecular interactions with bio- Calculus.
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Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis.
Ryunosuke Saiki,Yukihide Momozawa,Yasuhito Nannya,Masahiro Nakagawa,Yotaro Ochi,Tetsuichi Yoshizato,Chikashi Terao,Yutaka Kuroda,Yuichi Shiraishi,Kenichi Chiba,Hiroko Tanaka,Atsushi Niida,Seiya Imoto,Koichi Matsuda,Takayuki Morisaki,Yoshinori Murakami,Yoichiro Kamatani,Shuichi Matsuda,Michiaki Kubo,Satoru Miyano,Hideki Makishima,Seishi Ogawa,Seishi Ogawa +22 more
TL;DR: In this article, a combination of targeted sequencing of 23 clonal hematopoiesis (CH)-related genes and array-based CNA detection of blood-derived DNA was used to delineate the landscape of CH-related SNVs/indels and CNAs in 11,234 individuals without malignancies and 672 individuals with subsequent malignancy.