S
Satoru Miyano
Researcher at Tokyo Medical and Dental University
Publications - 874
Citations - 45801
Satoru Miyano is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Gene & Gene regulatory network. The author has an hindex of 84, co-authored 811 publications receiving 38723 citations. Previous affiliations of Satoru Miyano include University of Paderborn & Institute of Medical Science.
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Journal ArticleDOI
Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
T Haferlach,Yasunobu Nagata,Vera Grossmann,Yusuke Okuno,Ulrike Bacher,Genta Nagae,Susanne Schnittger,Masashi Sanada,Ayana Kon,Tamara Alpermann,Kenichi Yoshida,Andreas Roller,Niroshan Nadarajah,Yuichi Shiraishi,Yusuke Shiozawa,Kenichi Chiba,Hirokazu Tanaka,H P Koeffler,Hans-Ulrich Klein,Martin Dugas,Hiroyuki Aburatani,Alexander Kohlmann,Satoru Miyano,Claudia Haferlach,Wolfgang Kern,Seishi Ogawa +25 more
TL;DR: Large-scale genetic and molecular profiling of multiple target genes is invaluable for subclassification and prognostication in MDS patients.
Journal ArticleDOI
Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers
Ryunosuke Kogo,Teppei Shimamura,Koshi Mimori,Kohichi Kawahara,Seiya Imoto,Tomoya Sudo,Fumiaki Tanaka,Kohei Shibata,Akira Suzuki,Shizuo Komune,Satoru Miyano,Masaki Mori +11 more
TL;DR: The findings suggest that HOTAIR expression is associated with a genome-wide reprogramming of PRC2 function not only in breast cancer but also in CRC, where upregulation of this long ncRNA may be a critical element in metastatic progression.
Journal ArticleDOI
Integrated molecular analysis of clear-cell renal cell carcinoma.
Yusuke Sato,Tetsuichi Yoshizato,Yuichi Shiraishi,Shigekatsu Maekawa,Yusuke Okuno,Takumi Kamura,Teppei Shimamura,Aiko Sato-Otsubo,Genta Nagae,Hiromichi Suzuki,Yasunobu Nagata,Kenichi Yoshida,Ayana Kon,Yutaka Suzuki,Kenichi Chiba,Hiroko Tanaka,Atsushi Niida,Akihiro Fujimoto,Tatsuhiko Tsunoda,Teppei Morikawa,Daichi Maeda,Haruki Kume,Sumio Sugano,Masashi Fukayama,Hiroyuki Aburatani,Masashi Sanada,Masashi Sanada,Satoru Miyano,Yukio Homma,Seishi Ogawa,Seishi Ogawa +30 more
TL;DR: This integrated molecular analysis of clear-cell renal cell carcinoma unmasked new correlations between DNA methylation, gene mutation and/or gene expression and copy number profiles, enabling the stratification of clinical risks for patients with ccRCC.
Journal ArticleDOI
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
Akihiro Fujimoto,Yasushi Totoki,Tetsuo Abe,Keith A. Boroevich,Fumie Hosoda,Ha Hai Nguyen,Masayuki Aoki,Naoya Hosono,Michiaki Kubo,Fuyuki Miya,Yasuhito Arai,Hiroyuki Takahashi,Takuya Shirakihara,Masao Nagasaki,Tetsuo Shibuya,Kaoru Nakano,Kumiko Watanabe-Makino,Hiroko Tanaka,Hiromi Nakamura,Jun Kusuda,Hidenori Ojima,Kazuaki Shimada,Takuji Okusaka,Masaki Ueno,Yoshinobu Shigekawa,Yoshiiku Kawakami,Koji Arihiro,Hideki Ohdan,Kunihito Gotoh,Osamu Ishikawa,Shunichi Ariizumi,Masakazu Yamamoto,Terumasa Yamada,Kazuaki Chayama,Tomoo Kosuge,Hiroki Yamaue,Naoyuki Kamatani,Satoru Miyano,Hitoshi Nakagama,Yusuke Nakamura,Tatsuhiko Tsunoda,Tatsuhiro Shibata,Hidewaki Nakagawa +42 more
TL;DR: The whole-genome sequencing analysis of HCCs identified the influence of etiological background on somatic mutation patterns and subsequent carcinogenesis, as well as recurrent mutations in chromatin regulators in H CCs.
Proceedings ArticleDOI
Identification of genetic networks from a small number of gene expression patterns under the Boolean network model.
TL;DR: A much simpler algorithm is devised that is conceptually so simple that it is extensible for more realistic network models and shows that the Boolean network of size 100,000 can be identified by the algorithm from about 100 INPUT/OUTPUT pairs if the maximum indegree is bounded by 2.