S
Satoru Miyano
Researcher at Tokyo Medical and Dental University
Publications - 874
Citations - 45801
Satoru Miyano is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Gene & Gene regulatory network. The author has an hindex of 84, co-authored 811 publications receiving 38723 citations. Previous affiliations of Satoru Miyano include University of Paderborn & Institute of Medical Science.
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Journal Article
Genomic Object Net: II. Modelling biopathways by hybrid functional Petri net with extension.
TL;DR: This paper demonstrates how to create an HFPNe (hybrid functional Petri net with extension) model, using the lac operon gene regulatory mechanism and glycolytic pathway as an example to model other biopathways of interest.
Journal ArticleDOI
Functional characterization of a novel GFI1B mutation causing congenital macrothrombocytopenia.
Kunio Kitamura,Yusuke Okuno,Kenichi Yoshida,Masashi Sanada,Yuichi Shiraishi,Hideki Muramatsu,R. Kobayashi,Koichi Furukawa,Satoru Miyano,Seiji Kojima,Seishi Ogawa,Shinji Kunishima +11 more
TL;DR: Functional analysis of a novel GFI1B mutation and previous mutations was performed and Mutant‐transduced megakaryocytes produced enlarged proplatelet tips which were reduced in number.
Proceedings ArticleDOI
A state space representation of VAR models with sparse learning for dynamic gene networks
Kaname Kojima,Rui Yamaguchi,Seiya Imoto,Mai Yamauchi,Masao Nagasaki,Ryo Yoshida,Teppei Shimamura,Kazuko Ueno,Tomoyuki Higuchi,Noriko Gotoh,Satoru Miyano +10 more
TL;DR: A new calculation technique for EM algorithm that does not require the calculation of inverse matrices is introduced, which is applied to time course microarray data of lung cells treated by stimulating EGF receptors and dosing an anticancer drug, Gefitinib.
Journal ArticleDOI
Multivariate gene expression analysis reveals functional connectivity changes between normal/tumoral prostates.
André Fujita,Luciana Rodrigues Gomes,João Ricardo Sato,Rui Yamaguchi,Carlos Eduardo Thomaz,Mari Cleide Sogayar,Satoru Miyano +6 more
TL;DR: Changes in functional connectivity may be implicit in the biological process which renders some genes more informative to discriminate between normal and tumoral conditions and it was possible to capture changes in dependence networks which are related to cell transformation.
Journal ArticleDOI
De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome
Tsutomu Toki,Kenichi Yoshida,Ru Nan Wang,Sou Nakamura,Takanobu Maekawa,Kumiko Goi,Megumi C. Katoh,Seiya Mizuno,Fumihiro Sugiyama,Rika Kanezaki,Tamayo Uechi,Yukari Nakajima,Yusuke Sato,Yusuke Sato,Yusuke Okuno,Aiko Sato-Otsubo,Aiko Sato-Otsubo,Yusuke Shiozawa,Keisuke Kataoka,Yuichi Shiraishi,Masashi Sanada,Masashi Sanada,Kenichi Chiba,Hiroko Tanaka,Kiminori Terui,Tomohiko Sato,Takuya Kamio,Hirotoshi Sakaguchi,Shouichi Ohga,Madoka Kuramitsu,Isao Hamaguchi,Akira Ohara,Hitoshi Kanno,Satoru Miyano,Seiji Kojima,Akira Ishiguro,Kanji Sugita,Naoya Kenmochi,Satoru Takahashi,Koji Eto,Seishi Ogawa,Seishi Ogawa,Seishi Ogawa,Etsuro Ito +43 more
TL;DR: unique de novo TP53 germline variants found in two individuals with an IBMFS accompanied by hypogammaglobulinemia, growth retardation, and microcephaly mimicking DBA and DC are reported, providing important insights into the previously postulated connection between p53 and IBMFSs.