Satoru Miyano

TL;DR: It is demonstrated that ASXL1 is a part of a protein complex containing HCFC1 and OGT; OGT directly stabilizes AS XL1 by O-GlcNAcylation, and data suggest that MLL5, a knownHCFC1/OGT-interacting protein, is responsible for gene activation by the ASXL 1–OGT axis.

TL;DR: Hundreds of genes were affected in all tissues in each of the colonized models; however, a gene set enrichment analysis method, MetaGene Profiler, demonstrated that the specific changes of Gene Ontology (GO) categories occurred predominantly in 0WexGF LI, SPF SI, and 5Wex GF SPL, respectively.

TL;DR: Overall HBV integration sites in clinical samples were significantly enriched in regions annotated as exhibiting open chromatin, a high level of gene expression, and early replication timing in liver cells, indicating thatHBV integration in liver tissue was biased according to chromatin accessibility, with additional selection pressures in the gene promoters of tumor samples.

TL;DR: An overview of Petri net formalisms to describe biological pathways is given and the examples that analyze fundamental properties of biological pathways using T-invariant, P-invariaant, siphon, and trap are illustrated.

TL;DR: Through the simultaneous construction of gene regulatory networks and protein-protein interaction networks of Saccharomyces cerevisiae cell cycle, the role of several genes whose functions are currently unknown are predicted and the probabilistic model can detect false positives of high-throughput data, such as yeast two-hybrid data.