S
Satoru Miyano
Researcher at Tokyo Medical and Dental University
Publications - 874
Citations - 45801
Satoru Miyano is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Gene & Gene regulatory network. The author has an hindex of 84, co-authored 811 publications receiving 38723 citations. Previous affiliations of Satoru Miyano include University of Paderborn & Institute of Medical Science.
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Journal ArticleDOI
Circulating Tumor DNA Analysis for Liver Cancers and Its Usefulness as a Liquid Biopsy
Atsushi Ono,Akihiro Fujimoto,Yujiro Yamamoto,Sakura Akamatsu,Nobuhiko Hiraga,Michio Imamura,Tomokazu Kawaoka,Masataka Tsuge,Hiromi Abe,C. Nelson Hayes,Daiki Miki,Mayuko Furuta,Tatsuhiko Tsunoda,Satoru Miyano,Michiaki Kubo,Hiroshi Aikata,Hidenori Ochi,Yoshi iku Kawakami,Koji Arihiro,Hideki Ohdan,Hidewaki Nakagawa,Kazuaki Chayama +21 more
TL;DR: The usefulness of ctDNA detection and sequencing analysis of cell-free DNA for personalized treatment of liver cancer is demonstrated and can predict VP and recurrence, especially extrahepatic metastasis within 2 years.
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Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD).
Qiao-Yang Sun,Ling-Wen Ding,Kar Tong Tan,Wenwen Chien,Anand Mayakonda,De-Chen Lin,De-Chen Lin,Xin-Yi Loh,Jin-Fen Xiao,Manja Meggendorfer,Tamara Alpermann,Manoj Garg,Su Lin Lim,Vikas Madan,Norimichi Hattori,Yasunobu Nagata,Satoru Miyano,Allen Eng Juh Yeoh,Hsin-An Hou,Y. Y. Jiang,Sumiko Takao,Li Zhen Liu,Siew Zhuan Tan,Michael Lill,Mutsumi Hayashi,Akitoshi Kinoshita,Hagop M. Kantarjian,Steve Kornblau,Seishi Ogawa,T Haferlach,Henry Yang,H P Koeffler,H P Koeffler +32 more
TL;DR: Clonality analysis suggests that IDH2/1, DNMT3A, U2AF1 and TET2 mutations are clonal and occur early, and MLL-PTD likely arises after these initial mutations, whereas proliferative mutations (FLT3, RAS), typically appear later, are largely subclonal and tend to be unstable.
Journal ArticleDOI
A machine discovery from amino acid sequences by decision trees over regular patterns
Setsuo Arikawa,Satoru Miyano,Ayumi Shinohara,Satoru Kuhara,Yasuhito Mukouchi,Takeshi Shinohara +5 more
TL;DR: It is shown that the class of languages defined by decesion trees of depth at mostd overk-variable regular patterns is polynomial-time learnable in the sense of probably approximately correct (PAC) learning for any fixedd, k≥0.
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Targeting BIG3–PHB2 interaction to overcome tamoxifen resistance in breast cancer cells
Tetsuro Yoshimaru,Masato Komatsu,Taisuke Matsuo,Yi-An Chen,Yoichi Murakami,Yoichi Murakami,Kenji Mizuguchi,Eiichi Mizohata,Tsuyoshi Inoue,Miki Akiyama,Rui Yamaguchi,Seiya Imoto,Satoru Miyano,Yasuo Miyoshi,Mitsunori Sasa,Yusuke Nakamura,Yusuke Nakamura,Toyomasa Katagiri +17 more
TL;DR: A cell-permeable peptide inhibitor, called ERAP, that regulates multiple ERα-signalling pathways associated with tamoxifen resistance in breast cancer cells by inhibiting the interaction between BIG3 and PHB2 is reported.
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A versatile petri net based architecture for modeling and simulation of complex biological processes.
TL;DR: A new enhanced Petri net called hybrid functional PetriNet with extension (HFPNe) is defined, which model and simulate with HFPNe four biological processes that are diffcult to represent with the previous architecture HFPN.