S
Shaun Purcell
Researcher at Brigham and Women's Hospital
Publications - 347
Citations - 151651
Shaun Purcell is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 120, co-authored 326 publications receiving 132973 citations. Previous affiliations of Shaun Purcell include Icahn School of Medicine at Mount Sinai & University of Saint Mary.
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Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases | NOVA. The University of Newcastle's Digital Repository
Alexander Gusev,S. Hong Lee,Anna K. Kähler,Christina M. Hultman,Shaun Purcell,Steven A. McCarroll,Mark Daly,Bogdan Pasaniuc,Patrick F. Sullivan,Benjamin M. Neale,Naomi R. Wray,Soumya Raychaudhuri,Gosia Trynka,Alkes L. Price,Hilary K. Finucane,Bjarni J. Vilhjálmsson,Han Xu,Chongzhi Zang,Stephan Ripke,Brendan K. Bulik-Sullivan,E Stahl +20 more
TL;DR: These results highlight the value of analyzing components of heritability to unravel the functional architecture of common disease and find no significant contribution from rare coding variants in independent schizophrenia cohorts genotyped on GWAS and exome chips.
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Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions
Soumya Raychaudhuri,Robert M. Plenge,Robert M. Plenge,Robert M. Plenge,Elizabeth J. Rossin,Elizabeth J. Rossin,Elizabeth J. Rossin,Aylwin Ng,Shaun Purcell,Shaun Purcell,Pamela Sklar,Edward M. Scolnick,Edward M. Scolnick,Ramnik J. Xavier,David Altshuler,Mark J. Daly,Mark J. Daly +16 more
TL;DR: A statistical method that takes a list of disease regions and automatically assesses the degree of relatedness of implicated genes using 250,000 PubMed abstracts, and offers a statistically robust approach to identifying functionally related genes from across multiple disease regions—that likely represent key disease pathways.
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Genomewide association studies: history, rationale, and prospects for psychiatric disorders.
Sven Cichon,Nicholas John Craddock,Mark J. Daly,Mark J. Daly,Stephen V. Faraone,Pablo V. Gejman,John R. Kelsoe,Thomas Lehner,Douglas F. Levinson,Audra Moran,Pamela Sklar,Pamela Sklar,Patrick F. Sullivan,Richard Anney,Michael Gill,Aiden Corvin,Jan K. Buitelaar,Barbara Franke,Josephine Elia,Hakon Hakonarson,Lindsey Kent,J. J. McGough,Susan L. Smalley,Roel A. Ophoff,Eric Mick,Susan L. Santangelo,Manuel A. R. Ferreira,Shaun Purcell,Douglas M. Ruderfer,Jordan W. Smoller,Roy H. Perlis,Neale Bm,Jennifer Stone,Laura Nisenbaum,Anita Thapar,Valentina Moskvina,Peter Holmans,Michael Conlon O'Donovan,Michael John Owen,Richard D. Todd,Alexandre A. Todorov,John P. Rice,Bernie Devlin,Dan E. Arking,Aravinda Chakravarti,James B. Potash,Ann E. Pulver,Joseph D. Buxbaum,Edwin H. Cook,Leena Peltonen,Jaana Suvisaari,Joseph Piven,Danyu Lin,Patrick Sullivan,Guy A. Rouleau,Phillip Awadalla,Gerard D. Schellenberg,Stephen W. Scherer,James S. Sutcliffe,Peter Szatmari,Veronica J. Vieland,Ole A. Andreassen,Arnoldo Frigessi,Douglas Blackwood,Walter J. Muir,Michael Boehnke,Margit Burmeister,Matthew Flickinger,Weihua Guan,Jun Li,Laura J. Scott,René Breuer,Marcella Rietschel,Thomas G. Schulze,Tiffany A. Greenwood,Nicholas J. Schork,Hugh Gurling,Pierandrea Muglia,Ruchi Upmanyu,Federica Tozzi,Markus M. Noethen,Thomas F. Wienker,Michael Steffens,John I. Nurnberger,Kenneth S. Kendler,Brien P. Riley,Edwin J. C. G. van den Oord,Dorret I. Boomsma,Eco J. C. de Geus,Witte J.G. Hoogendijk,Brenda W.J.H. Penninx,A.H.M. Willemsen,Danielle Posthuma,William Coryell,S. P. Hamilton,Stafam Kloiber,Susanne Lucae,Stephan Ripke,William Lawson,Cathryn M. Lewis,P. McGuffin,Nicholas G. Martin,Naomi R. Wray,Patrick J. McGrath,Myrna M. Weissman,James Offord,William A. Scheftner,Susan L. Slager,Ayman H. Fanous,Christina M. Hultman,Sari Kivikko,Claudine Laurent,Todd Lencz,Anil K. Malhotra,Bryan J. Mowry,Elizabeth G. Holliday,Alan R. Sanders,Sibylle G. Schwab,Dieter Wildenaver,David St Clair,Frank Dudbridge,Eve H. Pickering,Jonathan Sebat,Jung-Ying Tzeng +123 more
TL;DR: GWAS methods have detected a remarkable number of robust genetic associations for dozens of common diseases and traits, leading to new pathophysiological hypotheses, although only small proportions of genetic variance have been explained thus far and therapeutic applications will require substantial further effort.
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Genomic inflation factors under polygenic inheritance.
Jian Yang,Michael N. Weedon,Shaun Purcell,Shaun Purcell,Guillaume Lettre,Karol Estrada,Cristen J. Willer,Albert V. Smith,Erik Ingelsson,Jeffrey R. O'Connell,Massimo Mangino,Reedik Mägi,Pamela A. F. Madden,Andrew C. Heath,Dale R. Nyholt,Nicholas G. Martin,Grant W. Montgomery,Timothy M. Frayling,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Mark I. McCarthy,Mark I. McCarthy,Michael E. Goddard,Peter M. Visscher +24 more
TL;DR: It is shown that in the absence of population structure and other technical artefacts, but in the presence of polygenic inheritance, substantial genomic inflation is expected, and its magnitude depends on sample size, heritability, linkage disequilibrium structure and the number of causal variants.
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Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia
Giulio Genovese,Menachem Fromer,Eli A. Stahl,Douglas M. Ruderfer,Kimberly Chambert,Mikael Landén,Jennifer L. Moran,Shaun Purcell,Pamela Sklar,Patrick F. Sullivan,Christina M. Hultman,Steven A. McCarroll,Steven A. McCarroll +12 more
TL;DR: It was found that gene-disruptive and putatively protein-damaging URVs (but not synonymous URVs) were more abundant among individuals with schizophrenia than among controls, suggesting that synaptic dysfunction may mediate a large fraction of strong, individually rare genetic influences on schizophrenia risk.