T
Thordur Sigmundsson
Researcher at University of Iceland
Publications - 56
Citations - 10942
Thordur Sigmundsson is an academic researcher from University of Iceland. The author has contributed to research in topics: Psychosis & Schizophrenia (object-oriented programming). The author has an hindex of 29, co-authored 56 publications receiving 10561 citations. Previous affiliations of Thordur Sigmundsson include King's College London & University College London.
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Journal ArticleDOI
Disruption of the neurexin 1 gene is associated with schizophrenia
Dan Rujescu,Andres Ingason,Andres Ingason,Sven Cichon,Olli Pietiläinen,Michael R. Barnes,Timothea Toulopoulou,Marco Picchioni,Evangelos Vassos,Ulrich Ettinger,Elvira Bramon,Robin M. Murray,Mirella Ruggeri,Sarah Tosato,Chiara Bonetto,Stacy Steinberg,Engilbert Sigurdsson,Thordur Sigmundsson,Hannes Petursson,Arnaldur Gylfason,Pall I. Olason,Gudmundur Hardarsson,Gudrun A. Jonsdottir,Omar Gustafsson,Ragnheidur Fossdal,Ina Giegling,Hans-Jürgen Möller,Annette M. Hartmann,Per Hoffmann,Caroline Crombie,Gillian Fraser,Nicholas Walker,Jouko Lönnqvist,Jaana Suvisaari,Annamari Tuulio-Henriksson,Srdjan Djurovic,Ingrid Melle,Ole A. Andreassen,Thomas Hansen,Thomas Werge,Lambertus A. Kiemeney,Barbara Franke,Joris A. Veltman,Jacobine E. Buizer-Voskamp,Chiara Sabatti,Roel A. Ophoff,Marcella Rietschel,Markus M. Nöthen,K. Stefansson,Leena Peltonen,David St Clair,Hreinn Stefansson,David A. Collier +52 more
TL;DR: It is concluded that NRXN1 deletions affecting exons confer risk of schizophrenia.
Journal ArticleDOI
Brain anatomy and sensorimotor gating in Asperger’s syndrome
Grainne M. McAlonan,Eileen Daly,Veena Kumari,Hugo D. Critchley,Therese van Amelsvoort,John Suckling,Andrew Simmons,Thordur Sigmundsson,Kathyrn Greenwood,Ailsa Russell,Nicole Schmitz,Francesca Happé,Patricia Howlin,Declan G. Murphy +13 more
TL;DR: It is hypothesized that Asperger's syndrome is associated with abnormalities in fronto-striatal pathways resulting in defective sensorimotor gating, and consequently characteristic difficulties inhibiting repetitive thoughts, speech and actions.
Journal ArticleDOI
Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms.
Thordur Sigmundsson,John Suckling,M. Maier,Steven Williams,Edward T. Bullmore,Kathryn Greenwood,Rimmei Fukuda,Maria A. Ron,Brian Toone +8 more
TL;DR: Anatomical abnormalities in these schizophrenic patients with marked negative symptoms were most evident in left hemispheric neocortical and limbic regions and related white matter tracts, compatible with models that depict schizophrenia as a supraregional disorder of multiple, distributed brain regions and the axonal connections between them.
Journal ArticleDOI
Genomewide Genetic Linkage Analysis Confirms the Presence of Susceptibility Loci for Schizophrenia, on Chromosomes 1q32.2, 5q33.2, and 8p21-22 and Provides Support for Linkage to Schizophrenia, on Chromosomes 11q23.3-24 and 20q12.1-11.23
Hugh Gurling,Gursharan Kalsi,Jon Brynjolfson,Thordur Sigmundsson,Robin Sherrington,Baljinder S. Mankoo,T Read,P Murphy,E Blaveri,Andrew McQuillin,Hannes Petursson,David Curtis +11 more
TL;DR: The weight of evidence for linkage to the chromosome 1q22, 5q33.2, 8p21-22 and 11q21 suggests that these regions do indeed harbor schizophrenia-susceptibility loci and is now sufficient to justify intensive investigation of these regions by methods based on linkage disequilibrium.
Journal ArticleDOI
Meta-analysis of 32 genome-wide linkage studies of schizophrenia
Mandy Y.M. Ng,Douglas F. Levinson,Stephen V. Faraone,Brian K. Suarez,Lynn E. DeLisi,Lynn E. DeLisi,Tadao Arinami,Brien P. Riley,Tiina Paunio,Tiina Paunio,A. E. Pulver,Irmansyah,Peter Holmans,Michael Escamilla,Dieter B. Wildenauer,Nigel Williams,Claudine Laurent,Bryan J. Mowry,Linda M. Brzustowicz,Michel Maziade,Pamela Sklar,D L Garver,Gonçalo R. Abecasis,Bernard Lerer,M D Fallin,Hugh Gurling,Pablo V. Gejman,Eva Lindholm,Hans W. Moises,William Byerley,Ellen M. Wijsman,Paola Forabosco,Ming T. Tsuang,Ming T. Tsuang,H-G Hwu,Yuji Okazaki,Kenneth S. Kendler,Brandon Wormley,Ayman H. Fanous,Ayman H. Fanous,Dermot Walsh,Francis A. O'Neill,Leena Peltonen,Gerald Nestadt,Virginia K. Lasseter,Kung-Yee Liang,G M Papadimitriou,Dimitris Dikeos,Sibylle G. Schwab,Michael John Owen,Michael Conlon O'Donovan,Nadine Norton,Elizabeth Hare,Henriette Raventós,Humberto Nicolini,Margot Albus,Wolfgang Maier,Vishwajit L. Nimgaonkar,Lars Terenius,J. Mallet,Melanie Jay,Stephanie Godard,Deborah A. Nertney,M. Alexander,Raymond R. Crowe,Jeremy M. Silverman,Anne S. Bassett,M-A Roy,Chantal Mérette,Carlos N. Pato,Michele T. Pato,J. Louw Roos,Yoav Kohn,Daniela Amann-Zalcenstein,Gursharan Kalsi,Andrew McQuillin,David Curtis,Jon Brynjolfson,Thordur Sigmundsson,Hannes Petursson,Alan R. Sanders,Jubao Duan,Elena Jazin,Marina Myles-Worsley,Maria Karayiorgou,Cathryn M. Lewis +85 more
TL;DR: The primary analysis met empirical criteria for ‘aggregate’ genome-wide significance, indicating that some or all of 10 bins are likely to contain loci linked to SCZ, including regions of chromosomes 1, 2q, 3q, 4q, 5q, 8p and 10q.