T
Ting Hsu Chen
Researcher at Boston University
Publications - 6
Citations - 996
Ting Hsu Chen is an academic researcher from Boston University. The author has contributed to research in topics: FEV1/FVC ratio & Spirometry. The author has an hindex of 6, co-authored 6 publications receiving 931 citations. Previous affiliations of Ting Hsu Chen include United States Department of Veterans Affairs & Veterans Health Administration.
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Journal ArticleDOI
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
Dana B. Hancock,Mark Eijgelsheim,Jemma B. Wilk,Sina A. Gharib,Laura R. Loehr,Laura R. Loehr,Kristin D. Marciante,Nora Franceschini,Yannick M.T.A. van Durme,Yannick M.T.A. van Durme,Ting Hsu Chen,Ting Hsu Chen,R. Graham Barr,Matthew B. Schabath,David Couper,Guy Brusselle,Guy Brusselle,Bruce M. Psaty,Bruce M. Psaty,Cornelia M. van Duijn,Jerome I. Rotter,André G. Uitterlinden,Albert Hofman,Naresh M. Punjabi,Fernando Rivadeneira,Alanna C. Morrison,Paul L. Enright,Kari E. North,Susan R. Heckbert,Susan R. Heckbert,Thomas Lumley,Bruno H. Stricker,George T. O'Connor,George T. O'Connor,Stephanie J. London +34 more
TL;DR: This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study, and identified eight loci associated with FEV1/FVC and one locus at or near genome-wide significance in theCHARGE Consortium dataset.
Journal ArticleDOI
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
Jemma B. Wilk,Jemma B. Wilk,Nick Shrine,Laura R. Loehr,Jing Hua Zhao,Ani Manichaikul,Lorna M. Lopez,Albert V. Smith,Susan R. Heckbert,Joanna Smolonska,Wenbo Tang,Daan W. Loth,Ivan Curjuric,Jennie Hui,Jennie Hui,Michael H. Cho,Jeanne C. Latourelle,Amanda P. Henry,Melinda C. Aldrich,Per Bakke,Terri H. Beaty,Amy R. Bentley,Ingrid B. Borecki,Guy Brusselle,Kristin M. Burkart,Ting Hsu Chen,David Couper,James D. Crapo,Gail Davies,Josée Dupuis,Josée Dupuis,Nora Franceschini,Amund Gulsvik,Dana B. Hancock,Dana B. Hancock,Tamara B. Harris,Albert Hofman,Medea Imboden,Alan James,Kay-Tee Khaw,Lies Lahousse,Lies Lahousse,Lenore J. Launer,Augusto A. Litonjua,Yongmei Liu,Kurt Lohman,David A. Lomas,Thomas Lumley,Kristin D. Marciante,Wendy L. McArdle,Bernd Meibohm,Alanna C. Morrison,Arthur W. Musk,Richard H. Myers,Kari E. North,Dirkje S. Postma,Bruce M. Psaty,Bruce M. Psaty,Stephen S. Rich,Fernando Rivadeneira,Thierry Rochat,Jerome I. Rotter,María Soler Artigas,John M. Starr,André G. Uitterlinden,Nicholas J. Wareham,Cisca Wijmenga,Pieter Zanen,Michael A. Province,Edwin K. Silverman,Ian J. Deary,Lyle J. Palmer,Lyle J. Palmer,Patricia A. Cassano,Vilmundur Gudnason,R. Graham Barr,Ruth J. F. Loos,David P. Strachan,Stephanie J. London,H. Marike Boezen,Nicole Probst-Hensch,Sina A. Gharib,Ian P. Hall,George T. O'Connor,George T. O'Connor,Martin D. Tobin,Bruno H. Stricker +86 more
TL;DR: An important role is suggested for the CHRNA5/3 region as a genetic risk factor for airflow obstruction that may be independent of smoking and implicate the HTR4 gene in the etiology of airflow obstruction.
Journal ArticleDOI
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function
Dana B. Hancock,Dana B. Hancock,María Soler Artigas,Sina A. Gharib,Amanda P. Henry,Ani Manichaikul,Adaikalavan Ramasamy,Daan W. Loth,Medea Imboden,Medea Imboden,Beate Koch,Wendy L. McArdle,Albert V. Smith,Joanna Smolonska,Akshay Sood,Wenbo Tang,Jemma B. Wilk,Jemma B. Wilk,Guangju Zhai,Guangju Zhai,Jing Hua Zhao,Hugues Aschard,Kristin M. Burkart,Ivan Curjuric,Ivan Curjuric,Mark Eijgelsheim,Paul Elliott,Xiangjun Gu,Tamara B. Harris,Christer Janson,Georg Homuth,Pirro G. Hysi,Jason Z. Liu,Laura R. Loehr,Kurt Lohman,Ruth J. F. Loos,Alisa K. Manning,Alisa K. Manning,Kristin D. Marciante,Ma'en Obeidat,Dirkje S. Postma,Melinda C. Aldrich,Guy Brusselle,Ting Hsu Chen,Ting Hsu Chen,Gudny Eiriksdottir,Nora Franceschini,Joachim Heinrich,Jerome I. Rotter,Cisca Wijmenga,O. Dale Williams,Amy R. Bentley,Albert Hofman,Cathy C. Laurie,Thomas Lumley,Alanna C. Morrison,Bonnie R. Joubert,Fernando Rivadeneira,David Couper,Stephen B. Kritchevsky,Yongmei Liu,Matthias Wjst,Louise V. Wain,Judith M. Vonk,André G. Uitterlinden,Thierry Rochat,Stephen S. Rich,Bruce M. Psaty,Bruce M. Psaty,George T. O'Connor,George T. O'Connor,Kari E. North,Daniel B. Mirel,Bernd Meibohm,Lenore J. Launer,Kay-Tee Khaw,Anna-Liisa Hartikainen,Christopher J Hammond,Sven Gläser,Jonathan Marchini,Peter Kraft,Nicholas J. Wareham,Henry Völzke,Bruno H. Stricker,Tim D. Spector,Nicole Probst-Hensch,Nicole Probst-Hensch,Deborah Jarvis,Marjo-Riitta Järvelin,Susan R. Heckbert,Susan R. Heckbert,Vilmundur Gudnason,H. Marike Boezen,R. Graham Barr,Patricia A. Cassano,David P. Strachan,Myriam Fornage,Ian P. Hall,Josée Dupuis,Josée Dupuis,Martin D. Tobin,Stephanie J. London +101 more
TL;DR: In this paper, the authors conducted genome-wide joint meta-analyses (JMA) of single nucleotide polymorphism (SNP) and SNP-by-smoking (ever-smoking or pack-years) associations on spirometic measures of pulmonary function, forced expiratory volume in one second (FEV(1)), and its ratio to forced vital capacity(FEV (1)/FVC).
Journal ArticleDOI
Genetic variants in RBFOX3 are associated with sleep latency
Najaf Amin,Karla V. Allebrandt,Ashley van der Spek,Bertram Müller-Myhsok,Karin Hek,Maris Teder-Laving,Caroline Hayward,Tõnu Esko,Josine G. van Mill,Hamdi Mbarek,Nathaniel F. Watson,Scott A. Melville,Fabiola M. Del Greco,Enda M. Byrne,Enda M. Byrne,Edwin Oole,Ivana Kolcic,Ting Hsu Chen,Daniel S. Evans,Josef Coresh,Nicole Vogelzangs,Juha Karjalainen,Gonneke Willemsen,Sina A. Gharib,Lina Zgaga,Evelin Mihailov,Katie L. Stone,Harry Campbell,Rutger W W Brouwer,Ayse Demirkan,Aaron Isaacs,Zoran Dogas,Kristin D. Marciante,Susan Campbell,Fran Borovečki,Annemarie I. Luik,Man Li,Jouke-Jan Hottenga,Jennifer E. Huffman,Mirjam C G N van den Hout,Steven R. Cummings,Yurii S. Aulchenko,Philip R. Gehrman,André G. Uitterlinden,Heinz Erich Wichmann,Heinz Erich Wichmann,Martina Müller-Nurasyid,Rudolf S N Fehrmann,Grant W. Montgomery,Albert Hofman,Albert Hofman,Wen Hong Linda Kao,Ben A. Oostra,Alan F. Wright,Jacqueline M. Vink,James F. Wilson,Peter P. Pramstaller,Andrew A. Hicks,Ozren Polasek,Naresh M. Punjabi,Susan Redline,Bruce M. Psaty,Bruce M. Psaty,Andrew C. Heath,Martha Merrow,Gregory J. Tranah,Daniel J. Gottlieb,Daniel J. Gottlieb,Dorret I. Boomsma,Nicholas G. Martin,Igor Rudan,Henning Tiemeier,Wilfred F. J. van IJcken,Brenda W.J.H. Penninx,Andres Metspalu,Thomas Meitinger,Lude Franke,Till Roenneberg,Cornelia M. van Duijn +78 more
TL;DR: A novel association of variants in RBFOX3 gene is reported, which shows that this gene is significantly involved in the release cycle of neurotransmitters including gamma-aminobutyric acid and various monoamines that are crucial in triggering the onset of sleep.
Journal ArticleDOI
Common variants in CLOCK are not associated with measures of sleep duration in people of European ancestry from the Sleep Heart Health Study
Jacqueline M. Lane,Jacqueline M. Lane,Archana Tare,Archana Tare,Brian E. Cade,Ting Hsu Chen,Ting Hsu Chen,Naresh M. Punjabi,Daniel J. Gottlieb,Daniel J. Gottlieb,Frank A.J.L. Scheer,Susan Redline,Richa Saxena,Richa Saxena +13 more
TL;DR: To date a variant of PER3 shown to affect diurnal preference reportedly associates with decreased REM and slow-wave sleep, and a region near MYRIP may be associated with sleep duration based on a genome-wide association study.