W
Wouter van Rheenen
Researcher at Utrecht University
Publications - 65
Citations - 7700
Wouter van Rheenen is an academic researcher from Utrecht University. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Genome-wide association study. The author has an hindex of 28, co-authored 53 publications receiving 5929 citations. Previous affiliations of Wouter van Rheenen include University Medical Center Utrecht.
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Journal ArticleDOI
Evidence for an oligogenic basis of amyotrophic lateral sclerosis
Marka van Blitterswijk,Michael A. van Es,Eric A. M. Hennekam,Dennis Dooijes,Wouter van Rheenen,Jelena Medic,Pierre R. Bourque,Helenius J. Schelhaas,Anneke J. van der Kooi,Marianne de Visser,Paul I.W. de Bakker,Jan H. Veldink,Leonard H. van den Berg +12 more
TL;DR: Evidence for an oligogenic aetiology of ALS is provided and may have important implications for the interpretation of whole exome/genome experiments designed to identify new ALS-associated genes and for genetic counselling, especially of unaffected family members.
Journal ArticleDOI
Population genetic differentiation of height and body mass index across Europe
Matthew R. Robinson,Gibran Hemani,Carolina Medina-Gomez,Massimo Mezzavilla,Tõnu Esko,Tõnu Esko,Tõnu Esko,Konstantin Shakhbazov,Joseph E. Powell,Anna A. E. Vinkhuyzen,Sonja I. Berndt,Stefan Gustafsson,Anne E. Justice,Bratati Kahali,Adam E. Locke,Tune H. Pers,Tune H. Pers,Tune H. Pers,Sailaja Vedantam,Sailaja Vedantam,Andrew R. Wood,Wouter van Rheenen,Ole A. Andreassen,Paolo Gasparini,Andres Metspalu,Leonard H. van den Berg,Jan H. Veldink,Fernando Rivadeneira,Thomas Werge,Thomas Werge,Gonçalo R. Abecasis,Dorret I. Boomsma,Dorret I. Boomsma,Daniel I. Chasman,Eco J. C. de Geus,Eco J. C. de Geus,Timothy M. Frayling,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Jouke-Jan Hottenga,Jouke-Jan Hottenga,Erik Ingelsson,Erik Ingelsson,Ruth J. F. Loos,Ruth J. F. Loos,Patrik K. E. Magnusson,Nicholas G. Martin,Grant W. Montgomery,Kari E. North,Kari E. North,Nancy L. Pedersen,Tim D. Spector,Elizabeth K. Speliotes,Michael E. Goddard,Michael E. Goddard,Jian Yang,Peter M. Visscher +57 more
TL;DR: It is found that many independent loci contribute to population genetic differences in height and body mass index in 9,416 individuals across 14 European countries.
Journal ArticleDOI
Genetic correlations of polygenic disease traits: from theory to practice
TL;DR: Improved methodologies have enabled genetic correlations to be estimated for almost any trait pair, which can improve the understanding of the shared biology and causal relationships between traits.
Journal ArticleDOI
NEK1 variants confer susceptibility to amyotrophic lateral sclerosis
Kevin P. Kenna,Perry T.C. van Doormaal,Annelot M. Dekker,Nicola Ticozzi,Brendan J. Kenna,Frank P. Diekstra,Wouter van Rheenen,Kristel R van Eijk,Ashley R. Jones,Pamela Keagle,Aleksey Shatunov,William Sproviero,Bradley N. Smith,Michael A van Es,Simon Topp,Aoife Kenna,Jack W. Miller,Claudia Fallini,Cinzia Tiloca,Russell L. McLaughlin,Caroline Vance,Claire Troakes,Claudia Colombrita,Gabriele Mora,Andrea Calvo,Federico Verde,Safa Al-Sarraj,Andrew T. King,Daniela Calini,Jacqueline de Belleroche,Frank Baas,Anneke J. van der Kooi,Marianne de Visser,Anneloor L.M.A. ten Asbroek,Peter C. Sapp,Diane McKenna-Yasek,Meraida Polak,Seneshaw Asress,José Luis Muñoz-Blanco,Tim M. Strom,Thomas Meitinger,Karen E. Morrison,Giuseppe Lauria,Kelly L. Williams,P. Nigel Leigh,Garth A. Nicholson,Garth A. Nicholson,Ian P. Blair,Claire S. Leblond,Patrick A. Dion,Guy A. Rouleau,Hardev Pall,Hardev Pall,Pamela J. Shaw,Martin R Turner,Kevin Talbot,Franco Taroni,Kevin B. Boylan,Marka van Blitterswijk,Rosa Rademakers,Jesús Esteban-Pérez,Alberto García-Redondo,Phillip Van Damme,Wim Robberecht,Adriano Chiò,Cinzia Gellera,Carsten Drepper,Michael Sendtner,Antonia Ratti,Jonathan D. Glass,Jesus S. Mora,Nazli Basak,Orla Hardiman,Albert C. Ludolph,Peter M. Andersen,Jochen H. Weishaupt,Robert H. Brown,Ammar Al-Chalabi,Vincenzo Silani,Christopher Shaw,Leonard H. van den Berg,Jan H. Veldink,John Landers +82 more
TL;DR: In a new screening strategy, gene-burden analyses trained with established ALS genes are performed and a significant association between loss-of-function (LOF) NEK1 variants and FALS risk is identified.
Journal ArticleDOI
Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis
Michael A. van Es,Helenius J. Schelhaas,Paul W.J. van Vught,Nicola Ticozzi,Nicola Ticozzi,Peter M. Andersen,Ewout J N Groen,Claudia Schulte,Hylke M. Blauw,Max Koppers,Frank P. Diekstra,Katsumi Fumoto,Ashley Lyn Leclerc,Pamela Keagle,Bastiaan R. Bloem,Hans Scheffer,Bart F.L. van Nuenen,Marka van Blitterswijk,Wouter van Rheenen,Anne-Marie Wills,Patrick Lowe,Guo-fu Hu,Wenhao Yu,Hiroko Kishikawa,David M. Wu,Rebecca D. Folkerth,Claudio Mariani,Stefano Goldwurm,Gianni Pezzoli,Philip Van Damme,Robin Lemmens,Caroline Dahlberg,Anna Birve,Rubén Fernández-Santiago,Stefan Waibel,Christine Klein,Markus Weber,Anneke J. van der Kooi,Marianne de Visser,Dagmar Verbaan,Jacobus J. van Hilten,Peter Heutink,Eric A. M. Hennekam,Edwin Cuppen,Daniela Berg,Robert H. Brown,Vincenzo Silani,Thomas Gasser,Albert C. Ludolph,Wim Robberecht,Roel A. Ophoff,Jan H. Veldink,R. Jeroen Pasterkamp,Paul I.W. de Bakker,John Landers,Bart P.C. van de Warrenburg,Leonard H. van den Berg +56 more
TL;DR: This work investigated whether ANG variants could predispose to both ALS and PD, and found a few ALS patients carrying ANG variants also showed signs of Parkinson disease.