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X. Huang
Researcher at Pennsylvania State University
Publications - 3
Citations - 606
X. Huang is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Genome-wide association study & Candidate gene. The author has an hindex of 3, co-authored 3 publications receiving 559 citations.
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Journal ArticleDOI
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
Alexandra Beilina,Iakov N. Rudenko,Alice Kaganovich,Laura Civiero,H. Chau,Suneil K. Kalia,Lorraine V. Kalia,Evy Lobbestael,Ruth Chia,Kelechi Ndukwe,J. Ding,Mike A. Nalls,Maciej B. Olszewski,David N. Hauser,Ravindran Kumaran,Andres M. Lozano,Veerle Baekelandt,Lois E. Greene,Jean-Marc Taymans,Elisa Greggio,M. R. Cookson,Vincent Plagnol,Maria Martinez,Dena G. Hernandez,Dena G. Hernandez,Manu Sharma,UM Sheerin,Mohamad Saad,Javier Simón-Sánchez,Claudia Schulte,Suzanne Lesage,Suzanne Lesage,Suzanne Lesage,S. Sveinbjornsdottir,S. Sveinbjornsdottir,Sampath Arepalli,Roger A. Barker,Yoav Ben-Shlomo,Henk W. Berendse,Daniela Berg,Kailash P. Bhatia,R. M. A. de Bie,Alessandra Biffi,Alessandra Biffi,B.R. Bloem,Zoltán Bochdanovits,Michael Bonin,Jose Bras,Kathrin Brockmann,Janet Brooks,David J. Burn,Gavin Charlesworth,Honglei Chen,Sean Chong,Carl E Clarke,J. M. Cooper,Jean-Christophe Corvol,Carl Counsell,P. Damier,J. F. Dartigues,Panagiotis Deloukas,Günther Deuschl,David T. Dexter,K.D. van Dijk,Allissa Dillman,F. Durif,Alexandra Durr,Sarah Edkins,Jonathan R. Evans,Thomas Foltynie,Jiali Gao,M. Gardner,J. R. Gibbs,J. R. Gibbs,A. Goate,Emma Gray,Rita Guerreiro,Omar Gustafsson,Omar Gustafsson,Clare Elizabeth Harris,J.J. van Hilten,Albert Hofman,Albert R. Hollenbeck,Janice L. Holton,Michele T.M. Hu,X. Huang,Heiko Huber,Gavin Hudson,Sarah E. Hunt,Johanna Huttenlocher,Thomas Illig,H. Z. Munchen,Palmi V. Jonsson,Jean-Charles Lambert,Jean-Charles Lambert,Cordelia Langford,Andrew J. Lees,Peter Lichtner,Patricia Limousin,Grisel Lopez,Delia Lorenz,Alisdair McNeill,C. Moorby,Matthew Moore,Huw R. Morris,Karen E. Morrison,Karen E. Morrison,Ese E. Mudanohwo,Sean S. O'Sullivan,James A. Pearson,Joel S. Perlmutter,H. Petursson,H. Petursson,Pierre Pollak,Bart Post,Simon C. Potter,Bernard Ravina,Tamas Revesz,Olaf Riess,Fernando Rivadeneira,Patrizia Rizzu,Mina Ryten,Stephen Sawcer,Anthony H.V. Schapira,Hans Scheffer,K. Shaw,Ira Shoulson,Ellen Sidransky,C Smith,Chris C. A. Spencer,Hreinn Stefansson,Stacy Steinberg,Joanne D. Stockton,A. Strange,Kevin Talbot,Caroline M. Tanner,Avazeh Tashakkori-Ghanbaria,François Tison,Daniah Trabzuni,Bryan J. Traynor,André G. Uitterlinden,Daan C. Velseboer,Marie Vidailhet,Marie Vidailhet,R. Walker,B.P.C. van de Warrenburg,M M Wickremaratchi,Nigel Williams,Caroline H. Williams-Gray,Sophie Winder-Rhodes,Kari Stefansson,John Hardy,Peter Heutink,Alexis Brice,T. Gasser,T. Gasser,Andrew B. Singleton,Nicholas W. Wood,Patrick F. Chinnery,Luigi Ferrucci,Robert L. Johnson,Dan L. Longo,Elisa Majounie,Richard O'Brien,Juan C. Troncoso,M. Van Der Brug,H. R. Zielke,H. R. Zielke,Alan B. Zonderman +168 more
TL;DR: It is shown, using the specific example of Parkinson disease, that identification of protein–protein interactions can help determine the most likely candidate for several GWAS loci, and proposed that three different genes for PD have a common biological function.
Journal ArticleDOI
A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease
Vincent Plagnol,Mike A. Nalls,Jose Bras,Dena G. Hernandez,Dena G. Hernandez,M. Sharma,Una-Marie Sheerin,Mohamad Saad,Javier Simón-Sánchez,Claudia Schulte,Suzanne Lesage,Suzanne Lesage,Sigurlaug Sveinbjörnsdóttir,Philippe Amouyel,Philippe Amouyel,S. Arepalli,Roger A. Barker,C. Bellinguez,Yoav Ben-Shlomo,Henk W. Berendse,Daniela Berg,Kailash P. Bhatia,R. M. A. de Bie,Alessandro Biffi,Alessandro Biffi,B.R. Bloem,Zoltán Bochdanovits,Michael Bonin,Knut Brockmann,J. Brooks,David J. Burn,Gavin Charlesworth,Honglei Chen,Patrick F. Chinnery,Sean Chong,Carl E Clarke,Carl E Clarke,Mark R. Cookson,J. M. Cooper,Jean-Christophe Corvol,Carl Counsell,P. Damier,J. F. Dartigues,Panagiotis Deloukas,Günther Deuschl,David T. Dexter,K.D. van Dijk,Allissa Dillman,F. Durif,Alexandra Durr,Sarah Edkins,Jonathan R. Evans,Thomas Foltynie,Colin Freeman,Jianjun Gao,M. Gardner,J. R. Gibbs,J. R. Gibbs,A. Goate,Emma Gray,Rita Guerreiro,O. Gustafsson,Clare Elizabeth Harris,Garrett Hellenthal,J.J. van Hilten,Albert Hofman,Albert R. Hollenbeck,Janice L. Holton,Michele T.M. Hu,X. Huang,Heiko Huber,Gavin Hudson,Sarah E. Hunt,J. Huttenlocher,Thomas Illig,Palmi V. Jonsson,Cordelia Langford,Andrew J. Lees,Peter Lichtner,Patricia Limousin,Grisel Lopez,Delia Lorenz,Alisdair McNeill,C. Moorby,Matthew Moore,Huw R. Morris,Karen E. Morrison,Karen E. Morrison,Ese E. Mudanohwo,Sean S. O'Sullivan,J. P. Pearson,R. Pearson,Joel S. Perlmutter,H. Petursson,Matti Pirinen,Pierre Pollak,Bart Post,Simon C. Potter,Bernard Ravina,Tamas Revesz,O. Riess,Fernando Rivadeneira,Patrizia Rizzu,Mina Ryten,Stephen Sawcer,Peter Heutink,Nicholas W. Wood +106 more
TL;DR: Using a dataset of post-mortem brain samples assayed for gene expression and methylation, methylation and expression changes associated with PD risk variants in PARK16/1q32, GPNMB/7p15, and STX1B/16p11 loci are identified, suggesting potential molecular mechanisms and candidate genes at these risk loci.
Using genome-Wwide complex trait analysis to quantify 'missing heritability' in Parkinson's disease
Margaux F. Keller,Mohamad Saad,Jose Bras,F. Bettella,N. Nicolaou,Javier Simón-Sánchez,F. Mittag,F. Büchel,Manu Sharma,J. R. Gibbs,Claudia Schulte,Valentina Moskvina,Alexandra Durr,Peter Holmans,L. L. Kilarski,Rita Guerreiro,Dena G. Hernandez,Alexis Brice,P. Ylikotila,Hreinn Stefansson,K. Majamaa,Huw R. Morris,Nigel Williams,T. Gasser,Peter Heutink,Nicholas W. Wood,John Hardy,Maria Martinez,Andrew B. Singleton,Michael A. Nalls,Vincent Plagnol,UM Sheerin,Suzanne Lesage,Sigurlaug Sveinbjörnsdóttir,Sampath Arepalli,Roger A. Barker,Yoav Ben-Shlomo,Henk W. Berendse,Daniela Berg,Kailash P. Bhatia,R. M. A. de Bie,Alessandra Biffi,B.R. Bloem,Zoltán Bochdanovits,Michael Bonin,Knut Brockmann,Janet Brooks,David J. Burn,Gavin Charlesworth,Honglei Chen,Patrick F. Chinnery,Sean Chong,Carl E Clarke,M. R. Cookson,J. M. Cooper,Jean-Christophe Corvol,Carl Counsell,P. Damier,J. F. Dartigues,Panagiotis Deloukas,Günther Deuschl,David T. Dexter,K.D. van Dijk,Allissa Dillman,F. Durif,Sarah Edkins,Jonathan R. Evans,Thomas Foltynie,Jiali Gao,M. Gardner,A. Goate,Erin Gray,Omar Gustafsson,Clare Elizabeth Harris,J.J. van Hilten,Albert Hofman,Albert R. Hollenbeck,Janice L. Holton,Michele T.M. Hu,X. Huang,Heiko Huber,Gavin Hudson,Sarah E. Hunt,Johanna Huttenlocher,Thomas Illig,Palmi V. Jonsson,Jean-Charles Lambert,Cordelia Langford,Andrew J. Lees,Peter Lichtner,Patricia Limousin,Grisel Lopez,Delia Lorenz,Alisdair McNeill,C. Moorby,Matthew Moore,Karen E. Morrison,Ese E. Mudanohwo,Sean S. O'Sullivan,James A. Pearson,Joel S. Perlmutter,H. Petursson,Pierre Pollak,Bart Post,Simon C. Potter,Bernard Ravina,Tamas Revesz,O. Riess,Fernando Rivadeneira,Patrizia Rizzu,Mina Ryten,Stephen Sawcer,Anthony H.V. Schapira,Hans Scheffer,K. Shaw,Ira Shoulson,Ellen Sidransky,C Smith,C. C. A. Spencer,Stacy Steinberg,Joanne D. Stockton,A. Strange,Kevin Talbot,Caroline M. Tanner,Avazeh Tashakkori-Ghanbaria,François Tison,Daniah Trabzuni,Bryan J. Traynor,André G. Uitterlinden,Daan C. Velseboer,Marie Vidailhet,R. Walker,B.P.C. van de Warrenburg,M M Wickremaratchi,Caroline H. Williams-Gray,Sophie Winder-Rhodes,K. Stefansson,Peter Donnelly,Inês Barroso,Jenefer M. Blackwell,Elvira Bramon,Matthew A. Brown,Juan P. Casas,Aiden Corvin,Audrey Duncanson,Janusz Jankowski,Hugh S. Markus,Christopher G. Mathew,Colin N. A. Palmer,Robert Plomin,Anna Rautanen,Richard C. Trembath,Ananth C. Viswanathan,Céline Bellenguez,Colin Freeman,Garrett Hellenthal,Eleni Giannoulatou,Matti Pirinen,Richard G. Pearson,Z. Su,Damjan Vukcevic,R. Gwilliam,H. D. Blackburn,Suzannah Bumpstead,Serge Dronov,Matthew W. Gillman,Naomi Hammond,Alagurevathi Jayakumar,O. T. McCann,Jennifer Liddle,Radhi Ravindrarajah,Michelle Ricketts,Matthew Waller,Paul A. Weston,Sara Widaa,Pamela Whittaker,Mark I. McCarthy +176 more
TL;DR: The results suggest that although GWASs are a useful tool in identifying the most common variants associated with complex disease, a great deal of common variants of small effect remain to be discovered.