E
Ese E. Mudanohwo
Researcher at University College London
Publications - 14
Citations - 1413
Ese E. Mudanohwo is an academic researcher from University College London. The author has contributed to research in topics: Mitochondrial disease & Genome-wide association study. The author has an hindex of 10, co-authored 14 publications receiving 1273 citations. Previous affiliations of Ese E. Mudanohwo include UCL Institute of Neurology.
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Journal ArticleDOI
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
Alexandra Beilina,Iakov N. Rudenko,Alice Kaganovich,Laura Civiero,H. Chau,Suneil K. Kalia,Lorraine V. Kalia,Evy Lobbestael,Ruth Chia,Kelechi Ndukwe,J. Ding,Mike A. Nalls,Maciej B. Olszewski,David N. Hauser,Ravindran Kumaran,Andres M. Lozano,Veerle Baekelandt,Lois E. Greene,Jean-Marc Taymans,Elisa Greggio,M. R. Cookson,Vincent Plagnol,Maria Martinez,Dena G. Hernandez,Dena G. Hernandez,Manu Sharma,UM Sheerin,Mohamad Saad,Javier Simón-Sánchez,Claudia Schulte,Suzanne Lesage,Suzanne Lesage,Suzanne Lesage,S. Sveinbjornsdottir,S. Sveinbjornsdottir,Sampath Arepalli,Roger A. Barker,Yoav Ben-Shlomo,Henk W. Berendse,Daniela Berg,Kailash P. Bhatia,R. M. A. de Bie,Alessandra Biffi,Alessandra Biffi,B.R. Bloem,Zoltán Bochdanovits,Michael Bonin,Jose Bras,Kathrin Brockmann,Janet Brooks,David J. Burn,Gavin Charlesworth,Honglei Chen,Sean Chong,Carl E Clarke,J. M. Cooper,Jean-Christophe Corvol,Carl Counsell,P. Damier,J. F. Dartigues,Panagiotis Deloukas,Günther Deuschl,David T. Dexter,K.D. van Dijk,Allissa Dillman,F. Durif,Alexandra Durr,Sarah Edkins,Jonathan R. Evans,Thomas Foltynie,Jiali Gao,M. Gardner,J. R. Gibbs,J. R. Gibbs,A. Goate,Emma Gray,Rita Guerreiro,Omar Gustafsson,Omar Gustafsson,Clare Elizabeth Harris,J.J. van Hilten,Albert Hofman,Albert R. Hollenbeck,Janice L. Holton,Michele T.M. Hu,X. Huang,Heiko Huber,Gavin Hudson,Sarah E. Hunt,Johanna Huttenlocher,Thomas Illig,H. Z. Munchen,Palmi V. Jonsson,Jean-Charles Lambert,Jean-Charles Lambert,Cordelia Langford,Andrew J. Lees,Peter Lichtner,Patricia Limousin,Grisel Lopez,Delia Lorenz,Alisdair McNeill,C. Moorby,Matthew Moore,Huw R. Morris,Karen E. Morrison,Karen E. Morrison,Ese E. Mudanohwo,Sean S. O'Sullivan,James A. Pearson,Joel S. Perlmutter,H. Petursson,H. Petursson,Pierre Pollak,Bart Post,Simon C. Potter,Bernard Ravina,Tamas Revesz,Olaf Riess,Fernando Rivadeneira,Patrizia Rizzu,Mina Ryten,Stephen Sawcer,Anthony H.V. Schapira,Hans Scheffer,K. Shaw,Ira Shoulson,Ellen Sidransky,C Smith,Chris C. A. Spencer,Hreinn Stefansson,Stacy Steinberg,Joanne D. Stockton,A. Strange,Kevin Talbot,Caroline M. Tanner,Avazeh Tashakkori-Ghanbaria,François Tison,Daniah Trabzuni,Bryan J. Traynor,André G. Uitterlinden,Daan C. Velseboer,Marie Vidailhet,Marie Vidailhet,R. Walker,B.P.C. van de Warrenburg,M M Wickremaratchi,Nigel Williams,Caroline H. Williams-Gray,Sophie Winder-Rhodes,Kari Stefansson,John Hardy,Peter Heutink,Alexis Brice,T. Gasser,T. Gasser,Andrew B. Singleton,Nicholas W. Wood,Patrick F. Chinnery,Luigi Ferrucci,Robert L. Johnson,Dan L. Longo,Elisa Majounie,Richard O'Brien,Juan C. Troncoso,M. Van Der Brug,H. R. Zielke,H. R. Zielke,Alan B. Zonderman +168 more
TL;DR: It is shown, using the specific example of Parkinson disease, that identification of protein–protein interactions can help determine the most likely candidate for several GWAS loci, and proposed that three different genes for PD have a common biological function.
Journal ArticleDOI
A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease
Vincent Plagnol,Mike A. Nalls,Jose Bras,Dena G. Hernandez,Dena G. Hernandez,M. Sharma,Una-Marie Sheerin,Mohamad Saad,Javier Simón-Sánchez,Claudia Schulte,Suzanne Lesage,Suzanne Lesage,Sigurlaug Sveinbjörnsdóttir,Philippe Amouyel,Philippe Amouyel,S. Arepalli,Roger A. Barker,C. Bellinguez,Yoav Ben-Shlomo,Henk W. Berendse,Daniela Berg,Kailash P. Bhatia,R. M. A. de Bie,Alessandro Biffi,Alessandro Biffi,B.R. Bloem,Zoltán Bochdanovits,Michael Bonin,Knut Brockmann,J. Brooks,David J. Burn,Gavin Charlesworth,Honglei Chen,Patrick F. Chinnery,Sean Chong,Carl E Clarke,Carl E Clarke,Mark R. Cookson,J. M. Cooper,Jean-Christophe Corvol,Carl Counsell,P. Damier,J. F. Dartigues,Panagiotis Deloukas,Günther Deuschl,David T. Dexter,K.D. van Dijk,Allissa Dillman,F. Durif,Alexandra Durr,Sarah Edkins,Jonathan R. Evans,Thomas Foltynie,Colin Freeman,Jianjun Gao,M. Gardner,J. R. Gibbs,J. R. Gibbs,A. Goate,Emma Gray,Rita Guerreiro,O. Gustafsson,Clare Elizabeth Harris,Garrett Hellenthal,J.J. van Hilten,Albert Hofman,Albert R. Hollenbeck,Janice L. Holton,Michele T.M. Hu,X. Huang,Heiko Huber,Gavin Hudson,Sarah E. Hunt,J. Huttenlocher,Thomas Illig,Palmi V. Jonsson,Cordelia Langford,Andrew J. Lees,Peter Lichtner,Patricia Limousin,Grisel Lopez,Delia Lorenz,Alisdair McNeill,C. Moorby,Matthew Moore,Huw R. Morris,Karen E. Morrison,Karen E. Morrison,Ese E. Mudanohwo,Sean S. O'Sullivan,J. P. Pearson,R. Pearson,Joel S. Perlmutter,H. Petursson,Matti Pirinen,Pierre Pollak,Bart Post,Simon C. Potter,Bernard Ravina,Tamas Revesz,O. Riess,Fernando Rivadeneira,Patrizia Rizzu,Mina Ryten,Stephen Sawcer,Peter Heutink,Nicholas W. Wood +106 more
TL;DR: Using a dataset of post-mortem brain samples assayed for gene expression and methylation, methylation and expression changes associated with PD risk variants in PARK16/1q32, GPNMB/7p15, and STX1B/16p11 loci are identified, suggesting potential molecular mechanisms and candidate genes at these risk loci.
Journal ArticleDOI
The UK MRC Mitochondrial Disease Patient Cohort Study: clinical phenotypes associated with the m.3243A>G mutation—implications for diagnosis and management
Victoria Nesbitt,Robert D S Pitceathly,Douglass M. Turnbull,Robert W. Taylor,Mary G. Sweeney,Ese E. Mudanohwo,Shamima Rahman,Michael G. Hanna,Robert McFarland +8 more
TL;DR: The phenotypic spectrum associated with the m.3243A>G mtDNA mutation in MTTL1 is defined and guidelines for screening and for the management of confirmed cases are proposed.
Journal ArticleDOI
C9orf72 expansions are the most common genetic cause of Huntington disease phenocopies
Davina J. Hensman Moss,Mark Poulter,Jon Beck,Jason Hehir,James M. Polke,Tracy Campbell,Garry Adamson,Ese E. Mudanohwo,Peter McColgan,A Haworth,Edward J. Wild,Mary G. Sweeney,Henry Houlden,Simon Mead,Sarah J. Tabrizi +14 more
TL;DR: The known phenotype of the C9orf72 expansion is extended in both age at onset and movement disorder symptoms, and a revised clinico-genetic algorithm is proposed for the investigation of HD phenocopy patients based on these data.
Journal ArticleDOI
The C9orf72 repeat expansion itself is methylated in ALS and FTLD patients
Zhengrui Xi,Ming Zhang,Amalia C. Bruni,Raffaele Maletta,Rosanna Colao,Pietro Fratta,James M. Polke,Mary G. Sweeney,Ese E. Mudanohwo,Benedetta Nacmias,Sandro Sorbi,Maria Carmela Tartaglia,Innocenzo Rainero,Elisa Rubino,Lorenzo Pinessi,Daniela Galimberti,Ezequiel Surace,Philip McGoldrick,Paul M. McKeever,Danielle Moreno,Christine Sato,Yan Liang,Julia Keith,Lorne Zinman,Janice Robertson,Ekaterina Rogaeva +25 more
TL;DR: The results suggest that (G4C2)n-methylation might sometimes spread to the 5′-upstream region, but not vice versa, which may open up new perspectives for studying disease mechanisms, such as determining whether methylated and unmethylated repeats have the same ability to form a G-quadruplex configuration.