Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto

About: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto is a based out in . It is known for research contribution in the topics: Population & Catalysis. The organization has 2143 authors who have published 3674 publications receiving 71071 citations. The organization is also known as: FFCLRP & FFCLRP-USP.

Antitumor activity of photodynamic therapy performed with nanospheres containing zinc-phthalocyanine

Abstract: The increasing incidence of cancer and the search for more effective therapies with minimal collateral effects have prompted studies to find alternative new treatments. Among these, photodynamic therapy (PDT) has been proposed as a very promising new modality in cancer treatment with the lowest rates of side effects, revealing itself to be particularly successful when the photosensitizer is associated with nanoscaled carriers. This study aimed to design and develop a new formulation based on albumin nanospheres containing zinc-phthalocyanine tetrasulfonate (ZnPcS4-AN) for use in the PDT protocol and to investigate its antitumor activity in Swiss albino mice using the Ehrlich solid tumor as an experimental model for breast cancer. Ehrlich tumor’s volume, histopathology and morphometry were used to assess the efficacy of intratumoral injection of ZnPcS4-AN in containing tumor aggressiveness and promoting its regression, while the toxicity of possible treatments was assessed by animal weight, morphological analysis of the liver and kidneys, hemogram, and serum levels of total bilirubin, direct bilirubin, indirect bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transferase (GGT), alkaline phosphatase, creatinine and urea. In order to evaluate the efficacy of PDT, groups of animals treated with intratumoral injection of doxorubicin (Dox) were also investigated. Intratumoral injection of ZnPcS4-AN was found to be efficient in mediating PDT to refrain tumor aggressiveness and to induce its regression. Although tumor volume reduction was not significant, PDT induced a remarkable increase in the necrosis area seen in the tumor’s central region, as in other experimental groups, including tumor and Dox treated groups, but also in the tumor’s peripheral region. Further, PDT showed minimal adverse effects. Indeed, the use of ZnPcS4-AN in mediating PDT revealed anti-neoplastic activity similar to that obtained while using intratumoral Dox therapy. PDT mediated by the new formulation ZnPcS4-AN enhanced the inhibition of tumor growth while producing practically no adverse effects and thus emerges as a very promising nanotechnology-based strategy for solid cancer treatment.

Políticas de atendimento à criança pequena nos países em desenvolvimento

Abstract: Continuas mudancas economicas e culturais estao causando transformacoes no funcionamento das familias e na educacao das criancas pequenas em todas as camadas sociais. Essas transformacoes tem contribuido para o aumento da demanda e implementacao de politicas de educacao/cuidado infantil. Avancos politicos e legais tem ocorrido em varios paises, nas ultimas decadas. Esse processo configura-se sob formas diversas nos paises desenvolvidos e nos em desenvolviment o. Naqueles e, em especial, nos paises da Comunidade Europeia, as justificativas para essas politicas fundamentam-se em um discurso pelos direitos da crianca quanto ao acesso a educacao e aos bens culturais, e pela igualdade de direitos e oportunidades de homens e mulheres. Ja nos paises em desenvolvimento, o discurso para ricos e pobres e bastante diferenciado, particularmente quando estabelece politicas para expansao do atendimento. Quando o alvo e a populacao pobre, negra e de zona rural, essas politicas se pautam por um discurso da necessidade de atender pobremente a pobreza, que transparece de maneira clara nos documentos do Banco Mundial. Neste artigo, propomo-nos a fazer uma reflexao critica sobre as politicas para a infância nos paises em desenvolvimento, tomando a America Latina como estudo de caso.

On S-asymptotically ω-periodic functions and applications

Abstract: Let ( X , ‖ ⋅ ‖ ) be a Banach space and ω ∈ R . A bounded function u ∈ C ( [ 0 , ∞ ) ; X ) is called S -asymptotically ω -periodic if lim t → ∞ [ u ( t + ω ) − u ( t ) ] = 0 . In this paper, we establish conditions under which an S -asymptotically ω -periodic function is asymptotically ω -periodic and we discuss the existence of S -asymptotically ω -periodic and asymptotically ω -periodic solutions for an abstract integral equation. Some applications to partial differential equations and partial integro-differential equations are considered.

Isolation and HPLC quantitative analysis of antioxidant flavonoids from Alternanthera tenella Colla.

Abstract: Phytochemical analysis of the antioxidant ethanolic extract of Alternanthera tenella Colla led to the isolation of six flavonoids, acacetin 8-C-[alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyranoside] (1), 2"-O-alpha-L-rhamnopyranosyl-vitexin (2), 2"-O-beta-D-glucopyranosyl-vitexin (3), vitexin (4), quercetin (5) and kaempferol (6). All the structures were established by ESI-MS and NMR spectroscopic methods. Antioxidant capacity of extract, fractions and isolated compounds was determined using the oxygen radical absorbance capacity (ORAC) assay and extract, fractions and flavonoids isolated showed antioxidant activity in vitro. Moreover, the total soluble phenolic contents of the extract and fractions were measured using the Folin-Ciocalteau reagent and the quantitative analysis of flavone C-glycosides major constituents was performed by HPLC.