Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto

About: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto is a based out in . It is known for research contribution in the topics: Population & Catalysis. The organization has 2143 authors who have published 3674 publications receiving 71071 citations. The organization is also known as: FFCLRP & FFCLRP-USP.

Anomeric Effect on Geminal and Vicinal JHH NMR Coupling Constants

Abstract: Trends for geminal (2JHH) and vicinal (3JHH) nuclear magnetic resonance indirect spin−spin coupling constants, SSCCs, for 2-methylthiirane (5) and 2-methyloxirane (6) are studied both from experime...

Green synthesis from biomass

Abstract: This review describes how to apply green chemistry principles to transform biomass into several types of molecules. On the basis of selected papers published over the last three to four years, it includes the main reactions used to convert renewable feedstocks into chemical products that are potentially applicable as raw materials or synthetic intermediates in fine chemical industries with emphasis on preparative organic synthesis.

Treatment with a growth factor-protein mixture inhibits formation of mineralized nodules in osteogenic cell cultures grown on titanium.

Abstract: Despite wide clinical application, the efficacy of platelet-rich plasma (PRP) for repairing bone defects and enhancing osseointegration of metal implants is still subject of debate. This study aimed to evaluate the effects of a well-defined PRP-like mixture containing platelet-derived growth factor-BB, transforming growth factor (TGF)-beta1, TGF-beta2, albumin, fibronectin, and thrombospondin [growth factors (GFs) + proteins] on the development of the osteogenic phenotype on titanium (Ti) in vitro. Human alveolar bone-derived osteoblastic cells were subcultured on Ti discs and exposed during the first 7 days to osteogenic medium supplemented with GFs + proteins and to osteogenic medium alone thereafter up to 14 days. Control cultures were exposed to only osteogenic medium. Dose-response experiments were carried out using rat primary calvarial cells exposed to GFs + proteins and 1:10 or 1:100 dilutions of the mixture. Treated human-derived cell cultures exhibited a significantly higher number of cycling cells at days 1 and 4 and of total cells at days 4 and 7, significantly reduced alkaline phosphatase (ALP) activity at days 4, 7, and 10, and no Alizarin red-stained areas (calcium deposits) at day 14, indicating an impairment in osteoblast differentiation. Although the 1:10 and 1:100 dilutions of the mixture restored the proliferative activity of rat-derived osteogenic cells to control levels and promoted a significant increase in ALP activity at day 10 compared with GFs + proteins, mineralized nodule formation was only observed with the 1:100 dilution ( approximately 50% of the control). These results showed that a PRP-like protein mixture inhibits development of the osteogenic phenotype in both human and rat osteoblastic cell cultures grown on Ti.

NADPH Oxidase Plays a Role on Ethanol-Induced Hypertension and Reactive Oxygen Species Generation in the Vasculature

Abstract: Aims Investigate the role of NADPH oxidase on ethanol - induced hypertension and vascular oxidative stress. Methods Male Wistar rats were treated with ethanol (20% v/v). Results Apocynin (10 mg/kg/day, i.p. ) prevented ethanol-induced hypertension. The increased contractility of endothelium-intact and endothelium-denuded aortic rings from ethanol-treated rats to phenylephrine was prevented by apocynin. Ethanol consumption increased superoxide anion (O2 −) generation and lipid peroxidation and apocynin prevented these responses. The decrease on plasma and vascular nitrate/nitrite (NOx) levels induced by ethanol was not prevented by apocynin. Treatment with ethanol did not affect aortic levels of hydrogen peroxide (H2O2) or reduced glutathione (GSH). Ethanol did not alter the activities of xanthine oxidase (XO), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Ethanol increased the expression of Nox1, PKCδ, nNOS, SAPK/JNK and SOD2 in the rat aorta and apocynin prevented these responses. No difference on aortic expression of Nox2, Nox4, p47phox, Nox organizer 1 (Noxo1), eNOS and iNOS was detected after treatment with ethanol. Ethanol treatment did not alter the phosphorylation of SAPK/JNK, p38MAPK, c-Src, Rac1 or PKCδ. Conclusions The major new finding of our study is that the increased vascular generation of reactive oxygen species (ROS) induced by ethanol is related to increased vascular Nox1/NADPH oxidase expression. This mechanism is involved in vascular dysfunction and hypertension induced by ethanol. Additionally, we conclude that ethanol consumption induces the expression of different proteins that regulate vascular contraction and growth and that NADPH oxidase-derived ROS play a role in such response. Short summary The key findings of our study are that ethanol-induced hypertension is mediated by NADPH oxidase. Moreover, increased vascular Nox1 expression is related to the generation of reactive oxygen species (ROS) by ethanol. Finally, ROS induced by ethanol increase the expression of the regulatory vascular proteins.

Enamel and dentin irradiation with 9.6 μm CO2 and 2.94 μm Er:YAG lasers: bond strength evaluation

Abstract: Background and objective: The objective of this study was to evaluate the bond strength between a composite resin and dental hard tissues, which have been previously irradiated with an Er:YAG (2.94 μm) or CO2 (9.6 μm) laser. Materials and methods: A total of 156 bovine teeth were divided into 6 groups: Group 1 – Enamel control: acid etched enamel (Single Bond); Group 2 – Dentin control: acid etched dentin (Single Bond); Group 3 – Irradiated enamel (CO2 laser – 3 W) followed by acid etching; Group 4 – Irradiated dentin (CO2 laser – 3 W) followed by acid etching; Group 5 – Irradiated enamel (Er:YAG laser – 0.16 W) followed by acid etching; Group 6 – Irradiated dentin (Er:YAG laser – 0.16 W) followed by acid etching. Results: Treatment only with acid etching and also the Er:YAG laser irradiation followed by acid etching showed the highest bond strength value while the CO2 laser irradiation followed by acid etching treatment produces the lowest bond strength values in both tissues. Conclusion: Acid etching of non-irradiated and Erbium YAG laser irradiated tissues produces better adhesion than acid etching of CO2 laser irradiated surfaces.