Gandhi Institute of Technology and Management

About: Gandhi Institute of Technology and Management is a education organization based out in Visakhapatnam, Andhra Pradesh, India. It is known for research contribution in the topics: Computer science & Heat transfer. The organization has 3392 authors who have published 4043 publications receiving 29139 citations. The organization is also known as: GITAM & GITAM College.

Performance analysis and simulation of three phase voltage source inverter using basic PWM techniques

Abstract: This paper illustrates use of different Pulse Width Techniques for a three phase voltage source inverter using Matlab Simulink software These techniques help in reducing harmonic content in power supply as well as in controlling output voltage and frequency The techniques which we have demonstrated are Multiple PWM, Sinusoidal PWM (SPWM), Trapezoidal PWM, Staircase PWM, 60° PWM and Third Harmonic PWM Though these techniques are very good at reducing lower order harmonics, efficiency of an inverter can't be effectively increased due to the presence of higher order harmonics To eliminate these harmonics, a filter is designed

Biosorption of Cd+2 by green plant biomass, Araucaria heterophylla: characterization, kinetic, isotherm and thermodynamic studies

Abstract: The present study attempted to analyze the biosorption behavior of novel biosorbent, Araucaria heterophylla (green plant) biomass, to remove Cd+2 from solutions against various parameters, i.e., initial metal ion concentration, pH, temperature, sorbent dosage and biomass particle size. The maximum biosorption was found to be 90.02% at pH 5.5 and biosorption capacity (q e) of Cd+2 is 9.2506 mg g−1. The Langmuir and Freundlich equilibrium adsorption isotherms were studied and it was observed that Freundlich model is the best fit than the Langmuir model with correlation co-efficient of 0.999. Kinetic studies indicated that the biosorption process of Cd+2 well followed the pseudo-second-order model with R 2 0.999. Thermodynamic studies observed that the process is exothermic (ΔH ° negative). Free energy change (ΔG °) with negative sign reflected the feasibility and spontaneous nature of the process. The chemical functional –OH groups, CH2 stretching vibrations, C=O carbonyl group of alcohol, C=O carbonyl group of amide, P=O stretching vibrations and –CH groups were involved in the biosorption process. The XRD pattern of the A. heterophylla was found to be mostly amorphous in nature. The SEM studies showed Cd+2 biosorption on selective grains of the biosorbent. It was concluded that A. heterophylla leaf powder can be used as an effective, low-cost, and environmentally friendly biosorbent for the removal of Cd+2 from aqueous solution.

In vitro Dissolution Profile at Different Biological pH Conditions of Hydroxychloroquine Sulfate Tablets Is Available for the Treatment of COVID-19

Abstract: Hydroxychloroquine sulfate is one of an extensive series of 4-aminoquinolines with antimalarial activity Moreover, it is used for the treatment of rheumatoid arthritis Sometimes, hydroxychloroquine sulfate is beneficial for the treatment of autoimmune diseases Based on recent clinical experiments, it is exploited for the treatment of COVID-19, coronavirus across the globe The chromatogram separation was achieved by using Agilent, Zorbax C8, 250 mm x 4 6 mm i d , column The buffer consists of 0 01 M of 1-pentane sulfonic acid and 0 02% of orthophosphoric acid in purified water Mixed buffer, acetonitrile, and methanol (800:100:100 v/v) The flow rate was 1 0 ml min-1, and injection volume was 10 mul Detection was made at 254 nm by using a dual absorbance detector (DAD) The reversed-phase high-performance liquid chromatography (RP-HPLC) method has been developed and validated as per the current International Conference on Harmonization (ICH) guidelines to estimate hydroxychloroquine sulfate tablets As part of method validation, specificity, linearity, precision, and recovery parameters were verified The concentration and area relationships were linear (R 2 > 0 999) over the concentration range of 25-300 mug ml-1 for hydroxychloroquine (HCQ) The relative standard deviations for precision and intermediate precision were <1 5% The proposed RP-HPLC generic method was applied successfully to evaluate the in vitro dissolution profile with different pH conditions such as 0 1 N HCl, pH 4 5 acetate buffer, and pH 6 8 phosphate buffers as US-marketed reference products