Gandhi Institute of Technology and Management

About: Gandhi Institute of Technology and Management is a education organization based out in Visakhapatnam, Andhra Pradesh, India. It is known for research contribution in the topics: Computer science & Heat transfer. The organization has 3392 authors who have published 4043 publications receiving 29139 citations. The organization is also known as: GITAM & GITAM College.

Preparation and characterization of solid lipid nanoparticles-a review.

Abstract: In the present scenario, most of the developed and new discovered drugs are posing real challenge to the formulation scientists due to their poor aqueous solubility which in turn is responsible for poor bioavailability. One of the approach to overcome above problem is the packaging of the drug in to particulate carrier system. Among various carriers, lipid emerged as very attractive candidate because of its unique property of enhancing the bioavailability of poorly water soluble drugs. Solid lipid, one of the physical forms of lipid, is used to formulate nanoparticles, popularly known as Solid lipid nanoparticles (SLNs), as an alternative carrier system to emulsions, liposomes and polymeric micro- and nano-particles. SLNs combine advantages of the traditional systems but avoid some of their major disadvantages. This paper reviews numerous production techniques for SLNs along with their advantages and disadvantages. Special attention is paid to the characterization of the SLNs by using various analytical tools. It also emphasizes on physical state of lipid (supercooled melts, different lipid modifications).

Application of cutting fluids in machining of titanium alloys—a review

Abstract: Titanium alloys are widely used in aerospace, biomedical, and other engineering areas due to their superior properties. However, machining of titanium alloys has always been a challenge due to the high temperatures and tool wear rates. Dry machining has a limited range of permissible cutting conditions and is hence not suitable for industrial production. As a solution, flood cooling using cutting fluids is conventionally used to reduce the cutting temperatures. However, it is often discouraged in light of the associated environmental and health hazards. In order to achieve sustainable machining, different strategies for applying the cutting fluids are developed. Some of the prominent methods include minimum quantity lubrication (MQL), minimum quantity cooled lubrication (MQCL), and cryogenic cooling. This paper provides a comprehensive review of the available recent literature on such studies. Each of these techniques and results obtained in the studies has been discussed with emphasis on the advantages and limitations of each method. Major conclusions drawn are that coated carbides are better and machinability is greatly affected by the microstructure of the material. MQL certainly improved compared to other methods while cryogenic or super cooled cutting fluid application (MQCL) has been found to be better for specific situations. Use of nanofluids for titanium is not very popular among the researchers.