Institution
Gandhi Institute of Technology and Management
Education•Visakhapatnam, Andhra Pradesh, India•
About: Gandhi Institute of Technology and Management is a education organization based out in Visakhapatnam, Andhra Pradesh, India. It is known for research contribution in the topics: Computer science & Heat transfer. The organization has 3392 authors who have published 4043 publications receiving 29139 citations. The organization is also known as: GITAM & GITAM College.
Topics: Computer science, Heat transfer, Nanofluid, Dielectric, Machining
Papers published on a yearly basis
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TL;DR: In this paper, the performance of a megawatt-scale grid-connected rooftop solar photovoltaic (PV) plant installed on the building rooftops of an educational institute (GITAM Deemed to be University) located in coastal regions (longitude 83° 23' 6.54'' E and latitude 17° 48' 8.208'' N).
48 citations
TL;DR: Synthesis of CDs from natural fruit peels as an excellent carbon source for versatile applications has been demonstrated and when modified with folic acid have shown a significant potential as biological labels for cellular imaging at multiple excitations.
48 citations
TL;DR: An attempt to explore the potential of WA in attenuating IDO for immunotherapeutic tumor arresting activity and to elucidate the underlying mode of action in a computational approach strongly suggest WA as a valuable small ligand molecule with strong binding affinity toward IDO.
Abstract: Indoleamine 2,3-dioxygenase (IDO) is emerging as an important new therapeutic drug target for the treatment of cancer characterized by pathological immune suppression IDO catalyzes the rate-limiti
48 citations
TL;DR: An efficient one-pot method for the synthesis of cyanamides from dithiocarbamate salts via a double desulfurization strategy using molecular iodine is disclosed, with high yields and environmental benignity, cost effectiveness and high yields.
48 citations
TL;DR: Recent experimental evidences are focused on to support the notion that PLA2s are causally implicated in the pathobiology of cancer and inflammatory related disorders and discuss the potential utility of isoform specific PLA2 inhibitors as preventive and/or therapeutic agents.
Abstract: Phospholipase A2s (PLA2s) are group of enzymes, which cleave phospholipids specifically at sn-2 position to liberate free fatty acid, mostly arachidonic acid (AA) and lysophospholipids (LPLs). Inhibition of PLA2 prevents the liberation of AA and LPLs. Hence, researchers have been considering PLA2s could be a better therapeutic target than the downstream enzymes cyclooxygense and lipoxygenase. Several isoforms of PLA2s exist; they are mainly divided into secretory PLA2s (sPLA2), cytosolic PLA2s (cPLA2), and calcium independent PLA2s (iPLA2), platelet activating factor- acyl hydrolase (PAF-AH), lysosomal PLA2 (LPLA2), adipose-specific PLA2 (Ad- PLA). Each isoform of PLA2s is different in its chemical structure and physiological functions. sPLA2s (Groups IIA, V and X) are well characterized as proinflammatory mediating enzymes but their role in cancer is controversial. Groups IVA, IVB and IVC cPLA2s are present in humans but only Group IVA cPLA2 plays key role in pathophysiology of various cancers and inflammation. The role of iPLA2 in inflammation and cancer is limited. Lipoprotein associated PLA2 (Group VIIA PLA2), a PAF-AH isoform, has key role in atherosclerosis. Several isoform specific PLA2 inhibitors have been developed and some of the PLA2s inhibitors are currently under clinical trials for various inflammatory and oncologic diseases. This review focuses on the recent experimental evidences to support the notion that PLA2s are causally implicated in the pathobiology of cancer and inflammatory related disorders and discuss the potential utility of isoform specific PLA2 inhibitors as preventive and/or therapeutic agents.
48 citations
Authors
Showing all 3465 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Young Bae Jun | 41 | 518 | 8065 |
| Hongtan Liu | 38 | 126 | 5803 |
| Suresh Chandra Satapathy | 34 | 274 | 3853 |
| Sundar G. Bharadwaj | 34 | 87 | 9953 |
| Kavitha Srinivas | 33 | 144 | 3481 |
| Dhananjay Shukla | 29 | 122 | 2206 |
| P. V. Sivapullaiah | 29 | 135 | 2829 |
| Chakravarthula S.K. Raju | 28 | 138 | 2446 |
| Somnath Ghosh | 28 | 287 | 3318 |
| Suresh Maddila | 27 | 157 | 2727 |
| Prem Kumar Singh | 22 | 66 | 1315 |
| Mandava V. Rao | 21 | 86 | 1298 |
| Pakala K. S. Sarma | 21 | 72 | 1611 |
| Rama Rao Malla | 20 | 82 | 1330 |
| Sai S. Nudurupati | 20 | 37 | 2413 |