Gandhi Institute of Technology and Management

About: Gandhi Institute of Technology and Management is a education organization based out in Visakhapatnam, Andhra Pradesh, India. It is known for research contribution in the topics: Computer science & Heat transfer. The organization has 3392 authors who have published 4043 publications receiving 29139 citations. The organization is also known as: GITAM & GITAM College.

Experimental studies on the performance and emission parameters of a direct injection diesel engine fueled with nanoparticle-dispersed biodiesel blend

Abstract: The current work implies the influence of copper chloride (CuCl2) and cobalt chloride (CoCl2) nanoparticle dosed diesel-linseed oil biodiesel blend (B20) to assess the performance and emissions characteristics of a direct injection diesel engine. Three distinct proportions of nanoparticles were added to B20, namely 50, 75, and 100 ppm independently for CuCl2 and CoCl2. QPAN 80 dispersant was added to nanoparticles at a quantity of 100 ppm and played out an ultrasonication process. The stability test was performed in two particular periods like Day1 and Day 15. The performance concerning brake thermal efficiency (BTE) was enhanced with nanoparticle (CuCl2 and CoCl2)-dosed dispersant-mixed B20. Similarly, the brake-specific fuel consumption (BSFC) was also specified less. Besides, the emissions of carbon monoxide (CO), unburnt hydrocarbons (UHC), nitrogen oxides (NOx), and smoke emissions were seen lower with the nanoparticle addition. At the utmost load, the maximum BTE was improved by 8.28 and 5.06%, while the BSFC was reduced by 1.42 and 0.91%, respectively, for B20 + 75 ppm CuCl2 + dispersant and B20 + 75 ppm CoCl2 + dispersant. Similarly, the CO, UHC, NOx, and smoke were dropped down drastically for B20 + 75 ppm CuCl2 + dispersant by 65.7, 22.7, 40.37, and 15.5%, respectively, while for B20 + 75 ppm CoCl2 + dispersant, it was decreased by 57.1, 24.5, 39.08, and 10.07% respectively.

Zinc oxide nanoparticles as efficient catalyst for the synthesis of novel di-spiroindolizidine bisoxindoles in aqueous medium

Abstract: Developing environmentally benign synthetic protocols such as reaction in water is a major challenge. However, many of the known methods carried out in an aqueous medium are not efficient at large scale and need purification involving volatile solvents. Heterogeneous catalysis by nanoparticles in aqueous medium is a possible solution. Therefore, we tested the use of heterogeneous zinc oxide nanoparticles to catalyse the synthesis of di-spiroindolizidine bisoxindoles at room temperature by three-component condensation in an aqueous medium via azomethine ylide-mediated 1,3-dipolar cycloaddition reaction. The products were obtained with regio- and diastereoselectivities, with yields ranging from 83 to 94%, in 60 min. Absolute structures of products were confirmed by single-crystal X-ray crystallography. A gram-scale reaction along with recyclability experiment of the heterogeneous catalyst was also performed. To establish the sustainability of the reaction presented, green chemistry matrixes were calculated and found to possess a high atom economy of 96.59% and small E-factor of 0.098. The presented method has advantages such as environmental friendly reaction conditions, use of inexpensive heterogeneous zinc oxide nanoparticle as catalyst, broad substrate scope, short reaction times, quantitative yields of complex di-spiroindolizidine bisoxindoles and absence of tedious purification procedure like column chromatography.

Salidroside - Can it be a Multifunctional Drug?

Abstract: Background Salidroside is a glucoside of tyrosol found mostly in the roots of Rhodiola spp. It exhibits diverse biological and pharmacological properties. In the last decade, enormous research is conducted to explore the medicinal properties of salidroside; this research reported many activities like anti-cancer, anti-oxidant, anti-aging, anti-diabetic, anti-depressant, anti-hyperlipidemic, anti-inflammatory, immunomodulatory, etc. Objective: Despite its multiple pharmacological effects, a comprehensive review detailing its metabolism and therapeutic activities is still missing. This review aims to provide an overview of the metabolism of salidroside, its role in alleviating different metabolic disorders, diseases and its molecular interaction with the target molecules in different conditions. This review mostly concentrates on the metabolism, biological activities and molecular pathways related to various pharmacological activities of salidroside. Conclusion Salidroside is produced by a three-step pathway in the plants with tyrosol as an intermediate molecule. The molecule is biotransformed into many metabolites through phase I and II pathways. These metabolites, together with a certain amount of salidroside may be responsible for various pharmacological functions. The salidroside based inhibition of PI3k/AKT, JAK/ STAT, and MEK/ERK pathways and activation of apoptosis and autophagy are the major reasons for its anti-cancer activity. AMPK pathway modulation plays a significant role in its anti-diabetic activity. The neuroprotective activity was linked with decreased oxidative stress and increased antioxidant enzymes, Nrf2/HO-1 pathways, decreased inflammation through suppression of NF-κB pathway and PI3K/AKT pathways. These scientific findings will pave the way to clinically translate the use of salidroside as a multi-functional drug for various diseases and disorders in the near future.

On the necessity of proper quarantine without lock down for 2019-nCoV in the absence of vaccine.

Abstract: Presently the world is passing through a critical phase due to the prevalence of the Novel Corona virus, 2019-nCoV or COVID-19, which has been declared a pandemic by WHO. The virus transmits via droplets of saliva or discharge from the nose when an infected person coughs or sneezes. Due to the absence of vaccine, to prevent the disease, social distancing and proper quarantine of infected populations are needed. Non-resident citizens coming from several countries need to be quarantined for 14 days prior to their entrance. The same is to be applied for inter-state movements within a country. The purpose of this article is to propose mathematical models, based on quarantine with no lock down, that describe the dynamics of transmission and spread of the disease thereby proposing an effective preventive measure in the absence of vaccine.

Structural Studies of Multifunctional SrTiO3 Nanocatalyst Synthesized by Microwave and Oxalate Methods: Its Catalytic Application for Condensation, Hydrogenation, and Amination Reactions.

Abstract: The present study deals with the synthesis of SrTiO3 (STO) nanocatalysts by conventional oxalate and microwave-assisted hydrothermal methods. Thorough characterization of the nanocatalysts synthesi...