Gandhi Institute of Technology and Management

About: Gandhi Institute of Technology and Management is a education organization based out in Visakhapatnam, Andhra Pradesh, India. It is known for research contribution in the topics: Computer science & Heat transfer. The organization has 3392 authors who have published 4043 publications receiving 29139 citations. The organization is also known as: GITAM & GITAM College.

Cross diffusion effects on magnetohydrodynamic slip flow of Carreau liquid over a slendering sheet with non-uniform heat source/sink

Abstract: Magnetohydrodynamic flow of Carreau fluid over a slendering sheet (variable thickness) has been numerically studied by considering the multiple slips effect. Thermosolutal boundary layer analysis is also accounted in the presence of cross diffusion and non-uniform heat source/sink. The governing nonlinear coupled partial differential equations are transformed to nonlinear coupled ordinary differential equations before being integrated numerically using Runge–Kutta based Newton’s schemes. The effects of various parameters involved in the present problem were elaborately discussed with help of graphs and tables. The present results in a limiting sense are found to accord with the previous study. The present results indicate that the cross diffusion and slip parameters had a tendency to control the flow. The influence of slip is more evident in Carreau fluid case on contrast with the Newtonian fluid case.

Anticancer Effect of Rosiglitazone, a PPAR-γ Agonist against Diethylnitrosamine-Induced Lung Carcinogenesis.

Abstract: Multiple effects on cancer cells are exerted by the peroxisome proliferator-activated receptor γ (PPAR-γ). Recent studies have shown that rosiglitazone, a synthetic PPAR-γ ligand, inhibits the growth of cells. This research was designed to assess the impact of rosiglitazone on diethylnitrosamine (DENA)-induced lung carcinogenesis in Wistar rats and to study the underlying molecular mechanism. A total of 40 adult male Wistar rats were separated into four groups as follows: group 1 is known as a control. Group 2 is known as the DENA group (150 mg/kg, i.p.). Group 3 and group 4 denote DENA-induced rats treated with 5 and 10 mg/kg rosiglitazone, respectively. Lipid peroxidation, various antioxidant enzymes, histological perceptions, and caspase-3, Bcl2, and Bax gene expression were measured in lung tissues. Rosiglitazone treatment reverted the DENA-induced changes in the expression of these genes, inflammatory cytokines, and oxidative stress. However, blotting analysis discovered reduced caspase-3 and BAX expressions and elevated Bcl-2 expression in DENA-induced rats. The expression of such proteins causing DENA lung cancer was restored by rosiglitazone therapy.

Analytical Modeling and Simulation of Gate-All-Around Junctionless Mosfet for Biosensing Applications

Abstract: A new analytical model for a Junctionless Field Effect Transistor that can be used in biosensor applications is proposed in this research work. The Semiconductor device analyzed here employs a Gate-All-Around structure made of two dissimilar materials. The main objective of the surrounding gate is to reduce the Short Channel Effects owing to its scalability. This model introduces a novel dual material structure embedded with a nanocavity to make it suitable for biosensing applications. 2-D Poisson’s equation is solved using the Finite Differentiation Method to obtain the surface potential, which in turn is employed to determine the electric field and threshold voltage of the proposed structure. Finally, the biosensor sensitivity of the device is analyzed and the obtained results are verified using 2D TCAD simulations.

Homoleptic and heteroleptic Zn(II) selone catalysts for thioetherification of aryl halides without scrubbing oxygen

Abstract: Five new mononuclear tetra-coordinated zinc(II) selones, [Zn(L1)2Cl2] (1), [Zn(L1)2Br2] (2), [{Zn(L2)4}{BF4}2] (3), [{Zn(L2)4}{ClO4}2] (4), and [Zn(L2)2Br2] (5), have been isolated from a one-pot reaction between the corresponding zinc(II) salt and selone ligand, 1-methyl 3-naphthylmethylimidazoline-2-selone (L1) or 1-isopropyl 3-methylimidazoline-2-selone (L2). All these complexes were characterized by CHN analysis, FT-IR, NMR studies, and single-crystal X-ray crystallography techniques. The Zn(II) center in 1–5 exhibits a distorted tetrahedral geometry. Besides, 1–5 were employed as catalysts in the thioetherification of aryl halides. The first zinc(II) catalyst-mediated thioetherification of aryl halides without scrubbing oxygen was demonstrated. Catalysts 1–5 are highly active towards the cross-coupling reaction between aryl halides and thiophenols. The catalytic ability of 1–5 was explored in THF, toluene, and CH3CN solvents with different bases such as K2CO3, Cs2CO3, and NaOtBu. Interestingly, the zinc(II) center attached to two selone ligands is much more catalytically active than that attached to four selone ligands.

Evaluation of in Vitro Antibacterial Activity of Caralluma Lasiantha for Scientific Validation of Indian Traditional Medicine

Abstract: Caralluma lasiantha is used as a traditional medicine in India to heal body heat and inflammations. In order to find out a scientific validation for the Indian traditional knowledge, antibacterial activity of C. lasiantha extracts was studied against inflammation causing bacteria (viz., Staphylococcus aureus, Escherichia coli, Streptococcus Sp., Bacillus subtilis, Enterobacter aerogenes, Klebsiella pneumoniae) along with other Gram-positive and Gram-negative bacteria. Solvents with different polarity were used for extraction from dry roots and stems. Minimum inhibitory concentrations (MIC) were also studied. Differential antibacterial activity was exhibited by extracts and higher inhibition potential against Gram-positive bacteria was explained. The observed antibacterial activities were correlated with the chemical structures of phytochemicals present in C. lasiantha. Anti-inflammation activities are related to C. lasiantha extracts through their antibacterial activities.