Government of India

About: Government of India is a government organization based out in New Delhi, India. It is known for research contribution in the topics: Population & Government. The organization has 2945 authors who have published 2999 publications receiving 44942 citations. The organization is also known as: Union Government & Central Government.

Immunoprotective potential of Ayurvedic herb Kalmegh (Andrographis paniculata) against respiratory viral infections - LC-MS/MS and network pharmacology analysis.

Abstract: Introduction Immunity boosting has emerged as a global strategy to fight the SARS-CoV-2 pandemic situation. In India, AYUSH systems of medicine have been promoted as an immune-protection strategy. Andrographis paniculata (Burm. F) Nees (AP) mentioned in Ayurveda has been widely used for treating sore throat, flu, and upper respiratory tract infections which may provide possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways. Objectives The present work uses liquid chromatography-tandem mass spectrometry (LC-MS/MS) metabolomics and combination synergy analysis based on network pharmacology to mine multimode evidence to understand the possible mechanism of action, diseases association, protein-protein interaction and major pathways involved therein. Material and methods Metabolite profiling was performed by Agilent QTOF LC-MS/MS system. Network pharmacology analysis was performed by using functional annotation analysis based on databases like Binding DB, STRING, DAVID and KEGG for further data mining. Further combination synergy was evaluated using "neighbourhood approach" and networks were constructed through Cytoscape 3.2.1. Results The molecules from kalmegh provides immune-protection and anti-viral response via involving different pathways, like toll-like receptor pathway, PI3/AKT pathway and MAP kinase pathways against COVID-19 infection. The KEGG analysis showed that in a vast majority of the most enriched pathways, AP were associated with viral infections and upper respiratory tract infections. Conclusions The results suggest a synergy between andrographolide and other molecules identified as safe and efficacious anti-inflammatory agent having effects on upper respiratory tract infections and can significantly decrease the production of cytokines and pro-inflammatory factors in viral infections.

Developing synergy regression models with space-borne ALOS PALSAR and Landsat TM sensors for retrieving tropical forest biomass

Abstract: Forest stand biomass serves as an effective indicator for monitoring REDD (reducing emissions from deforestation and forest degradation). Optical remote sensing data have been widely used to derive forest biophysical parameters inspite of their poor sensitivity towards the forest properties. Microwave remote sensing provides a better alternative owing to its inherent ability to penetrate the forest vegetation. This study aims at developing optimal regression models for retrieving forest above-ground bole biomass (AGBB) utilising optical data from Landsat TM and microwave data from L-band of ALOS PALSAR data over Indian subcontinental tropical deciduous mixed forests located in Munger (Bihar, India). Spatial biomass models were developed. The results using Landsat TM showed poor correlation (R 2 = 0.295 and RMSE = 35 t/ha) when compared to HH polarized L-band SAR (R 2 = 0.868 and RMSE = 16.06 t/ha). However, the prediction model performed even better when both the optical and SAR were used simultaneously (R 2 = 0.892 and RMSE = 14.08 t/ha). The addition of TM metrics has positively contributed in improving PALSAR estimates of forest biomass. Hence, the study recommends the combined use of both optical and SAR sensors for better assessment of stand biomass with significant contribution towards operational forestry.

A novel approach of graphical rectangular b-metric spaces with an application to the vibrations of a vertical heavy hanging cable

Abstract: In the present article, first, we introduce the notation of graphical rectangular b-metric spaces and scrutinize some basic and topological properties of the underlying spaces. Some examples endowed with appropriate graphs are propounded to validate the established results, thereby giving a better insight into the corresponding concepts and investigations. Our results extend and improve several results in the literature. Second, by means of the obtained results, an application to the vibrations of a vertical heavy hanging cable is entrusted to manifest the viability of the obtained results. Finally, some open problems are also stated for the future scope of the study.