Government of India

About: Government of India is a government organization based out in New Delhi, India. It is known for research contribution in the topics: Population & Government. The organization has 2945 authors who have published 2999 publications receiving 44942 citations. The organization is also known as: Union Government & Central Government.

Regulation of Viral Replication, Apoptosis and Pro-Inflammatory Responses by 17-AAG during Chikungunya Virus Infection in Macrophages

Abstract: Chikungunya virus (CHIKV) infection has re-emerged as a major public health concern due to its recent worldwide epidemics and lack of control measures. Although CHIKV is known to infect macrophages, regulation of CHIKV replication, apoptosis and immune responses towards macrophages are not well understood. Accordingly, the Raw264.7 cells, a mouse macrophage cell line, were infected with CHIKV and viral replication as well as new viral progeny release was assessed by flow cytometry and plaque assay, respectively. Moreover, host immune modulation and apoptosis were studied through flow cytometry, Western blot and ELISA. Our current findings suggest that expression of CHIKV proteins were maximum at 8 hpi and the release of new viral progenies were remarkably increased around 12 hpi. The induction of Annexin V binding, cleaved caspase-3, cleaved caspase-9 and cleaved caspase-8 in CHIKV infected macrophages suggests activation of apoptosis through both intrinsic and extrinsic pathways. The pro-inflammatory mediators (TNF and IL-6) MHC-I/II and B7.2 (CD86) were also up-regulated during infection over time. Further, 17-AAG, a potential HSP90 inhibitor, was found to regulate CHIKV infection, apoptosis and pro-inflammatory cytokine/chemokine productions of host macrophages significantly. Hence, the present findings might bring new insight into the therapeutic implication in CHIKV disease biology.

Decomposition and resynthesis of the micas

Abstract: A study was made of the -decomposition of the micas muscovite, phlogopite, biotite, and lepidolite and of the vermiculite Jefferisite. Decomposition was effected by heat, water vapor under pressure, and electrodialysis. The changes were generally detected by X-ray methods supplemented by water-loss determinations, differential thermal analysis, photomicrographs, and electron micrographs. Muscovite and phlogopite were found to have similar dehydration and decomposition characteristics, whereas biotite appeared to be more stable toward heat than either. Lepidolite, after a minor decomposition, may be melted and recrystallized congruently. Jefferisite decomposed to talc at about 350 °C. Low-temperature arid low-pressure hydrothermal experiments failed to produce any marked effects No intermediate products of decomposition were isolated in the high- temperature (maximum 650°C.), high-pressure (maximum 10,000 Ib. per sq. in.) experiments. It was possible to resynthesize muscovite and phlogopite from their decomposition products. Electrodklysis was used for the first time as a tool for decomposing biotite and jefferisite in stages, finally reaching a silica gel. Other possible applications for electrodialysis were investigated.

Unique perforated graphene derived from Bougainvillea flowers for high-power supercapacitors: a green approach

Abstract: Herein, we demonstrated a green approach for the synthesis of high surface area (850 m2 g−1) mesoporous perforated graphene (PG) from Bougainvillea flower for the first time using a template free single-step method. The existence of PG was confirmed by XRD, Raman spectroscopy, FESEM, and FETEM. Surprisingly, FETEM clearly showed 5–10 nm perforation on the graphene sheets. More significantly, these mesoporous perforated graphene sheets can be produced in large scale using the present green approach. Considering high surface area and unique perforated graphene architecture, these PGs were studied for supercapacitor applications in detail without any chemical or physical activation. The nanoporosity and high conductivity of PG derived from Bougainvillea flower exhibited excellent supercapacitive performance. According to the supercapacitor study, the synthesized perforated graphene sheets conferred a very high specific capacitance of 458 F g−1 and an energy density of 63.7 Wh kg−1 at the power density of around 273.2 Wh kg−1 in aqueous 1 M Na2SO4. Significantly, the areal capacitance of PG was observed to be very high, i.e. 67.2 mF cm−2. The cyclability study results showed excellent stability of synthesized perforated graphene sheets up to 10000 cycles. Note that the specific and areal capacitance and the energy density of the synthesized PGs are much higher than the earlier reported values. The high supercapacitive performance may be due to high surface area and mesoporosity of PG. The present approach has a good potential to produce cheaper and high surface area PG. These PGs are good candidates as an anode material in the lithium-ion battery.

Portable lidar system for atmospheric boundary layer measurements

Abstract: A portable lidar system has been developed for monitoring the evolution of the atmospheric boundary layer (ABL) using aerosols as the tracers of atmospheric motion. This lidar system utilizes state-of-the-art technology with a high repetition rate, low pulse energy laser, and photon-counting detection. The system is capable of continuous, autonomous data acquisition in both daytime and nighttime. During daytime, the aerosol profiles measured with the lidar are found to have sufficient signal strength to observe the structure of the ABL, which plays an important role in air pollution phenomena. The time series of the range-squared signal has been used for the interpretation of the ABL dynamics.

Cobalt Cyclotetraphosphate (Co2P4O12): A New High-Performance Electrode Material for Supercapacitors

Abstract: Recently, transition metal phosphates (TMPs) are demonstrated as promising candidates for supercapacitors due to their good conductivity and long-term stability. Herein, we have inrtoduced cobalt cyclotetraphosphate (Co2P4O12) as novel supercapacitive electrode material, which deliver a capacitance of 437 F/g with good stability over 3000 cycles (around 90%). To display the practical relevance, we have fabricated asymmetric device using activated carbon and Co2P4O12 as negative and positive electrodes, respecitvely, which can be operated up to 1.4 V. The introduction of redox-active moieties (such as potassium iodide (KI)) in parent KOH solution enhances the capacitance from 120 F/g to 156 F/g for Co2P4O12//AC cell with extended voltage window (1.8 V). Owing to the additional voltage and advancement in the capacitance, the cell delivers battery-level energy of 70 Wh/kg at power density of 2.3 kW/kg. It should be emphasized that even at high power (7.6 kW/kg), the cell maintained very good specific energy of 48 Wh/kg, suggesting excellent rate performance. The asymmetric device further showed long cycling stability with negligible loss and excellent Coulombic efficiency over 5000 cycles. Thus, metal cyclotetraphosphate can be employed as a promising electrode material in energy storage systems.