Institution
Government of India
Government•New Delhi, India•
About: Government of India is a government organization based out in New Delhi, India. It is known for research contribution in the topics: Population & Government. The organization has 2945 authors who have published 2999 publications receiving 44942 citations. The organization is also known as: Union Government & Central Government.
Topics: Population, Government, Health care, Public health, Dielectric
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the microplastics were identified as polystyrene polymers in the soft tissues of the commercially important bivalve Perna viridis and examined by microscopic and DXR Raman spectroscopic methods.
73 citations
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TL;DR: The almond skin powder is one of the biodegradable and biocompatible food wastes that can be used as reinforcement in polylactic acid (PLA) for preparation of biomedical scaffolds/implants as mentioned in this paper.
Abstract: The almond skin powder is one of the biodegradable and biocompatible food wastes that can be used as reinforcement in polylactic acid (PLA) for preparation of biomedical scaffolds/implants (for hig...
73 citations
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TL;DR: The uptake of AB from NE was significantly higher than AB suspension especially in heart with a drug targeting index of 44.1%, also confirming the efficacy of nanosized formulation at therapeutic site.
Abstract: Nanoemulsion (NE) of amlodipine besilate (AB) was developed by spontaneous emulsification method with the aim to enhance the solubility and oral bioavailability of AB and to achieve localized delivery of drug at target site. Pseudoternary phase diagrams were constructed to identify the NE region. The selected formulations from NE region were subjected to droplet size analysis, partitioning study and in vitro drug release. The partition coefficient was calculated and correlated with percent dissolution efficiency as a tool to predict in vitro drug release from NEs. The release of drug from NEs was significantly higher (p < 0.01) than the marketed tablet formulation. The optimal formulation contained 15% Labrafil M, 35% [Tween 80: ethanol (2:1)], and 50% by weight aqueous phase (NE3) was characterized by transmission electron microscopy (TEM) and for thermodynamic stability. The pharmacokinetics and biodistribution studies of the optimized radiolabeled formulation (99mTc-labeled) in mice (p.o.) demonstrated a relative bioavailability of 475% against AB suspension. In almost all the tested organs, the uptake of AB from NE was significantly higher (p < 0.05) than AB suspension especially in heart with a drug targeting index of 44.1%, also confirming the efficacy of nanosized formulation at therapeutic site. A three times increase in the overall residence time of NE further signifies the advantage of NEs as drug carriers for enhancing bioavailability of AB.
73 citations
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TL;DR: Although both lysine and arginine based homopeptides condense DNA via electrostatic interactions, they follow different pattern of DNA condensation and release in vitro, showing that the cellular uptake of the complexes and their intracellular state seem to be controlled by the peptide chemistry.
Abstract: Designing of nanocarriers that can efficiently deliver therapeutic DNA payload and allow its smooth intracellular release for transgene expression is still a major constraint. The optimization of DNA nanocarriers requires thorough understanding of the chemical and structural characteristics of the vector–nucleic acid complexes and its correlation with the cellular entry, intracellular state and transfection efficiency. l-Lysine and l-arginine based cationic peptides alone or in conjugation with other vectors are known to be putative DNA delivery agents. Here we have used l-lysine and l-arginine homopeptides of three different lengths and probed their DNA condensation and release properties by using a multitude of biophysical techniques including fluorescence spectroscopy, gel electrophoresis and atomic force microscopy. Our results clearly showed that although both lysine and arginine based homopeptides condense DNA via electrostatic interactions, they follow different pattern of DNA condensation and rele...
73 citations
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TL;DR: In this paper, a template free facile hydrothermal synthesis of hierarchical nanostructured Mn1−xNixCo2O4 with excellent supercapacitive performance is reported.
72 citations
Authors
Showing all 2961 results
Name | H-index | Papers | Citations |
---|---|---|---|
M. Santosh | 103 | 1344 | 49846 |
Rakesh Kumar | 91 | 1959 | 39017 |
Sankaran Subramanian | 74 | 332 | 24680 |
S. V. Subramanian | 72 | 444 | 17132 |
Amit Kumar | 65 | 1618 | 19277 |
Arvind Subramanian | 64 | 220 | 20452 |
Rakesh Sharma | 60 | 673 | 14157 |
Anil Mishra | 55 | 178 | 10505 |
Kaushik Basu | 54 | 323 | 13030 |
Pulok K. Mukherjee | 54 | 296 | 10873 |
Maharaj K. Bhan | 53 | 207 | 11841 |
Kuldeep Singh | 51 | 431 | 11815 |
Rakesh Tuli | 47 | 165 | 7497 |
Dipak Kumar Sahoo | 47 | 234 | 7293 |
M. Rajeevan | 46 | 164 | 9115 |