Hasanuddin University

About: Hasanuddin University is a education organization based out in Makassar, Indonesia. It is known for research contribution in the topics: Population & Medicine. The organization has 5839 authors who have published 5267 publications receiving 25893 citations. The organization is also known as: Universitas Hasanuddin.

Induction of Apoptosis and Subsequent Phagocytosis of Virus-Infected Cells As an Antiviral Mechanism

Abstract: Viruses are infectious entities that hijack host replication machineries to produce their progeny, resulting, in most cases, in disease and, sometimes, in death in infected host organisms. Hosts are equipped with an array of defense mechanisms that span from innate to adaptive as well as from humoral to cellular immune responses. We previously demonstrated that mouse cells underwent apoptosis in response to influenza virus infection. These apoptotic, virus-infected cells were then targeted for engulfment by macrophages and neutrophils. We more recently reported similar findings in the fruit fly Drosophila melanogaster, which lacks adaptive immunity, after an infection with Drosophila C virus. In these experiments, the inhibition of phagocytosis led to severe influenza pathologies in mice and early death in Drosophila. Therefore, the induction of apoptosis and subsequent phagocytosis of virus-infected cells appear to be an antiviral innate immune mechanism that is conserved among multicellular organisms. We herein discuss the underlying mechanisms and significance of the apoptosis-dependent phagocytosis of virus-infected cells. Investigations on the molecular and cellular features responsible for this underrepresented virus-host interaction may provide a promising avenue for the discovery of novel substances that are targeted in medical treatments against virus-induced intractable diseases.

Design a smart waste bin for smart waste management

Abstract: In this paper, we presented the smart waste-bin that can managed the waste in a smart city project. The system consist of sensors to measure the weight of waste and the level of waste inside the bin. The system also adapt with network environment, to manage all information from waste management. As the result we proposed a prototype of smart waste-bin that suitable for many kind of conventional waste-bin.

Large-scale coral reef rehabilitation after blast fishing in Indonesia

Abstract: The severely degraded condition of many coral reefs worldwide calls for active interventions to rehabilitate their physical and biological structure and function, in addition to effective management of fisheries and no‐take reserves. Rehabilitation efforts to stabilize reef substratum sufficiently to support coral growth have been limited in size. We documented a large coral reef rehabilitation in Indonesia aiming to restore ecosystem functions by increasing live coral cover on a reef severely damaged by blast fishing and coral mining. The project deployed small, modular, open structures to stabilize rubble and to support transplanted coral fragments. Between 2013 to 2015, approximately 11,000 structures covering 7,000 m² were deployed over 2 ha of a reef at a cost of US$174,000. Live coral cover on the structures increased from less than 10% initially to greater than 60% depending on depth, deployment date and location, and disturbances. The mean live coral cover in the rehabilitation area in October 2017 was higher than reported for reefs in many other areas in the Coral Triangle, including marine protected areas, but lower than in the no‐take reference reef. At least 42 coral species were observed growing on the structures. Surprisingly, during the massive coral bleaching in other regions during the 2014–2016 El Nino–Southern Oscillation event, bleaching in the rehabilitation area was less than 5% cover despite warm water (≥30°C). This project demonstrates that coral rehabilitation is achievable over large scales where coral reefs have been severely damaged and are under continuous anthropogenic disturbances in warming waters.

Oldest cave art found in Sulawesi

Abstract: Indonesia harbors some of the oldest known surviving cave art. Previously, the earliest dated rock art from this region was a figurative painting of a Sulawesi warty pig (Sus celebensis). This image from Leang Bulu’ Sipong 4 in the limestone karsts of Maros-Pangkep, South Sulawesi, was created at least 43,900 years ago (43.9 ka) based on Uranium-series dating. Here, we report the Uranium-series dating of two figurative cave paintings of Sulawesi warty pigs recently discovered in the same karst area. The oldest, with a minimum age of 45.5 ka, is from Leang Tedongnge. The second image, from Leang Balangajia 1, dates to at least 32 ka. To our knowledge, the animal painting from Leang Tedongnge is the earliest known representational work of art in the world. There is no reason to suppose, however, that this early rock art is a unique example in Island Southeast Asia or the wider region.

COMPARISON BETWEEN HYDRO- AND OSMO-PRIMING TO DETERMINE PERIOD NEEDED FOR PRIMING INDICATOR AND ITS EFFECT ON GERMINATION PERCENTAGE OF AEROBIC RICE CULTIVARS (Oryza sativa L.)

Abstract: This study compared hydro- and osmo-priming to determine period needed for seed priming indicator to emerge and its effect against water stress on germination percentage of some aerobic rice cultivars ( Oryza sativa L.). Experiments were arranged in completely randomized design using three aerobic rice cultivars and PEG with four replications. Rice varieties (Inpago-8, IR64 and Situ Bagendit) were combined with four different PEG concentrations. Drought stress was simulated by different PEG solutions and with distilled water as control. Results indicated differentiations between hydro and on priming indicator time, while varietal difference was not significant. Fastest recorded time was obtained between 30-36 hours under hydro priming, PEG 100 g L -1 (63-69 hours) and 83-93 hours in PEG 200 g L -1 solution. Thus showing increased solution concentration led to prolonged priming indicator time. The highest germination percentage was obtained in Situ Bagendit treated with PEG 200 mg L -1 (90.25%) and the lowest obtained in Inpago-8 (75.75%) under control. It is better to use osmo-priming (PEG 200 g L -1 ) for teaching aerobic rice seed against drought stress. More research is needed to confirm benefits of seed treatment with PEG to cultivated crops under water stress, drought and salinity conditions.