Hasanuddin University

About: Hasanuddin University is a education organization based out in Makassar, Indonesia. It is known for research contribution in the topics: Population & Medicine. The organization has 5839 authors who have published 5267 publications receiving 25893 citations. The organization is also known as: Universitas Hasanuddin.

Role of dentists in indonesian disaster victim identification operations: religious & cultural aspects

Abstract: Indonesia is the largest archipelago in the world, consisting of five main islands and 17,500 smaller islands, spread across three seismic belts that run throughout the country. Indonesia is extremely prone to disasters, both natural and manmade. With a total population of nearly 250 million people, Indonesia’s Muslim community exceeds 180 million ‐ the largest Muslim population in the world. On December 26, 2004 an earthquake and tsunami hit Aceh resulting in an estimated 165,00 deaths (mostly Muslims) and half a million people displaced. The members of the Disaster Victim Identification (DVI) operations faced unique obstacles. Speed was required because families wished to bury their relatives within 24 hours (before the next prayer time) and the hot tropical climate caused rapid decomposition of bodies. At the same time, survivors needed medical help; there was total destruction of facilities; minimal equipment; ante mortem data destroyed by the flood; and no electricity, transportation, water or food. DVI was of necessity basic so that the team of 33 could process tens of thousands of victims. Lessons were learnt including the need to involve religions leaders immediately; revise the DVI protocols that were designed for manmade (and smaller) mass disasters; provision of individual cameras, laptops and portable x-ray devices; and attention to more efficient use of mass graves.

Osteoprotegerin Is more than a Possible Serum Marker in Liver Fibrosis: A Study into Its Function in Human and Murine Liver

Abstract: Osteoprotegerin (OPG) serum levels are associated with liver fibrogenesis and have been proposed as a biomarker for diagnosis. However, the source and role of OPG in liver fibrosis are unknown, as is the question of whether OPG expression responds to treatment. Therefore, we aimed to elucidate the fibrotic regulation of OPG production and its possible function in human and mouse livers. OPG levels were significantly higher in lysates of human and mouse fibrotic livers compared to healthy livers. Hepatic OPG expression localized in cirrhotic collagenous bands in and around myofibroblasts. Single cell sequencing of murine liver cells showed hepatic stellate cells (HSC) to be the main producers of OPG in healthy livers. Using mouse precision-cut liver slices, we found OPG production induced by transforming growth factor β1 (TGFβ1) stimulation. Moreover, OPG itself stimulated expression of genes associated with fibrogenesis in liver slices through TGFβ1, suggesting profibrotic activity of OPG. Resolution of fibrosis in mice was associated with decreased production of OPG compared to ongoing fibrosis. OPG may stimulate fibrogenesis through TGFβ1 and is associated with the degree of fibrogenesis. It should therefore be investigated further as a possible drug target for liver fibrosis or biomarker for treatment success of novel antifibrotics.

Uncertainty principles for the continuous shearlet transforms in arbitrary space dimensions

Abstract: The aim of this article is to formulate some new uncertainty principles for the continuous shearlet transforms in arbitrary space dimensions. Firstly, we derive an analogue of Pitt's inequality for...

Genetic Risk Factors for Colorectal Cancer in Multiethnic Indonesians

Abstract: Purpose Colorectal cancer is a common cancer in Indonesia, yet it has been understudied. We conduct a genome-wide association study focused on evaluation and discovery of colorectal cancer risk factors in Indonesians. Methods We administered detailed questionnaires and collecting blood samples from 162 colorectal cancer cases throughout Makassar, Indonesia. We also established a control set of 193 healthy individuals frequency matched by age, sex, and ethnicity. A genome-wide association analysis was performed on 84 cases and 89 controls passing quality control. We evaluated known colorectal cancer genetic variants using logistic regression and established a genome-wide polygenic risk model using a Bayesian variable selection technique. Results We replicate associations for rs9497673, rs6936461 and rs7758229 on chromosome 6; rs11255841 on chromosome 10; and rs4779584, rs11632715, and rs73376930 on chromosome 15. Polygenic modeling identified 10 SNP associated with colorectal cancer risk. Conclusions This work helps characterize the relationship between variants in the SCL22A3, SCG5, GREM1, and STXBP5-AS1 genes and colorectal cancer in a diverse Indonesian population. With further biobanking and international research collaborations, variants specific to colorectal cancer risk in Indonesians will be identified.