Hasanuddin University

About: Hasanuddin University is a education organization based out in Makassar, Indonesia. It is known for research contribution in the topics: Population & Medicine. The organization has 5839 authors who have published 5267 publications receiving 25893 citations. The organization is also known as: Universitas Hasanuddin.

Anti-IL-6 receptor antibody treatment for severe COVID-19 and the potential implication of IL-6 gene polymorphisms in novel coronavirus pneumonia

Abstract: Although severe acute respiratory virus 2 (SARS-CoV-2)-infected patients tend to present with mild to moderate symptoms, some may develop severe or life-threatening disease. There remains an urgent need for efficacious management of COVID-19, because despite current ongoing clinical treatment trials, no effective treatments have been reported. Previously, our analysis demonstrated that excessive inflammatory responses, marked by an elevated level of interleukin-6 (IL-6) and C- reactive protein (CRP), are strongly associated with COVID-19 progression. Moreover, there is also a probable association between the disease progression observed in COVID-19 with IL-6 gene polymorphism. This article summarizes the cumulative evidence on the efficacy of anti-IL-6 receptor (anti-IL-6R) antibody among severe COVID-19-infected patients. Additionally, a meta-analysis was also performed to estimate the association between IL-6 gene polymorphism with predisposition as well as disease severity of pneumonia in general. Our analysis confirmed that anti-IL-6R antibody treatment could effectively treat severe COVID-19-infected patients, marked by suppression of CRP and improvement of clinical symptoms. The second analysis showed that although IL- 6 gene polymorphism did not predispose to pneumonia, carrier status of the IL-6–174C allele is associated with a higher level of IL-6 production and pneumonia severity. Altogether, our study strengthens the notion that IL-6 plays a pivotal role in COVID-19 progression, and suppression of IL-6 signalling cascade shows a promising therapy in severe forms of SARS-CoV-2 infection.

Reflection electron energy loss spectroscopy for ultrathin gate oxide materials

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Distribution of Voltage-Gated Sodium Channel (Nav) Alleles among the Aedes aegypti Populations In Central Java Province and Its Association with Resistance to Pyrethroid Insecticides.

Abstract: The emergence of insecticide resistant Aedes aegypti mosquitoes has hampered dengue control efforts. WHO susceptibility tests, using several pyrethroid compounds, were conducted on Ae. aegypti larvae that were collected and raised to adulthood from Semarang, Surakarta, Kudus and Jepara in Java. The AaNaV gene fragment encompassing kdr polymorphic sites from both susceptible and resistant mosquitoes was amplified, and polymorphisms were associated with the resistant phenotype. The insecticide susceptibility tests demonstrated Ae, aegypti resistance to the pyrethroids, with mortality rates ranging from 1.6%-15.2%. Three non-synonymous polymorphisms (S989P, V1016G and F1534C) and one synonymous polymorphism (codon 982) were detected in the AaNaV gene. Eight AaNaV alleles were observed in specimens from Central Java. Allele 3 (SGF) and allele 7 (PGF) represent the most common alleles found and demonstrated strong associations with resistance to pyrethroids (OR = 2.75, CI: 0.97-7.8 and OR = 7.37, CI: 2.4-22.5, respectively). This is the first report of 8 Ae. aegypti AaNaV alleles, and it indicates the development of resistance in Ae. aegypti in response to pyrethroid insecticide-based selective pressure. These findings strongly suggest the need for an appropriate integrated use of insecticides in the region. The 989P, 1016G and 1534C polymorphisms in the AaNaV gene are potentially valuable molecular markers for pyrethroid insecticide resistance monitoring.

Design of smart lock system for doors with special features using bluetooth technology

Abstract: Nowadays the use of Internet of Things (IoT) technology has developed that almost all aspects in human's life utilize IoT technology to increase the quality of life. Lock system is one of those aspects that has been impacted by the massive development of IoT, for example lock system that can be opened or closed by entering the password or by gadget to control it. The main component of smart home concept lays on the door, so the door lock system becomes an interesting topic to discuss. The paper presents a design of lock system for operating door without a control to open or lock it that brings a comfort and can be applied effectively. Besides, the lock system can be used for all kinds of human's physical condition. The system uses bluetooth technology with low power and is available on almost all gadgets. The design of the system is also completed with special feature to increase the security and the comfort of the users. The lock system indirectly supports the program of United Convention of Right People with Disabilities.