Hospital General Universitario Gregorio Marañón

About: Hospital General Universitario Gregorio Marañón is a healthcare organization based out in Madrid, Spain. It is known for research contribution in the topics: Population & Transplantation. The organization has 11975 authors who have published 12386 publications receiving 244847 citations.

Immunological and clinical differences between juvenile and adult onset of systemic lupus erythematosus

Abstract: Introduction: Systemic lupus erythematosus (SLE) in children usually follows a more severe course than in adults, but sometimes in the previous studies reported there are many confounding factorsObjective: To analyse the immunological and clinical characteristics of SLE juvenile onset and SLE adult onset.Methods: We studied 179 patients with SLE, 49 patients were aged 6 – 18 yrs at onset of disease. Anti-dsDNA antibodies were detected by radioimmunoassay and antibodies to extractable nuclear antigens (ENA): anti-nRNP, anti-Sm, anti-Ro/SS-A and anti-La/SS-B antibodies by ELISA, counterimmuno-electrophoresis and immunoblotting.Results: Juvenile-onset SLE shows a higher frequency of cutaneous vasculitis (44.8% vs 27.6%; P < 0.05), seizures (18.3% vs 7.6%; P < 0.05) nephropathy (67.3% vs 48.4%; P < 0.025), and discoid lupus erythematosus (26.5% vs 13.8%; P < 0.05). The incidence of articular manifestations is lower than in adults (85.7% vs 96.1%; P < 0.025). No significant differences were found between the t...

Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2

Abstract: Late in 2020, two genetically-distinct clusters of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with mutations of biological concern were reported, one in the United Kingdom and one in South Africa. Using a combination of data from routine surveillance, genomic sequencing and international travel we track the international dispersal of lineages B.1.1.7 and B.1.351 (variant 501Y-V2). We account for potential biases in genomic surveillance efforts by including passenger volumes from location of where the lineage was first reported, London and South Africa respectively. Using the software tool grinch (global report investigating novel coronavirus haplotypes), we track the international spread of lineages of concern with automated daily reports, Further, we have built a custom tracking website (cov-lineages.org/global_report.html) which hosts this daily report and will continue to include novel SARS-CoV-2 lineages of concern as they are detected.

Estudio PREVENCAT: control del riesgo cardiovascular en atención primaria

Abstract: Fundamento y objetivo: Muchos estudios de factores de riesgo cardiovascular (FRCV) realizados en nuestro medio se centran en solo uno El estudio PREVENCAT se diseno para estimar el control de los principales FRCV en poblacion asistida en atencion primaria que presenta hipertension arterial (HTA), diabetes mellitus tipo 2 (DM-2) y/o hipercolesterolemia (HC) y para conocer la prevalencia de sindrome metabolico en estos pacientes Pacientes y metodo: Estudio multicentrico, transversal, en pacientes con HTA, DM-2 y/o HC, reclutados de forma consecutiva por medicos de atencion primaria en Espana Se evaluaron la presion arterial, el colesterol, la glucemia basal, la obesidad, el tabaquismo y el ejercicio fisico, y se estimaron el grado de control de estos FRCV y la prevalencia del sindrome metabolico Resultados: Se incluyo en el estudio a 2649 pacientes (un 51,6% mujeres) con una media (desviacion estandar) de edad de 64 (11,3) anos de edad El diagnostico mas frecuente fue la HTA (78,9%), seguido de HC (58,4%) y de DM-2 (37,4%) En toda la muestra, el porcentaje de pacientes que tenia bien controlada o basalmente normal la presion arterial, el colesterol y la glucemia basal fue del 40,0% (intervalo de confianza [IC] del 95%, 38,2-41,9), del 42,6% (IC del 95%, 40,5-44,7) y del 62,7% (IC del 95%, 60,8-64,5), respectivamente El 15,6% de los casos (IC del 95%, 14,3-17,0) tenia un indice de masa corporal menor o igual a 25 kg/m2, el 87,5% no fumaba en la actualidad (IC del 95%, 86,2-88,8) y el 46,2% practicaba ejercicio fisico regular (IC del 95%, 44,3-48,1) El 40% de los pacientes presentaba 2 o menos FRCV bien controlados La prevalencia del sindrome metabolico fue del 50,6% (IC del 95%, 48,7-52,5) Conclusiones: El control de los FRCV considerados en poblacion atendida en atencion primaria es insuficiente Apenas uno de cada 2 pacientes con HTA, DM-2 o HC esta controlado El control del sobrepeso y el sedentarismo es aun peor