Institution
Instituto Politécnico Nacional
Education•Mexico City, Mexico•
About: Instituto Politécnico Nacional is a education organization based out in Mexico City, Mexico. It is known for research contribution in the topics: Population & Context (language use). The organization has 43351 authors who have published 63315 publications receiving 938532 citations. The organization is also known as: Instituto Politécnico Nacional & Instituto Politecnico Nacional.
Topics: Population, Context (language use), Catalysis, Control theory, Thin film
Papers published on a yearly basis
Papers
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TL;DR: The present review had as its objective the collecting of data based on research conducted into some fruits and plants, which are consumed frequently by humans and which have demonstrated hepatoprotective capacity, as well as an analysis of a resin and some phytochemicals extracted from fruits, plants, yeasts, and algae.
Abstract: The liver is one of the most important organs in the body, performing a fundamental role in the regulation of diverse processes, among which the metabolism, secretion, storage, and detoxification of endogenous and exogenous substances are prominent. Due to these functions, hepatic diseases continue to be among the main threats to public health, and they remain problems throughout the world. Despite enormous advances in modern medicine, there are no completely effective drugs that stimulate hepatic function, that offer complete protection of the organ, or that help to regenerate hepatic cells. Thus, it is necessary to identify pharmaceutical alternatives for the treatment of liver diseases, with the aim of these alternatives being more effective and less toxic. The use of some plants and the consumption of different fruits have played basic roles in human health care, and diverse scientific investigations have indicated that, in those plants and fruits so identified, their beneficial effects can be attributed to the presence of chemical compounds that are called phytochemicals. The present review had as its objective the collecting of data based on research conducted into some fruits (grapefruit, cranberries, and grapes) and plants [cactus pear (nopal) and cactus pear fruit, chamomile, silymarin, and spirulina], which are consumed frequently by humans and which have demonstrated hepatoprotective capacity, as well as an analysis of a resin (propolis) and some phytochemicals extracted from fruits, plants, yeasts, and algae, which have been evaluated in different models of hepatotoxicity.
265 citations
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TL;DR: The electrochemical behavior of passive films formed on one austenitic stainless steel and one ferritic stainless steel (AISI 446) in solutions with pH between 0.6 and 8.4 was studied by capacitance measurements and photocurrent spectroscopy.
265 citations
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TL;DR: The microalgal biomass, which has a high lipid and pigment content (mainly carotenoids), was submitted to supercritical CO2 extraction and was effectively used as feedstock to produce biohydrogen through dark fermentation by Enterobacter aerogenes resulting in a hydrogen production yield of 60.6 mL/g dry biomass.
263 citations
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TL;DR: An automated, high-throughput screen identified auranofin, a US Food and Drug Administration (FDA)-approved drug used therapeutically for rheumatoid arthritis, as active against E. histolytica in culture and markedly decreased the number of parasites, the detrimental host inflammatory response and hepatic damage.
Abstract: Entamoeba histolytica, a protozoan intestinal parasite, is the causative agent of human amebiasis. Amebiasis is the fourth leading cause of death and the third leading cause of morbidity due to protozoan infections worldwide(1), resulting in ~70,000 deaths annually. E. histolytica has been listed by the National Institutes of Health as a category B priority biodefense pathogen in the United States. Treatment relies on metronidazole(2), which has adverse effects(3), and potential resistance of E. histolytica to the drug is an increasing concern(4,5). To facilitate drug screening for this anaerobic protozoan, we developed and validated an automated, high-throughput screen (HTS). This screen identified auranofin, a US Food and Drug Administration (FDA)-approved drug used therapeutically for rheumatoid arthritis, as active against E. histolytica in culture. Auranofin was ten times more potent against E. histolytica than metronidazole. Transcriptional profiling and thioredoxin reductase assays suggested that auranofin targets the E. histolytica thioredoxin reductase, preventing the reduction of thioredoxin and enhancing sensitivity of trophozoites to reactive oxygen-mediated killing. In a mouse model of amebic colitis and a hamster model of amebic liver abscess, oral auranofin markedly decreased the number of parasites, the detrimental host inflammatory response and hepatic damage. This new use of auranofin represents a promising therapy for amebiasis, and the drug has been granted orphan-drug status from the FDA.
262 citations
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TL;DR: Results showed that there is no correlation between the studied commercial mushrooms and the corresponding mycelia obtained in vitro, and this study contributes to the rise of data relatively to the species consumed as fresh mushroom and the possibility of their in vitro production as a source of bioactive compounds.
262 citations
Authors
Showing all 43548 results
Name | H-index | Papers | Citations |
---|---|---|---|
Giacomo Bruno | 158 | 1687 | 124368 |
Giuseppe Mancia | 145 | 1369 | 139692 |
Giorgio Maggi | 135 | 1323 | 90270 |
Salvatore Nuzzo | 133 | 1533 | 91600 |
Giuseppe Iaselli | 133 | 1514 | 91558 |
Marcello Abbrescia | 132 | 1400 | 84486 |
Louis Antonelli | 132 | 1089 | 83916 |
Donato Creanza | 132 | 1452 | 89206 |
Alexis Pompili | 131 | 1437 | 86312 |
Gabriella Pugliese | 131 | 1309 | 88714 |
Giovanna Selvaggi | 131 | 1159 | 83274 |
Heriberto Castilla-Valdez | 130 | 1659 | 93912 |
Ricardo Lopez-Fernandez | 129 | 1213 | 81575 |
Cesare Calabria | 128 | 1095 | 76784 |
Paolo Vitulo | 128 | 1120 | 79498 |