Institution
Instituto Politécnico Nacional
Education•Mexico City, Mexico•
About: Instituto Politécnico Nacional is a education organization based out in Mexico City, Mexico. It is known for research contribution in the topics: Population & Context (language use). The organization has 43351 authors who have published 63315 publications receiving 938532 citations. The organization is also known as: Instituto Politécnico Nacional & Instituto Politecnico Nacional.
Topics: Population, Context (language use), Catalysis, Control theory, Thin film
Papers published on a yearly basis
Papers
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TL;DR: This work will review the compounds with antitumor potential identified so far in mushrooms, including low-molecular-weight (LMW, e.g. quinones, cerebrosides, isoflavones, catechols, amines, triacylglycerols, sesquiterpenes, steroids, organic germanium and selenium).
Abstract: For thousands of years medicine and natural products have been closely linked through the use of traditional medicines and natural poisons. Mushrooms have an established history of use in traditional oriental medicine, where most medicinal mushroom preparations are regarded as a tonic, that is, they have beneficial health effects without known negative side-effects and can be moderately used on a regular basis without harm. Mushrooms comprise a vast and yet largely untapped source of powerful new pharmaceutical products. In particular, and most importantly for modern medicine, they represent an unlimited source of compounds which are modulators of tumour cell growth. Furthermore, they may have potential as functional foods and sources of novel molecules. We will review the compounds with antitumor potential identified so far in mushrooms, including low-molecular-weight (LMW, e.g. quinones, cerebrosides, isoflavones, catechols, amines, triacylglycerols, sesquiterpenes, steroids, organic germanium and selenium) and high-molecular-weight compounds (HMW, e.g. homo and heteroglucans, glycans, glycoproteins, glycopeptides, proteoglycans, proteins and RNA-protein complexes).
296 citations
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TL;DR: In this paper, the authors presented a catalog of hard Fermi-LAT sources (2FHLs) in the 50 GeV-2 TeV energy range and found that 86% of the sources can be associated with counterparts at other wavelengths, of which the majority are active galactic nuclei and the rest (11%) are Galactic sources.
Abstract: We present a catalog of sources detected above 50 GeV by the Fermi-Large Area Telescope (LAT) in 80 months of data. The newly delivered Pass 8 event-level analysis allows the detection and characterization of sources in the 50 GeV–2 TeV energy range. In this energy band, Fermi-LAT has detected 360 sources, which constitute the second catalog of hard Fermi-LAT sources (2FHL). The improved angular resolution enables the precise localization of point sources (~1farcm7 radius at 68% C. L.) and the detection and characterization of spatially extended sources. We find that 86% of the sources can be associated with counterparts at other wavelengths, of which the majority (75%) are active galactic nuclei and the rest (11%) are Galactic sources. Only 25% of the 2FHL sources have been previously detected by Cherenkov telescopes, implying that the 2FHL provides a reservoir of candidates to be followed up at very high energies. This work closes the energy gap between the observations performed at GeV energies by Fermi-LAT on orbit and the observations performed at higher energies by Cherenkov telescopes from the ground.
296 citations
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Istituto Nazionale di Fisica Nucleare1, Santa Cruz Institute for Particle Physics2, Max Planck Society3, SLAC National Accelerator Laboratory4, University of Pisa5, Instituto Politécnico Nacional6, University of Trieste7, University of Maryland, College Park8, Goddard Space Flight Center9, University of Denver10, Iowa State University11, Universities Space Research Association12
TL;DR: In this article, the authors discuss several interpretations of the Fermi results based either on a single large scale Galactic CRE component or by invoking additional electron-positron primary sources, e.g. nearby pulsars or particle dark matter annihilation.
295 citations
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TL;DR: This review summarises the use of essential oils in the control of postharvest diseases of horticultural commodities, their mode of actions, effects on the defence mechanism and quality of fresh fruit.
295 citations
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Federal University of Rio de Janeiro1, Simon Fraser University2, National University of La Plata3, Oswaldo Cruz Foundation4, Washington University in St. Louis5, University of the Republic6, European Bioinformatics Institute7, National Institutes of Health8, Federal University of Uberlandia9, Universidade Federal de Minas Gerais10, Sao Paulo State University11, State University of Norte Fluminense12, Johns Hopkins University13, University of Notre Dame14, Universidade Federal Rural do Rio de Janeiro15, Pompeu Fabra University16, Centre national de la recherche scientifique17, University of Toronto18, Centers for Disease Control and Prevention19, Instituto Politécnico Nacional20, Florida International University21, Universidade Federal do Espírito Santo22, University of Illinois at Urbana–Champaign23, University of Santiago de Compostela24, Virginia Tech25, University of Cambridge26, University of Manitoba27
TL;DR: The first genome sequence of a nondipteran insect vector of an important human parasitic disease is described, which provides critical information on the physiology and evolution of this important vector species and should be instrumental for the development of innovative disease control methods.
Abstract: Rhodnius prolixus not only has served as a model organism for the study of insect physiology, but also is a major vector of Chagas disease, an illness that affects approximately seven million people worldwide. We sequenced the genome of R. prolixus, generated assembled sequences covering 95% of the genome (∼ 702 Mb), including 15,456 putative protein-coding genes, and completed comprehensive genomic analyses of this obligate blood-feeding insect. Although immune-deficiency (IMD)-mediated immune responses were observed, R. prolixus putatively lacks key components of the IMD pathway, suggesting a reorganization of the canonical immune signaling network. Although both Toll and IMD effectors controlled intestinal microbiota, neither affected Trypanosoma cruzi, the causal agent of Chagas disease, implying the existence of evasion or tolerance mechanisms. R. prolixus has experienced an extensive loss of selenoprotein genes, with its repertoire reduced to only two proteins, one of which is a selenocysteine-based glutathione peroxidase, the first found in insects. The genome contained actively transcribed, horizontally transferred genes from Wolbachia sp., which showed evidence of codon use evolution toward the insect use pattern. Comparative protein analyses revealed many lineage-specific expansions and putative gene absences in R. prolixus, including tandem expansions of genes related to chemoreception, feeding, and digestion that possibly contributed to the evolution of a blood-feeding lifestyle. The genome assembly and these associated analyses provide critical information on the physiology and evolution of this important vector species and should be instrumental for the development of innovative disease control methods.
293 citations
Authors
Showing all 43548 results
Name | H-index | Papers | Citations |
---|---|---|---|
Giacomo Bruno | 158 | 1687 | 124368 |
Giuseppe Mancia | 145 | 1369 | 139692 |
Giorgio Maggi | 135 | 1323 | 90270 |
Salvatore Nuzzo | 133 | 1533 | 91600 |
Giuseppe Iaselli | 133 | 1514 | 91558 |
Marcello Abbrescia | 132 | 1400 | 84486 |
Louis Antonelli | 132 | 1089 | 83916 |
Donato Creanza | 132 | 1452 | 89206 |
Alexis Pompili | 131 | 1437 | 86312 |
Gabriella Pugliese | 131 | 1309 | 88714 |
Giovanna Selvaggi | 131 | 1159 | 83274 |
Heriberto Castilla-Valdez | 130 | 1659 | 93912 |
Ricardo Lopez-Fernandez | 129 | 1213 | 81575 |
Cesare Calabria | 128 | 1095 | 76784 |
Paolo Vitulo | 128 | 1120 | 79498 |