Institution
Universidade Federal de Santa Catarina
Education•Florianópolis, Brazil•
About: Universidade Federal de Santa Catarina is a education organization based out in Florianópolis, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 28408 authors who have published 55433 publications receiving 714461 citations.
Papers published on a yearly basis
Papers
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TL;DR: Findings show that delta9-THC impairs spatial discrimination learning in a selective way in the water maze in mice and that these deficits may be mediated by cannabinoid receptors.
Abstract: This study reports a series of spatial discrimination procedures in a Morris-type maze to investigate the effects of delta9-tetrahydrocannabinol (delta9-THC) on different phases of learning and memory in mice. Adult male mice were given training trails to find the submerged platform at a fixed location in the water maze adapted for mice. In additional experiments, mice were trained with the repeated acquisition procedure to test the working memory. Results indicate that delta9-THC (8 mg/kg i.p.) 30 min pretest impaired specifically the acquisition of spatial learning and the performance of mice in the working memory task, while consolidation and retrieval of a previously learned task were not affected. There was no evidence of motoric difficulty, as the number of quadrant line crossings was not decreased and no visible sign of sensorimotor disturbance was observed during swimming. Pretreatment with SR 141716A (1 mg/kg i.p.), a CB1 cannabinoid receptor antagonist, significantly prevented the learning deficits in the water maze. These findings show that delta9-THC impairs spatial discrimination learning in a selective way in the water maze in mice and that these deficits may be mediated by cannabinoid receptors.
113 citations
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TL;DR: In this paper, a case-based research approach was adopted to explore the cleaner production principles and practices adopted by a manufacturing company located in an emerging economy in order to understand how these were valuable in fostering circular economy implementation.
113 citations
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TL;DR: In this article, a series of statements based on their own investigations is given as "facts" and another series of statement is made as "fictions" related to erroneous proposals on the functioning of modifiers and coatings in the pertinent literature.
113 citations
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TL;DR: By acting in cooperation and in a coordinated, timely manner, TNF-α, IL-1β, neutrophils, and the transcription factor NF-κB are major and essential players in the ability of LPS to induce B1 receptor expression in vivo.
Abstract: Several studies have now clearly established the ability of LPS to induce bradykinin B(1) receptor up-regulation in vivo and the functional relevance of this up-regulation for the pathophysiological effects of LPS. Using an in vivo system in which LPS is injected locally into the rat paw, we have examined the potential contribution of proinflammatory cytokines, NF-kappaB activation, and neutrophil influx for the functional and molecular up-regulation of the bradykinin B(1) receptor. Treatment with LPS resulted in a rapid and sustained functional up-regulation of B(1) receptors in the rat paw that correlated with the increase in B(1) receptor mRNA levels. B(1) receptor up-regulation is preceded by the rapid activation of the transcription factor NF-kappaB and the production of proinflammatory cytokines, including TNF-alpha and IL-1beta. More importantly, blockade of NF-kappaB translocation, TNF-alpha, or IL-1beta prevented the functional and molecular up-regulation of B(1) receptors. Injection of LPS also induced the influx of neutrophils that followed the peak of cytokine production and associated with the persistent activation of NF-kappaB and functional B(1) receptor up-regulation. Blockade of neutrophil influx with platelet-activating factor receptor antagonists or cell adhesion molecule blockers prevented B(1) receptor up-regulation. Thus, by acting in cooperation and in a coordinated, timely manner, TNF-alpha, IL-1beta, neutrophils, and the transcription factor NF-kappaB are major and essential players in the ability of LPS to induce B(1) receptor expression in vivo.
112 citations
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TL;DR: People not affiliated with the dairy industry appeared to hold an ethic for dairy farming that included concern for the animal, as well as economic, social, and environmental aspects of the dairy system.
112 citations
Authors
Showing all 28762 results
Name | H-index | Papers | Citations |
---|---|---|---|
Richard Vidal | 113 | 685 | 61464 |
Carlos A. Peres | 101 | 434 | 33582 |
Pedro J. J. Alvarez | 89 | 378 | 34837 |
Hans J. Herrmann | 87 | 999 | 30760 |
Elson Longo | 86 | 1454 | 40494 |
Anthony H. Dickenson | 86 | 353 | 24982 |
Kannan Govindan | 83 | 309 | 23633 |
João B. Calixto | 81 | 460 | 23029 |
Walter Herzog | 79 | 672 | 23816 |
Alírio E. Rodrigues | 79 | 832 | 28848 |
Domenico Girelli | 72 | 349 | 23968 |
Larry Davidson | 69 | 459 | 20177 |
Diogo O. Souza | 68 | 534 | 17793 |
David Kirk | 67 | 303 | 14177 |
Felipe Dal-Pizzol | 65 | 380 | 13171 |