Institution
Universidade Federal de Santa Catarina
Education•Florianópolis, Brazil•
About: Universidade Federal de Santa Catarina is a education organization based out in Florianópolis, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 28408 authors who have published 55433 publications receiving 714461 citations.
Papers published on a yearly basis
Papers
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TL;DR: The predominant biomarkers used by toxicologists and epidemiologists to evaluate exposure, effect and susceptibility to Hg compounds are described, and the applicability of these parameters in risk assessment is examined.
Abstract: Mercury (Hg) toxicity continues to represent a global health concern. Given that human populations are mostly exposed to low chronic levels of mercurial compounds (methylmercury through fish, mercury vapor from dental amalgams, and ethylmercury from vaccines), the need for more sensitive and refined tools to assess the effects and/or susceptibility to adverse metal-mediated health risks remains. Traditional biomarkers, such as hair or blood Hg levels, are practical and provide a reliable measure of exposure, but given intra-population variability, it is difficult to establish accurate cause-effect relationships. It is therefore important to identify and validate biomarkers that are predictive of early adverse effects prior to adverse health outcomes becoming irreversible. This review describes the predominant biomarkers used by toxicologists and epidemiologists to evaluate exposure, effect and susceptibility to Hg compounds, weighing on their advantages and disadvantages. Most importantly, and in light of recent findings on the molecular mechanisms underlying Hg-mediated toxicity, potential novel biomarkers that might be predictive of toxic effect are presented, and the applicability of these parameters in risk assessment is examined.
146 citations
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TL;DR: Consumption of GT, a beverage rich in polyphenols, may offer protection against the oxidative damage caused by exercise, and dietary guidance for sports participants should be emphasized.
146 citations
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TL;DR: The chloroform fraction showed the best and methanolic the worst antitumor activity and the antiproliferative potential of the crude extract and fractions was investigated in vivo using the Ehrlich ascites carcinoma.
146 citations
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TL;DR: It is found that in mice with partial sciatic nerve ligation, TRPA1 silencing in nociceptors attenuated mechanical allodynia, without affecting macrophage infiltration and oxidative stress, whereasTRPA1silencing in Schwann cells reduced both allodynian and neuroinflammation.
Abstract: It is known that transient receptor potential ankyrin 1 (TRPA1) channels, expressed by nociceptors, contribute to neuropathic pain. Here we show that TRPA1 is also expressed in Schwann cells. We found that in mice with partial sciatic nerve ligation, TRPA1 silencing in nociceptors attenuated mechanical allodynia, without affecting macrophage infiltration and oxidative stress, whereas TRPA1 silencing in Schwann cells reduced both allodynia and neuroinflammation. Activation of Schwann cell TRPA1 evoked NADPH oxidase 1 (NOX1)-dependent H2O2 release, and silencing or blocking Schwann cell NOX1 attenuated nerve injury-induced macrophage infiltration, oxidative stress and allodynia. Furthermore, the NOX2-dependent oxidative burst, produced by macrophages recruited to the perineural space activated the TRPA1-NOX1 pathway in Schwann cells, but not TRPA1 in nociceptors. Schwann cell TRPA1 generates a spatially constrained gradient of oxidative stress, which maintains macrophage infiltration to the injured nerve, and sends paracrine signals to activate TRPA1 of ensheathed nociceptors to sustain mechanical allodynia.
145 citations
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TL;DR: Dung beetle species with different sets of ecological traits may differ in their dispersal ability, so a new minimum distance of 100 m between pairs of traps is suggested to minimize interference between baited pitfall traps for sampling copronecrophagous Scarabaeinae dung beetles.
Abstract: A primary goal of community ecologists is to understand the processes underlying the spatiotemporal patterns of species distribution. Understanding the dispersal process is of great interest in ecology because it is related to several mechanisms driving community structure. We investigated the mobility of dung beetles using mark-release-recapture technique, and tested the usefulness of the current recommendation for interaction distance between baited pitfall traps in the Brazilian Atlantic Forest. We found differences in mean movement rate between Scarabaeinae species, and between species with different sets of ecological traits. Large-diurnal-tunneler species showed greater mobility than did both large-nocturnal tunneler and roller species. Our results suggest that, based on the analyses of the whole community or the species with the highest number of recaptured individuals, the minimum distance of 50 m between pairs of baited pitfall traps proposed roughly 10 years ago is inadequate. Dung beetle species with different sets of ecological traits may differ in their dispersal ability, so we suggest a new minimum distance of 100 m between pairs of traps to minimize interference between baited pitfall traps for sampling copronecrophagous Scarabaeinae dung beetles.
145 citations
Authors
Showing all 28762 results
Name | H-index | Papers | Citations |
---|---|---|---|
Richard Vidal | 113 | 685 | 61464 |
Carlos A. Peres | 101 | 434 | 33582 |
Pedro J. J. Alvarez | 89 | 378 | 34837 |
Hans J. Herrmann | 87 | 999 | 30760 |
Elson Longo | 86 | 1454 | 40494 |
Anthony H. Dickenson | 86 | 353 | 24982 |
Kannan Govindan | 83 | 309 | 23633 |
João B. Calixto | 81 | 460 | 23029 |
Walter Herzog | 79 | 672 | 23816 |
Alírio E. Rodrigues | 79 | 832 | 28848 |
Domenico Girelli | 72 | 349 | 23968 |
Larry Davidson | 69 | 459 | 20177 |
Diogo O. Souza | 68 | 534 | 17793 |
David Kirk | 67 | 303 | 14177 |
Felipe Dal-Pizzol | 65 | 380 | 13171 |