Institution
Universidade Federal de Santa Catarina
Education•Florianópolis, Brazil•
About: Universidade Federal de Santa Catarina is a education organization based out in Florianópolis, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 28408 authors who have published 55433 publications receiving 714461 citations.
Papers published on a yearly basis
Papers
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TL;DR: The anthocyanin pigments consist of two or three chemical units: an aglycon base or flavylium ring (anthocyanidin), sugars, and possibly acylating groups.
Abstract: Anthocyanins belong to a large group of secondary plant metabolites collectively known as flavonoids, a subclass of the polyphenol family. They are a group of very efficient bioactive compounds that are widely distributed in plant food. Anthocyanins occur in all plant tissues, including leaves, stems, roots, flowers, and fruits. Research on phenolic compounds through the last century, from the chemical, biochemical, and biological points of view, has focused mainly on the anthocyanins. Anthocyanins have structures consisting of two aromatic rings linked by three carbons in an oxygenated heterocycle (i.e., a chromane ring bearing a second aromatic ring in position 2). The basic chromophore of anthocyanins is the 7-hydroxyflavilyum ion. Anthocyanin pigments consist of two or three chemical units: an aglycon base or flavylium ring (anthocyanidin), sugars, and possibly acylating groups. Only six of the different anthocyanidins found in nature occur frequently and are of dietary importance: cyanidin, delphinid...
201 citations
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Universidade Federal de Minas Gerais1, University of São Paulo2, Universidade Federal de Pelotas3, Federal University of Bahia4, University of Leicester5, Washington University in St. Louis6, Universidade Federal de Santa Catarina7, University of Ferrara8, Johns Hopkins University9, University of Toronto10, Innsbruck Medical University11, Leidos12, University of London13, Oswaldo Cruz Foundation14
TL;DR: It is shown that ancestry-positive assortative mating permeated Brazilian history and shows that continental admixture rather than local post-Columbian history is the main and complex determinant of the individual amount of deleterious genotypes.
Abstract: While South Americans are underrepresented in human genomic diversity studies, Brazil has been a classical model for population genetics studies on admixture. We present the results of the EPIGEN Brazil Initiative, the most comprehensive up-to-date genomic analysis of any Latin-American population. A population-based genome-wide analysis of 6,487 individuals was performed in the context of worldwide genomic diversity to elucidate how ancestry, kinship, and inbreeding interact in three populations with different histories from the Northeast (African ancestry: 50%), Southeast, and South (both with European ancestry >70%) of Brazil. We showed that ancestry-positive assortative mating permeated Brazilian history. We traced European ancestry in the Southeast/South to a wider European/Middle Eastern region with respect to the Northeast, where ancestry seems restricted to Iberia. By developing an approximate Bayesian computation framework, we infer more recent European immigration to the Southeast/South than to the Northeast. Also, the observed low Native-American ancestry (6–8%) was mostly introduced in different regions of Brazil soon after the European Conquest. We broadened our understanding of the African diaspora, the major destination of which was Brazil, by revealing that Brazilians display two within-Africa ancestry components: one associated with non-Bantu/western Africans (more evident in the Northeast and African Americans) and one associated with Bantu/eastern Africans (more present in the Southeast/South). Furthermore, the whole-genome analysis of 30 individuals (42-fold deep coverage) shows that continental admixture rather than local post-Columbian history is the main and complex determinant of the individual amount of deleterious genotypes.
200 citations
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TL;DR: It is demonstrated that the anti-inflammatory effect of BCP involves CB2 and the PPARγ pathway and suggest BCP as a possible therapy for the treatment of inflammatory bowel disease.
Abstract: Cannabinoid receptor 2 (CB2) activation is suggested to trigger the peroxisome proliferator-activated receptor-γ (PPARγ) pathway, and agonists of both receptors improve colitis. Recently, the plant metabolite ( E )-β-caryophyllene (BCP) was shown to bind to and activate CB2. In this study, we examined the anti-inflammatory effect of BCP in dextran sulfate sodium (DSS)-induced colitis and analyzed whether this effect was mediated by CB2 and PPARγ. Oral treatment with BCP reduced disease activity, colonic macro- and microscopic damage, myeloperoxidase and N -acetylglucosaminidase activities, and levels and mRNA expression of colonic tumor necrosis factor-α, IL-1β, interferon-γ, and keratinocyte-derived chemokine. BCP treatment also inhibited the activation of extracellular signal-regulated kinase 1/2, nuclear factor κB, IκB-kinase α/β, cAMP response element binding and the expression of caspase-3 and Ki-67. Moreover, BCP enhanced IL-4 levels and forkhead box P3 mRNA expression in the mouse colon and reduced cytokine levels (tumor necrosis factor-α, keratinocyte-derived chemokine, and macrophage-inflammatory protein-2) in a culture of macrophages stimulated with lipopolysaccharide. The use of the CB2 antagonist AM630 or the PPARγ antagonist GW9662 significantly reversed the protective effect of BCP. Confirming our results, AM630 reversed the beneficial effect of BCP on pro-inflammatory cytokine expression in IEC-6 cells. These results demonstrate that the anti-inflammatory effect of BCP involves CB2 and the PPARγ pathway and suggest BCP as a possible therapy for the treatment of inflammatory bowel disease.
200 citations
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TL;DR: In this paper, the mediating role played by Organizational Learning (OL) capabilities at different contextualization levels on the association between Industry 4.0 (I4.0) technologies and operational performance was examined.
200 citations
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TL;DR: In this article, the authors identify air movement acceptability levels inside naturally ventilated buildings in Brazil and find that the minimal air velocity required were at least 0.4 m/s for 26 °C reaching 0.9 m/m for operative temperatures up to 30 °C.
200 citations
Authors
Showing all 28762 results
Name | H-index | Papers | Citations |
---|---|---|---|
Richard Vidal | 113 | 685 | 61464 |
Carlos A. Peres | 101 | 434 | 33582 |
Pedro J. J. Alvarez | 89 | 378 | 34837 |
Hans J. Herrmann | 87 | 999 | 30760 |
Elson Longo | 86 | 1454 | 40494 |
Anthony H. Dickenson | 86 | 353 | 24982 |
Kannan Govindan | 83 | 309 | 23633 |
João B. Calixto | 81 | 460 | 23029 |
Walter Herzog | 79 | 672 | 23816 |
Alírio E. Rodrigues | 79 | 832 | 28848 |
Domenico Girelli | 72 | 349 | 23968 |
Larry Davidson | 69 | 459 | 20177 |
Diogo O. Souza | 68 | 534 | 17793 |
David Kirk | 67 | 303 | 14177 |
Felipe Dal-Pizzol | 65 | 380 | 13171 |