Showing papers by "Universidade Federal de Santa Catarina published in 2014"
Nicholas J Kassebaum1, Amelia Bertozzi-Villa1, Megan Coggeshall1, Katya Anne Shackelford1 +349 more•Institutions (179)
TL;DR: Global rates of change suggest that only 16 countries will achieve the MDG 5 target by 2015, with evidence of continued acceleration in the MMR, and MMR was highest in the oldest age groups in both 1990 and 2013.
1,383 citations
Christopher J L Murray1, Katrina F Ortblad1, Caterina Guinovart1, Stephen S Lim1 +367 more•Institutions (179)
TL;DR: The Global Burden of Disease 2013 study provides a consistent and comprehensive approach to disease estimation for between 1990 and 2013, and an opportunity to assess whether accelerated progress has occured since the Millennium Declaration.
875 citations
TL;DR: It is found that cells derived via directed differentiation more closely resemble their in vivo counterparts than products of direct conversion, as reflected by the establishment of target cell-type gene regulatory networks (GRNs).
477 citations
Spanish National Research Council1, National Autonomous University of Mexico2, National Institute of Astrophysics, Optics and Electronics3, Complutense University of Madrid4, Autonomous University of Madrid5, Universidade Federal de Santa Catarina6, University of St Andrews7, University of La Laguna8, Instituto Superior Técnico9, Leibniz Institute for Astrophysics Potsdam10, Academy of Sciences of the Czech Republic11, Masaryk University12, Max Planck Society13, University of Sydney14, Australian Astronomical Observatory15, University of Porto16
TL;DR: In this paper, the authors presented the largest and most homogeneous catalog of H ii regions and associations compiled so far, consisting of more than 7000 ionized regions, extracted from 306 galaxies observed by the CALIFA survey.
Abstract: We present the largest and most homogeneous catalog of H ii regions and associations compiled so far The catalog comprises more than 7000 ionized regions, extracted from 306 galaxies observed by the CALIFA survey We describe the procedures used to detect, select, and analyze the spectroscopic properties of these ionized regions In the current study we focus on characterizing of the radial gradient of the oxygen abundance in the ionized gas, based on the study of the deprojecteddistribution of H ii regions We found that all galaxies without clear evidence of an interaction present a common gradient in the oxygen abundance, with a characteristic slope of α_O/H = −01 dex/r_e between 03 and 2 disk effective radii (r_e), and a scatter compatible with random fluctuations around this value, when the gradient is normalized to the disk effective radius The slope is independent of morphology, the incidence of bars, absolute magnitude, or mass Only those galaxies with evidence of interactions and/or clear merging systems present a significantly shallower gradient, consistent with previous results The majority of the 94 galaxies with H ii regions detected beyond two disk effective radii present a flattening in the oxygen abundance The flattening is statistically significant We cannot provide a conclusive answer regarding the origin of this flattening However, our results indicate that its origin is most probably related to the secular evolution of galaxies Finally, we find a drop/truncation of the oxygen abundance in the inner regions for 26 of the galaxies All of them are non-interacting, mostly unbarred Sb/Sbc galaxies This feature is associated with a central star-forming ring, which suggests that both features are produced by radial gas flows induced by resonance processes Our result suggests that galaxy disks grow inside-out, with metal enrichment driven by the local star formation history and with a small variation galaxy-by-galaxy At a certain galactocentric distance, the oxygen abundance seems to be correlated well with the stellar mass density and total stellar mass of the galaxies, independently of other properties of the galaxies Other processes, such as radial mixing and inflows/outflows seem to have a limited effect on shaping of the radial distribution of oxygen abundances, although they are not ruled out
474 citations
TL;DR: The findings suggested that benralizumab 20 mg and 100 mg resided at the dose-response plateau, which was designed with a two-sided α of 0·2 and powered at 78% for the primary outcome in the eosinophilic population.
439 citations
TL;DR: This study shows that, even in high-diversity systems, such as tropical reefs, functional diversity remains highly vulnerable to species loss.
Abstract: When tropical systems lose species, they are often assumed to be buffered against declines in functional diversity by the ability of the species-rich biota to display high functional redundancy: i.e., a high number of species performing similar functions. We tested this hypothesis using a ninefold richness gradient in global fish faunas on tropical reefs encompassing 6,316 species distributed among 646 functional entities (FEs): i.e., unique combinations of functional traits. We found that the highest functional redundancy is located in the Central Indo-Pacific with a mean of 7.9 species per FE. However, this overall level of redundancy is disproportionately packed into few FEs, a pattern termed functional over-redundancy (FOR). For instance, the most speciose FE in the Central Indo-Pacific contains 222 species (out of 3,689) whereas 38% of FEs (180 out of 468) have no functional insurance with only one species. Surprisingly, the level of FOR is consistent across the six fish faunas, meaning that, whatever the richness, over a third of the species may still be in overrepresented FEs whereas more than one third of the FEs are left without insurance, these levels all being significantly higher than expected by chance. Thus, our study shows that, even in high-diversity systems, such as tropical reefs, functional diversity remains highly vulnerable to species loss. Although further investigations are needed to specifically address the influence of redundant vs. vulnerable FEs on ecosystem functioning, our results suggest that the promised benefits from tropical biodiversity may not be as strong as previously thought.
371 citations
TL;DR: Dutra et al. as discussed by the authors examined 263 relativistic-mean-field (RMF) models in a comparable approach and provided a new insight into application of RMF models to properties of nuclear matter and brought into focus their problematic proliferation.
Abstract: Background: The microscopic composition and properties of infinite hadronic matter at a wide range of densities and temperatures have been subjects of intense investigation for decades. The equation of state (EoS) relating pressure, energy density, and temperature at a given particle number density is essential for modeling compact astrophysical objects such as neutron stars, core-collapse supernovae, and related phenomena, including the creation of chemical elements in the universe. The EoS depends not only on the particles present in the matter, but, more importantly, also on the forces acting among them. Because a realistic and quantitative description of infinite hadronic matter and nuclei from first principles in not available at present, a large variety of phenomenological models has been developed in the past several decades, but the scarcity of experimental and observational data does not allow a unique determination of the adjustable parameters.Purpose: It is essential for further development of the field to determine the most realistic parameter sets and to use them consistently. Recently, a set of constraints on properties of nuclear matter was formed and the performance of 240 nonrelativistic Skyrme parametrizations was assessed [M. Dutra et al., Phys. Rev. C 85, 035201 (2012)] in describing nuclear matter up to about three times nuclear saturation density. In the present work we examine 263 relativistic-mean-field (RMF) models in a comparable approach. These models have been widely used because of several important aspects not always present in nonrelativistic models, such as intrinsic Lorentz covariance, automatic inclusion of spin, appropriate saturation mechanism for nuclear matter, causality, and, therefore, no problems related to superluminal speed of sound in medium.Method: Three different sets of constraints related to symmetric nuclear matter, pure neutron matter, symmetry energy, and its derivatives were used. The first set (SET1) was the same as used in assessing the Skyrme parametrizations. The second and third sets (SET2a and SET2b) were more suitable for analysis of RMF and included, up-to-date theoretical, experimental and empirical information.Results: The sets of updated constraints (SET2a and SET2b) differed somewhat in the level of restriction but still yielded only 4 and 3 approved RMF models, respectively. A similarly small number of approved Skyrme parametrizations were found in the previous study with Skyrme models. An interesting feature of our analysis has been that the results change dramatically if the constraint on the volume part of the isospin incompressibility $({K}_{\ensuremath{\tau},\mathrm{v}})$ is eliminated. In this case, we have 35 approved models in SET2a and 30 in SET2b.Conclusions: Our work provides a new insight into application of RMF models to properties of nuclear matter and brings into focus their problematic proliferation. The assessment performed in this work should be used in future applications of RMF models. Moreover, the most extensive set of refined constraints (including nuclear matter and finite-nuclei-related properties) should be used in future determinations of new parameter sets to provide models that can be used with more confidence in a wide range of applications. Pointing to reasons for the many failures, even of the frequently used models, should lead to their improvement and to the identification of possible missing physics not included in present energy density functionals.
347 citations
TL;DR: In this paper, the effects of biodiversity change on selected ecosystem services are evaluated and the authors suggest ways to further understand the links between biodiversity change and ecosystem services, including forage, timber, fisheries, climate regulation, agricultural pest control, and water quality.
Abstract: Understanding when biodiversity conservation and ecosystem-service maintenance are compatible is needed within the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES). Here, we evaluate current understanding and uncertainties of the effects of biodiversity change on selected ecosystem services and suggest ways to further understand the links between biodiversity change and ecosystem services. We reviewed experiments, observations, and syntheses on the effects of species richness on six ecosystem services: forage, timber, fisheries, climate regulation, agricultural pest control, and water quality. Establishing a direct link from biodiversity to ecosystem-service provision has often been precluded by limited data (i.e., the amount, consistency, or generality of the data) and a mismatch between the variables measured and the final ecosystem service that is relevant to stakeholders. We suggest that encompassing syntheses and a network of interdisciplinary experiments under realistic conditions could fill these gaps and could inform the outcomes of alternative management and policy scenarios within IPBES.
296 citations
TL;DR: Based on the data recorded during each sampling campaign, including the locality, temperature, time of year, and number of individuals collected, several conclusions were drawn about the development of this invasion in southern Brazil.
Abstract: This paper presents the first report of the occurrence of Drosophila suzukii (Diptera: Drosophilidae) in South America. Several samples were collected during various seasons in 2012 and 2013, and a significant number of individuals were obtained and identified. Based on the data recorded during each sampling campaign, including the locality, temperature, time of year, and number of individuals collected, several conclusions were drawn about the development of this invasion in southern Brazil.
273 citations
Leibniz Institute for Astrophysics Potsdam1, European Southern Observatory2, Spanish National Research Council3, University of La Laguna4, Complutense University of Madrid5, Masaryk University6, Max Planck Society7, University of St Andrews8, Heidelberg University9, National Autonomous University of Mexico10, INAF11, University of Vienna12, University of Sydney13, Centre national de la recherche scientifique14, Universidade Federal de Santa Catarina15, Paris Diderot University16, University of Chile17, University of Copenhagen18, Academy of Sciences of the Czech Republic19, National Institute of Astrophysics, Optics and Electronics20, Autonomous University of Madrid21, Royal Military College of Canada22
TL;DR: In this paper, the authors describe the selection procedure and statistical properties of the galaxy sample used by the Calar Alto Legacy Integral Field Area (CALIFA) survey, a public legacy survey of 600 galaxies using integral field spectroscopy.
Abstract: We describe and discuss the selection procedure and statistical properties of the galaxy sample used by the Calar Alto Legacy Integral Field Area (CALIFA) survey, a public legacy survey of 600 galaxies using integral field spectroscopy. The CALIFA "mother sample" was selected from the Sloan Digital Sky Survey (SDSS) DR7 photometric catalogue to include all galaxies with an r-band isophotal major axis between 45 '' and 79 : 2 '' and with a redshift 0 : 005 M-r > -23 : 1 and over a stellar mass range between 10(9.7) and 10(11.4) M-circle dot. In particular, within these ranges, the diameter selection does not lead to any significant bias against - or in favour of - intrinsically large or small galaxies. Only below luminosities of M-r = -19 (or stellar masses < 10(9.7) M-circle dot) is there a prevalence of galaxies with larger isophotal sizes, especially of nearly edge-on late-type galaxies, but such galaxies form < 10% of the full sample. We estimate volume-corrected distribution functions in luminosities and sizes and show that these are statistically fully compatible with estimates from the full SDSS when accounting for large-scale structure. For full characterization of the sample, we also present a number of value-added quantities determined for the galaxies in the CALIFA sample. These include consistent multi-band photometry based on growth curve analyses; stellar masses; distances and quantities derived from these; morphological classifications; and an overview of available multi-wavelength photometric measurements. We also explore different ways of characterizing the environments of CALIFA galaxies, finding that the sample covers environmental conditions from the field to genuine clusters. We finally consider the expected incidence of active galactic nuclei among CALIFA galaxies given the existing pre-CALIFA data, finding that the final observed CALIFA sample will contain approximately 30 Sey2 galaxies.
258 citations
TL;DR: PA was positively and consistently associated with some QoL domains among older individuals, supporting the notion that promoting PA in the elderly may have an impact beyond physical health.
TL;DR: In this paper, the authors present the current status and some trends in enzymatic nano-immobilization, and some applications of nanoimmobilized enzymes are explained as well, considering biodiesel production, esters synthesis and biosensors.
Abstract: Nanostructures are very attractive for enzymatic immobilization processes, since they possess ideal characteristics to equilibrate principal factors which determine biocatalysts efficiency, including specific surface area, mass transfer resistance and effective enzyme loading. A lot of materials are used at nano-size in processes of immobilization, like silica, chitosan, gold, diamond, metals, including graphene and zirconium. The functionalization of these supports is thoroughly studied. The focus of this review is to present the current status and some trends in enzymatic nanoimmobilization. Some applications of nanoimmobilized enzymes are explained in this review as well, considering biodiesel production, esters synthesis and biosensors.
TL;DR: In this paper, the adsorption of lead (Pb 2+ ) onto activated carbon (AC) originating from cow bone, chemically modified with HNO 3, was investigated.
TL;DR: In this article, the authors proposed a seaweed management plan for sustainable harvesting of natural resources in the coastal areas of Europe, Canada and Latin American seaweed aquaculture to ensure environmental, social, and economic values.
Abstract: The European, Canadian, and Latin American seaweed industries rely on the sustainable harvesting of natural resources. As several countries wish to increase their activity, the harvest should be managed according to integrated and participatory governance regimes to ensure production within a long-term perspective. Development of regulations and directives enabling the sustainable exploitation of natural resources must therefore be brought to the national and international political agenda in order to ensure environmental, social, and economic values in the coastal areas around the world. In Europe, Portugal requires an appraisal of seaweed management plans while Norway and Canada have developed and implemented coastal management plans including well-established and sustainable exploitation of their natural seaweed resources. Whereas, in Latin America, different scenarios of seaweed exploitation can be observed; each country is however in need of long-term and ecosystem-based management plans to ensure that exploitation is sustainable. These plans are required particularly in Peru and Brazil, while Chile has succeeded in establishing a sustainable seaweed-harvesting plan for most of the economically important seaweeds. Furthermore, in both Europe and Latin America, seaweed aquaculture is at its infancy and development will have to overcome numerous challenges at different levels (i.e., technology, biology, policy). Thus, there is a need for regulations and establishment of “best practices” for seaweed harvesting, management, and cultivation. Trained human resources will also be required to provide information and education to the communities involved, to enable seaweed utilization to become a profitable business and provide better income opportunities to coastal communities.
TL;DR: A new database of more than 1.6 million samples from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local-scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world is described and assessed.
Abstract: Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species Existing global databases of species’ threat status or population time series are dominated by charismatic species The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project – and avert – future declines We describe and assess a new database of more than 16 million samples from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local-scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world The database contains measurements taken in 208 (of 814) ecoregions, 13 (of 14) biomes, 25 (of 35) biodiversity hotspots and 16 (of 17) megadiverse countries The database contains more than 1% of the total number of all species described, and more than 1% of the described species within many taxonomic groups – including flowering plants, gymnosperms, birds, mammals, reptiles, amphibians, beetles, lepidopterans and hymenopterans The dataset, which is still being added to, is therefore already considerably larger and more representative than those used by previous quantitative models of biodiversity trends and responses The database is being assembled as part of the PREDICTS project (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems – wwwpredictsorguk) We make site-level summary data available alongside this article The full database will be publicly available in 2015
Spanish National Research Council1, Universidade Federal de Santa Catarina2, Leibniz Institute for Astrophysics Potsdam3, University of La Laguna4, INAF5, University of Copenhagen6, Max Planck Society7, University of Vienna8, University of Sydney9, University of Cambridge10, Complutense University of Madrid11, Heidelberg University12
TL;DR: In this article, the authors studied the radial structure of the stellar mass surface density and stellar population age as a function of the total stellar mass and morphology for a sample of 107 galaxies from the CALIFA survey.
Abstract: We have studied the radial structure of the stellar mass surface density (μ∗) and stellar population age as a function of the total stellar mass and morphology for a sample of 107 galaxies from the CALIFA survey. We applied the fossil record method based on spectral synthesis techniques to recover the star formation history (SFH), resolved in space and time, in spheroidal and disk dominated galaxies with masses from 10^9 to 10^12 M_⊙. We derived the half-mass radius, and we found that galaxies are on average 15% more compact in mass than in light. The ratio of half-mass radius to half-light radius (HLR) shows a dual dependence with galaxy stellar mass; it decreases with increasing mass for disk galaxies, but is almost constant in spheroidal galaxies. In terms of integrated versus spatially resolved properties, we find that the galaxy-averaged stellar population age, stellar extinction, and μ_∗ are well represented by their values at 1 HLR. Negative radial gradients of the stellar population ages are present in most of the galaxies, supporting an inside-out formation. The larger inner (≤1 HLR) age gradients occur in the most massive (10^11 M_⊙) disk galaxies that have the most prominent bulges; shallower age gradients are obtained in spheroids of similar mass. Disk and spheroidal galaxies show negative μ∗ gradients that steepen with stellar mass. In spheroidal galaxies, μ∗ saturates at a critical value (~7 × 10^2 M_⊙/pc^2 at 1 HLR) that is independent of the galaxy mass. Thus, all the massive spheroidal galaxies have similar local μ_∗ at the same distance (in HLR units) from the nucleus. The SFH of the regions beyond 1 HLR are well correlated with their local μ_∗, and follow the same relation as the galaxy-averaged age and μ_∗; this suggests that local stellar mass surface density preserves the SFH of disks. The SFH of bulges are, however, more fundamentally related to the total stellar mass, since the radial structure of the stellar age changes with galaxy mass even though all the spheroid dominated galaxies have similar radial structure in μ_∗. Thus, galaxy mass is a more fundamental property in spheroidal systems, while the local stellar mass surface density is more important in disks.
TL;DR: The results show that ACC deaminase may not only be related to plant growth promotion abilities, but may also play multiple roles in microorganism's developmental processes, and exploring the origin and functioning of this enzyme may be the key in a variety of important agricultural and biotechnological applications.
Abstract: The main objective of this work is the study of the phylogeny, evolution and ecological importance of the enzyme 1-aminocyclopropane-1-carboxylate (ACC) deaminase, the activity of which represents one of the most important and studied mechanisms used by plant growth–promoting microorganisms. The ACC deaminase gene and its regulatory elements presence in completely sequenced organisms was verified by multiple searches in diverse databases, and based on the data obtained a comprehensive analysis was conducted. Strain habitat, origin and ACC deaminase activity were taken into account when analyzing the results. In order to unveil ACC deaminase origin, evolution and relationships with other closely related pyridoxal phosphate (PLP) dependent enzymes a phylogenetic analysis was also performed. The data obtained show that ACC deaminase is mostly prevalent in some Bacteria, Fungi and members of Stramenopiles. Contrary to previous reports, we show that ACC deaminase genes are predominantly vertically inherited in various bacterial and fungal classes. Still, results suggest a considerable degree of horizontal gene transfer events, including interkingdom transfer events. A model for ACC deaminase origin and evolution is also proposed. This study also confirms the previous reports suggesting that the Lrp-like regulatory protein AcdR is a common mechanism regulating ACC deaminase expression in Proteobacteria, however, we also show that other regulatory mechanisms may be present in some Proteobacteria and other bacterial phyla. In this study we provide a more complete view of the role for ACC deaminase than was previously available. The results show that ACC deaminase may not only be related to plant growth promotion abilities, but may also play multiple roles in microorganism's developmental processes. Hence, exploring the origin and functioning of this enzyme may be the key in a variety of important agricultural and biotechnological applications.
TL;DR: Montmorillonite clay modified with iron oxide (MtMIO) was prepared for use as an adsorbent of methylene blue dye in this article, where the activation energy of + 19.32 kJ−mol−1 was determined using the Arrhenius equation.
TL;DR: This paper criticizes some ways that VSM has been used, observing that important constraints created by its application must be considered and that when used incorrectly, the tool can lead to mistakes that can cause problems instead of benefits.
Abstract: Value stream mapping (VSM) is an important tool of the lean approach and is used to identify value-adding activities and those considered wasteful of materials and the flow of information and people. However, when not applied correctly, VSM can complicate the identification of waste, lead to misinterpretations and assessment mistakes, and undermine the implementation of future improvements. The purpose of this paper is to investigate the main difficulties and limitations encountered during the construction of current state maps, analysis of the associated causes, and pointing out of guidelines to facilitate the use of VSM to map processes. To do so, a search and evaluation of papers in journals, conferences, theses, and dissertations was conducted, and the articles were categorized according to the field of application (factory floor, supply chain, product development and services) and approach (theoretical or practical). In conclusion, this paper criticizes some ways that VSM has been used, observing that important constraints created by its application must be considered and that when used incorrectly, the tool can lead to mistakes that can cause problems instead of benefits. Considering the problems identified, the paper suggests future works for improving the use of VSM for mapping processes.
TL;DR: It is demonstrated that glyphosate-induced neurotoxicity in immature rats following acute and chronic pesticide exposure might lead to excessive extracellular glutamate levels and consequently to glutamate excitotoxicity and oxidative stress in rat hippocampus.
National Institute of Astrophysics, Optics and Electronics1, University of St Andrews2, University of Granada3, Spanish National Research Council4, National Autonomous University of Mexico5, INAF6, University of Sydney7, Complutense University of Madrid8, Universidade Federal de Santa Catarina9, Academy of Sciences of the Czech Republic10, University of Porto11, Max Planck Society12, Leibniz Institute for Astrophysics Potsdam13
TL;DR: In this paper, a comparative study of the stellar metallicity and age distributions in a sample of 62 nearly face-on, spiral galaxies with and without bars, using data from the CALIFA survey is presented.
Abstract: While studies of gas-phase metallicity gradients in disc galaxies are common, very little has been done towards the acquisition of stellar abundance gradients in the same regions. We present here a comparative study of the stellar metallicity and age distributions in a sample of 62 nearly face-on, spiral galaxies with and without bars, using data from the CALIFA survey. We measure the slopes of the gradients and study their relation with other properties of the galaxies. We find that the mean stellar age and metallicity gradients in the disc are shallow and negative. Furthermore, when normalized to the effective radius of the disc, the slope of the stellar population gradients does not correlate with the mass or with the morphological type of the galaxies. In contrast to this, the values of both age and metallicity at ~2.5 scale lengths correlate with the central velocity dispersion in a similar manner to the central values of the bulges, although bulges show, on average, older ages and higher metallicities than the discs. One of the goals of the present paper is to test the theoretical prediction that non-linear coupling between the bar and the spiral arms is an efficient mechanism for producing radial migrations across significant distances within discs. The process of radial migration should flatten the stellar metallicity gradient with time and, therefore, we would expect flatter stellar metallicity gradients in barred galaxies. However, we do not find any difference in the metallicity or age gradients between galaxies with and without bars. We discuss possible scenarios that can lead to this lack of difference.
TL;DR: In this paper, the implication of glucocorticoid treatment on pancreatic β-cell function, islet function, and glucose homeostasis was considered, and the design of improved GC therapies without diabetogenic effects was discussed.
Abstract: Glucocorticoids (GCs) are broadly prescribed for numerous pathological conditions because of their anti-inflammatory, antiallergic and immunosuppressive effects, among other actions. Nevertheless, GCs can produce undesired diabetogenic side effects through interactions with the regulation of glucose homeostasis. Under conditions of excess and/or long-term treatment, GCs can induce peripheral insulin resistance (IR) by impairing insulin signalling, which results in reduced glucose disposal and augmented endogenous glucose production. In addition, GCs can promote abdominal obesity, elevate plasma fatty acids and triglycerides, and suppress osteocalcin synthesis in bone tissue. In response to GC-induced peripheral IR and in an attempt to maintain normoglycaemia, pancreatic β-cells undergo several morphofunctional adaptations that result in hyperinsulinaemia. Failure of β-cells to compensate for this situation favours glucose homeostasis disruption, which can result in hyperglycaemia, particularly in susceptible individuals. GC treatment does not only alter pancreatic β-cell function but also affect them by their actions that can lead to hyperglucagonaemia, further contributing to glucose homeostasis imbalance and hyperglycaemia. In addition, the release of other islet hormones, such as somatostatin, amylin and ghrelin, is also affected by GC administration. These undesired GC actions merit further consideration for the design of improved GC therapies without diabetogenic effects. In summary, in this review, we consider the implication of GC treatment on peripheral IR, islet function and glucose homeostasis.
TL;DR: The use of selenating reagents has often been limited by a generally bad reputation surrounding selenium toxicity and its potential impact on the environment as discussed by the authors, however, some aspects that will encourage the reader to discover an unexpected "green side" to this element and the chemistry connected with its organic derivatives.
Abstract: Organoselenium chemistry has proven to be a powerful tool for organic synthesis over several decades. Nevertheless, the use of selenating reagents has often been limited by a generally bad reputation surrounding selenium toxicity and its potential impact on the environment. In this review we would like to stress some aspects that will encourage the reader to discover an unexpected “green side” to this element and the chemistry connected with its organic derivatives.
TL;DR: The results of this in vitro study show that digital impressions made with the LavaTM C.O.S. system and its digital workflow are suitable for fabricating four-unit zirconia frameworks, with regard to marginal and internal fit requirements.
Abstract: Objectives The aim of this in vitro study was to evaluate the marginal and internal fit of CAD/CAM-generated four-unit zirconia fixed dental prostheses made with digital and conventional impressions. Materials and method A titanium master model was used. For group conventional impression (CI), 12 polyether impressions of the master model with Impregum TM were made. For group digital impression (DI), 12 digital impressions of the master model using Lava TM C.O.S. system were made. The replica technique was applied. The Mann–Whitney U statisticaltestwasappliedtodetectstatisticaldifferencesbetweenthe groups, in terms of marginal and internal fit. Face-by-face comparisons between groups were also carried out. Results Groups DI and CI presented mean marginal fit of 63.96 and 65.33 μm, respectively, and showed no statistically significantdifference.GroupsDIandCIpresentedsignificantly different internal fit with mean values of 58.46 and 65.94 μm, respectively. Group DI showed statistically significantly lower values for marginal and internal fit on premolar mesial face, and on molar distal and palatal faces. Conclusions Frameworks fabricated from digital and conventional impressions showed clinically acceptable marginal fit. Frameworks fabricated from digital impression demonstrated better internal fit than ones fabricated from conventional impression. Reviewing each retainer face, digital impression showed better marginal and internal fit at the premolar mesial and molar distal faces. Clinical relevance The results of this in vitro study show that digital impressions made with the Lava TM C.O.S. sys
TL;DR: It was demonstrated that it is possible to prepare juices from grapes of new varieties grown in the Northeast of Brazil containing a high content of bioactive compounds and typical characteristics of the tropical viticulture practised in the Sub-middle São Francisco Valley.
TL;DR: The decline of multigear fisheries catches is shown – combining anecdotal and scientific data – as well as changes in environmental perceptions over generations of fishermen, which show both the decline of multi-species fisheries catches and the occurrence of the shifting baseline syndrome.
Abstract: In the last decades, a number of studies based on historical records revealed the diversity loss in the oceans and human-induced changes to marine ecosystems. These studies have improved our understanding of the human impacts in the oceans. They also drew attention to the shifting baseline syndrome and the importance of assessing appropriate sources of data in order to build the most reliable environmental baseline. Here we amassed information from artisanal fishermen's local ecological knowledge, fisheries landing data and underwater visual census to assess the decline of fish species in Southeastern Brazil. Interviews with 214 fishermen from line, beach seine and spearfishing revealed a sharp decline in abundance of the bluefish Pomatomus saltatrix, the groupers Epinephelus marginatus, Mycteroperca acutirostris, M. bonaci and M. microlepis, and large parrotfishes in the past six decades. Fisheries landing data from a 16-year period support the decline of bluefish as pointed by fishermen's local knowledge, while underwater visual census campaigns show reductions in groupers' abundance and a sharp population decline of the Brazilian endemic parrotfish Scarus trispinosus. Despite the marked decline of these fisheries, younger and less experienced fishermen recognized fewer species as overexploited and fishing sites as depleted than older and more experienced fishermen, indicating the occurrence of the shifting baseline syndrome. Here we show both the decline of multigear fisheries catches – combining anecdotal and scientific data – as well as changes in environmental perceptions over generations of fishermen. Managing ocean resources requires looking into the past, and into traditional knowledge, bringing historical baselines to the present and improving public awareness.
TL;DR: In this article, the authors describe how these policies have shaped sub-national interventions with detailed data on land tenure and livelihoods in four REDD+ pilot sites in the Brazilian Amazon.
TL;DR: In this paper, the authors compared the mechanical and thermal properties of lightweight aggregate concrete with two kinds of lightweight aggregates, vermiculite and Expanded Polystyrene (EPS) and using air-entraining agent and superplasticizer admixture.
TL;DR: A solvent- and metal-free method for the synthesis of 3-chalcogenyl-indoles from indoles and diorganyl dichalcogenides using an equivalent amount of DMSO as an oxidant, under catalysis by molecular iodine is described.
Abstract: Herein, we describe a solvent- and metal-free method for the synthesis of 3-chalcogenyl-indoles from indoles and diorganyl dichalcogenides using an equivalent amount of DMSO as an oxidant, under catalysis by molecular iodine. This mild and eco-friendly approach allowed the preparation of a wide range of 3-selenyl- and 3-sulfenyl-indoles in good to excellent yields.