Université catholique de Louvain

About: Université catholique de Louvain is a education organization based out in Louvain-la-Neuve, Belgium. It is known for research contribution in the topics: Population & Catalysis. The organization has 25319 authors who have published 57360 publications receiving 2172080 citations. The organization is also known as: University of Louvain & UCLouvain.

The role of the gut microbiota in energy metabolism and metabolic disease.

Abstract: Obesity is now classically characterized by a cluster of several metabolic disorders, and by a low grade inflammation. The evidence that the gut microbiota composition can be different between healthy and or obese and type 2 diabetic patients has led to the study of this environmental factor as a key link between the pathophysiology of metabolic diseases and the gut microbiota. Several mechanisms are proposed linking events occurring in the colon and the regulation of energy metabolism, such as i.e. the energy harvest from the diet, the synthesis of gut peptides involved in energy homeostasis (GLP-1, PYY...), and the regulation of fat storage. Moreover, the development of obesity and metabolic disorders following a high-fat diet may be associated to the innate immune system. Indeed, high-fat diet feeding triggers the development of obesity, inflammation, insulin resistance, type 2 diabetes and atherosclerosis by mechanisms dependent of the LPS and/or the fatty acids activation of the CD14/TLR4 receptor complex. Importantly, fat feeding is also associated with the development of metabolic endotoxemia in human subjects and participates in the low-grade inflammation, a mechanism associated with the development of atherogenic markers. Finally, data obtained in experimental models and human subjects are in favour of the fact that changing the gut microbiota (with prebiotics and/or probiotics) may participate in the control of the development of metabolic diseases associated with obesity. Thus, it would be useful to find specific strategies for modifying gut microbiota to impact on the occurrence of metabolic diseases.

Requirements engineering in the year 00: a research perspective

Abstract: Requirements engineering (RE) is concerned with the identification of the goals to be achieved by the envisioned system, the operationalization of such goals into services and constraints, and the assignment of responsibilities for the resulting requirements to agents such as humans, devices, and software. The processes involved in RE include: domain analysis, elicitation, specification, assessment, negotiation, documentation, and evolution. Getting high quality requirements is difficult and critical. Recent surveys have confirmed the growing recognition of RE as an area of utmost importance in software engineering research and practice. The paper presents a brief history of the main concepts and techniques developed to date to support the RE task, with a special focus on modeling as a common denominator to all RE processes. The initial description of a complex safety-critical system is used to illustrate a number of current research trends in RE-specific areas such as goal oriented requirements elaboration, conflict management, and the handling of abnormal agent behaviors. Opportunities for goal based architecture derivation are also discussed together with research directions to let the field move towards more disciplined habits.