Université catholique de Louvain

About: Université catholique de Louvain is a education organization based out in Louvain-la-Neuve, Belgium. It is known for research contribution in the topics: Population & Catalysis. The organization has 25319 authors who have published 57360 publications receiving 2172080 citations. The organization is also known as: University of Louvain & UCLouvain.

Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor.

Abstract: Study of the interactions established between the viral glycoproteins and their host receptors is of critical importance for a better understanding of virus entry into cells. The novel coronavirus SARS-CoV-2 entry into host cells is mediated by its spike glycoprotein (S-glycoprotein), and the angiotensin-converting enzyme 2 (ACE2) has been identified as a cellular receptor. Here, we use atomic force microscopy to investigate the mechanisms by which the S-glycoprotein binds to the ACE2 receptor. We demonstrate, both on model surfaces and on living cells, that the receptor binding domain (RBD) serves as the binding interface within the S-glycoprotein with the ACE2 receptor and extract the kinetic and thermodynamic properties of this binding pocket. Altogether, these results provide a picture of the established interaction on living cells. Finally, we test several binding inhibitor peptides targeting the virus early attachment stages, offering new perspectives in the treatment of the SARS-CoV-2 infection.

Islet Function in Offspring of Mothers on Low-Protein Diet During Gestation

Abstract: A low-protein diet (8 vs. 20%) administered during pregnancy affects the structure and function of the endocrine pancreas of the offspring. At 21.5 days of gestation, we reported a reduction of cell proliferation, islet size, islet vascularization, and pancreatic insulin content. In this study, we demonstrated an impairment of insulin secretion of these fetal islets when stimulated in vitro with amino acids such as arginine and leucine. If the offspring is kept on the same low-protein diet during suckling, weaning, and adulthood, fasting insulin levels remain low in the presence of normal blood glucose levels. Glucose tolerance at 70 days is impaired, with lower insulin response. In addition, permanent functional damage seems to be induced in utero by a low-protein diet, because a normal diet given from birth to adulthood does not restore normal insulin response after a glucose challenge. Our experimental results stress the impact of a balanced diet with qualitative and quantitative amino acid composition for the fetal endocrine pancreas to develop normally, without lasting functional and structural consequences in adulthood.

Variations in seasonal rainfall in southern Europe during the present century: Relationships with the North Atlantic Oscillation and the El Nino Southern Oscillation

Abstract: Analysis of data from seventeen rainfall stations in the Iberian Peninsula, Balearic Islands and Northern Africa has revealed significant El Nino-Southern Oscillation (ENSO) signals in Europe. Both North Atlantic Oscillation (NAO) and Southern Oscillation (SO) exert an influence on Iberian climate, but at different temporal and spatial scales. Though most of the peninsula is under NAO influence in winter, some stations in the eastern region show no connection with this phenomenon. The same is found for ENSO, with a positively correlated region appearing in the eastern part of Spain, while the rest of the peninsula remains insensitive. The correlation between ENSO and Iberian rainfall has increased towards the end of the present century, with strong positive signals spanning over half of the area studied. The percentage of springtime variability due to ENSO has similarly increased, reaching up to 50% in certain areas. We also show how there are outstanding climatic sensors of these phenomena such as Lake Gallocanta, which manifests a positive response to ENSO while appears insensitive to NAO. Common long-term patterns are observed between SOI and an inferred lake level series, suggesting a constant influence of the low-frequency component of ENSO throughout the period considered. Lake drying phases every 14 years reflect the impact of this signal, approximately every four ENSO events.

Circular interpretation of bijective transformations in lossless watermarking for media asset management

Abstract: The need for reversible or lossless watermarking methods has been highlighted in the literature to associate subliminal management information with losslessly processed media and to enable their authentication. The paper first analyzes the specificity and the application scope of lossless watermarking methods. It explains why early attempts to achieve reversibility are not satisfactory. They are restricted to well-chosen images, strictly lossless context and/or suffer from annoying visual artifacts. Circular interpretation of bijective transformations is proposed to implement a method that fulfills all quality and functionality requirements of lossless watermarking. Results of several bench tests demonstrate the validity of the approach.