Institution
University of Göttingen
Education•Göttingen, Germany•
About: University of Göttingen is a education organization based out in Göttingen, Germany. It is known for research contribution in the topics: Population & Gene. The organization has 43851 authors who have published 86318 publications receiving 3010295 citations. The organization is also known as: Georg-August-Universität Göttingen & Universität Göttingen.
Topics: Population, Gene, Species richness, Context (language use), Catalysis
Papers published on a yearly basis
Papers
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TL;DR: NRG1/ErbB signaling is markedly different between Schwann cells and oligodendrocytes that have evolved an NRG/ ErbB-independent mechanism of myelination control, and is tested by generating a series of conditional null mutants that completely lack NRG1 beginning at different stages of neural development.
356 citations
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TL;DR: The results indicate that chloroquine targets a pathway for viral activation that is not active in lung cells and is unlikely to protect against the spread of SARS-CoV-2 in and between patients.
Abstract: The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with more than 780,000 deaths worldwide (as of 20 August 2020). To develop antiviral interventions quickly, drugs used for the treatment of unrelated diseases are currently being repurposed to treat COVID-19. Chloroquine is an anti-malaria drug that is used for the treatment of COVID-19 as it inhibits the spread of SARS-CoV-2 in the African green monkey kidney-derived cell line Vero1-3. Here we show that engineered expression of TMPRSS2, a cellular protease that activates SARS-CoV-2 for entry into lung cells4, renders SARS-CoV-2 infection of Vero cells insensitive to chloroquine. Moreover, we report that chloroquine does not block infection with SARS-CoV-2 in the TMPRSS2-expressing human lung cell line Calu-3. These results indicate that chloroquine targets a pathway for viral activation that is not active in lung cells and is unlikely to protect against the spread of SARS-CoV-2 in and between patients.
356 citations
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TL;DR: In this article, a mixed regressive-spatial autoregressive (MSA) model was proposed for spatial land use analysis, which is statistically sound in the presence of spatially dependent data, in contrast with the standard linear model.
356 citations
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TL;DR: In this article, an update of the global fit of the Standard Model electroweak sector to latest experimental results is presented, including new kinematic top quark and W boson mass measurements from the LHC, a $$\sin \!^2\theta ^{\ell }_{\mathrm{eff}}$$ result from the Tevatron, and a new evaluation of the hadronic contribution to $$\alpha (M_Z^2)
Abstract: We present an update of the global fit of the Standard Model electroweak sector to latest experimental results. We include new kinematic top quark and W boson mass measurements from the LHC, a $$\sin \!^2\theta ^{\ell }_{\mathrm{eff}}$$
result from the Tevatron, and a new evaluation of the hadronic contribution to $$\alpha (M_Z^2)$$
. We present tests of the internal consistency of the electroweak Standard Model and updated numerical predictions of key observables. The electroweak data combined with measurements of the Higgs boson coupling strengths and flavour physics observables are used to constrain parameters of two-Higgs-doublet models.
356 citations
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TL;DR: It is shown that interleukin-33 (IL-33), an alarmin released from necrotic cells, is necessary for potent CD8+ T cell responses to replicating, prototypic RNA and DNA viruses in mice and showed that endogenous material, independently of pathogen-derived molecules, are also required for antiviral immunity.
Abstract: Pathogen-associated molecular patterns decisively influence antiviral immune responses, whereas the contribution of endogenous signals of tissue damage, also known as damage-associated molecular patterns or alarmins, remains ill defined. We show that interleukin-33 (IL-33), an alarmin released from necrotic cells, is necessary for potent CD8(+) T cell (CTL) responses to replicating, prototypic RNA and DNA viruses in mice. IL-33 signaled through its receptor on activated CTLs, enhanced clonal expansion in a CTL-intrinsic fashion, determined plurifunctional effector cell differentiation, and was necessary for virus control. Moreover, recombinant IL-33 augmented vaccine-induced CTL responses. Radio-resistant cells of the splenic T cell zone produced IL-33, and efficient CTL responses required IL-33 from radio-resistant cells but not from hematopoietic cells. Thus, alarmin release by radio-resistant cells orchestrates protective antiviral CTL responses.
355 citations
Authors
Showing all 44172 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yang Gao | 168 | 2047 | 146301 |
J. S. Lange | 160 | 2083 | 145919 |
Jens J. Holst | 160 | 1536 | 107858 |
Hans Lassmann | 155 | 724 | 79933 |
Walter Paulus | 149 | 809 | 86252 |
Arnulf Quadt | 135 | 1409 | 123441 |
Elizaveta Shabalina | 133 | 1421 | 92273 |
Ernst Detlef Schulze | 133 | 670 | 69504 |
Mark Stitt | 132 | 456 | 60800 |
Meinrat O. Andreae | 131 | 700 | 72714 |
Teja Tscharntke | 130 | 520 | 70554 |
William C. Hahn | 130 | 448 | 72191 |
Vladimir Cindro | 129 | 1157 | 82000 |
Dave Britton | 129 | 1094 | 84187 |
Johannes Haller | 129 | 1178 | 84813 |