Institution
University of Göttingen
Education•Göttingen, Germany•
About: University of Göttingen is a education organization based out in Göttingen, Germany. It is known for research contribution in the topics: Population & Gene. The organization has 43851 authors who have published 86318 publications receiving 3010295 citations. The organization is also known as: Georg-August-Universität Göttingen & Universität Göttingen.
Topics: Population, Gene, Species richness, Context (language use), Catalysis
Papers published on a yearly basis
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International Agency for Research on Cancer1, Lunenfeld-Tanenbaum Research Institute2, Dartmouth College3, Harvard University4, National Institutes of Health5, University of Cambridge6, University of Copenhagen7, Gentofte Hospital8, Copenhagen University Hospital9, University of Texas MD Anderson Cancer Center10, University of Hawaii11, University of Göttingen12, Vanderbilt University Medical Center13, Case Western Reserve University14, University of Oviedo15, Technion – Israel Institute of Technology16, University of Sheffield17, University of Liverpool18, Radboud University Nijmegen19, Washington State University Spokane20, National Institute of Occupational Health21, BC Cancer Agency22, Nanjing Medical University23, New Generation University College24, University of Pittsburgh25, University of Milan26, Princess Margaret Cancer Centre27, University of Southern California28, Sejong University29, Lund University30, Imperial College London31, Aarhus University32, Prevention Institute33, Fred Hutchinson Cancer Research Center34, Ludwig Maximilian University of Munich35, Technische Universität München36, University Hospital Heidelberg37, Umeå University38, University of Kentucky39, Charles University in Prague40, University of Ostrava41, University of Belgrade42, Nofer Institute of Occupational Medicine43, University of Bergen44, National University of Singapore45, Institute of Cancer Research46, American Cancer Society47, Merck & Co.48, University of British Columbia49, University Medical Center Groningen50, University of Leicester51, National Institute for Health Research52, Amgen53, Research Triangle Park54, Washington University in St. Louis55, Baylor College of Medicine56, Anschutz Medical Campus57, University of Washington58, Centre for Addiction and Mental Health59, University of Toronto60, QIMR Berghofer Medical Research Institute61, Laval University62
TL;DR: 18 susceptibility loci achieving genome-wide significance are identified, including 10 new loci linked with lung cancer overall and six loci associated with lung adenocarcinoma, highlighting the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer.
Abstract: Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.
405 citations
TL;DR: Calcium Cycling in Congestive Heart Failure is described, which shows an inverse relationship between heart failure and serum calcium levels, and the number ofocytes in the blood stream decreases with age.
405 citations
TL;DR: The results show a striking correlation between αS aggregates with impaired β‐structure, neuronal toxicity and behavioural defects, and they establish a tight link between the biophysical properties of multimeric αS species and their in vivo function.
Abstract: The relation of α-synuclein (αS) aggregation to Parkinson's disease (PD) has long been recognized, but the mechanism of toxicity, the pathogenic species and its molecular properties are yet to be identified To obtain insight into the function different aggregated αS species have in neurotoxicity in vivo, we generated αS variants by a structure-based rational design Biophysical analysis revealed that the αS mutants have a reduced fibrillization propensity, but form increased amounts of soluble oligomers To assess their biological response in vivo, we studied the effects of the biophysically defined pre-fibrillar αS mutants after expression in tissue culture cells, in mammalian neurons and in PD model organisms, such as Caenorhabditis elegans and Drosophila melanogaster The results show a striking correlation between αS aggregates with impaired β-structure, neuronal toxicity and behavioural defects, and they establish a tight link between the biophysical properties of multimeric αS species and their in vivo function
404 citations
TL;DR: Studies on the role of particular subtypes at specific developmental stages in lower eukaryotes, but also in vertebrates suggest that specific subtypes of H1 participate in particular systems of gene regulation.
404 citations
TL;DR: In this paper, the authors unterstochten die Kondensation des Dampfes auf kristallinem Quarz bei 4° K erzeugt und ihre Supraleitung sowie das Verhalten des Normalwiderstandes beim Tempern untersucht.
Abstract: Dunne Metallschichten werden durch Kondensation des Dampfes auf kristallinem Quarz bei 4° K erzeugt und ihre Supraleitung sowie das Verhalten des Normalwiderstandes beim Tempern untersucht. Dabei sind deutlich zwei Gruppen zu unterscheiden. Zur einen gehoren die Metalle Aluminium, Zink, Indium, Thallium, Blei, Quecksilber und das schon fruher genau untersuchte Zinn; zur anderen das Gallium und das Wismut. Bei allen Elementen der ersten Gruppe bewirkt die Kondensation bei 4° K einheitlich eine starke Erhohung des Restwiderstandes, die beim Tempern verschwindet. Die Ubergangstemperaturen zur Supraleitung werden ganz verschieden beeinflust. Das AI z. B. zeigt eine Erhohung des Sprungpunktes um den Faktor 2,26, wahrend beim Hg eine Erniedrigung um den Faktor 0,94 auftritt. Dabei ergibt sich ein deutlicher Gang dieser Veranderung mit derDebye-Temperatur. Beim Gallium und Wismut dagegen werden viel starkere Beeinflussungen beobachtet. Die Ubergangstemperatur des Galliumfilmes liegt nach der Kondensation bei 8,4° K, also um nahezu den Faktor 8 hoher als die des normalen Galliums bei 1,07° K. Das in kompakter Form nicht supraleitende Wismut wird durch die abschreckende Kondensation zum Supraleiter mit der uberraschend hohen Ubergangstemperatur von 6° K. Das Verhalten des Normalwiderstandes ist bei diesen Metallen komplizierter. Es tritt beim Tempern auch eine Widerstandszunahme auf, die jedoch mit speziellen Eigenschaften dieser Gitter erklart werden kann. Die sehr scharfen Widerstandsanderungen fuhren zur Vermutung von Gitterumwandlungen.
404 citations
Authors
Showing all 44172 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Yang Gao | 168 | 2047 | 146301 |
| J. S. Lange | 160 | 2083 | 145919 |
| Jens J. Holst | 160 | 1536 | 107858 |
| Hans Lassmann | 155 | 724 | 79933 |
| Walter Paulus | 149 | 809 | 86252 |
| Arnulf Quadt | 135 | 1409 | 123441 |
| Elizaveta Shabalina | 133 | 1421 | 92273 |
| Ernst Detlef Schulze | 133 | 670 | 69504 |
| Mark Stitt | 132 | 456 | 60800 |
| Meinrat O. Andreae | 131 | 700 | 72714 |
| Teja Tscharntke | 130 | 520 | 70554 |
| William C. Hahn | 130 | 448 | 72191 |
| Vladimir Cindro | 129 | 1157 | 82000 |
| Dave Britton | 129 | 1094 | 84187 |
| Johannes Haller | 129 | 1178 | 84813 |