University of Portsmouth

About: University of Portsmouth is a education organization based out in Portsmouth, Portsmouth, United Kingdom. It is known for research contribution in the topics: Population & Galaxy. The organization has 5452 authors who have published 14256 publications receiving 424346 citations. The organization is also known as: Portsmouth and Gosport School of Science and Art & Portsmouth and Gosport School of Science and the Arts.

Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein.

Abstract: The La protein is a conserved component of eukaryotic ribonucleoprotein complexes that binds the 3' poly(U)-rich elements of nascent RNA polymerase III (pol III) transcripts to assist folding and maturation. This specific recognition is mediated by the N-terminal domain (NTD) of La, which comprises a La motif and an RNA recognition motif (RRM). We have determined the solution structures of both domains and show that the La motif adopts an alpha/beta fold that comprises a winged-helix motif elaborated by the insertion of three helices. Chemical shift mapping experiments show that these insertions are involved in RNA interactions. They further delineate a distinct surface patch on each domain-containing both basic and aromatic residues-that interacts with RNA and accounts for the cooperative binding of short oligonucleotides exhibited by the La NTD.

Automated algorithm for mapping regions of cold-air pooling in complex terrain

Abstract: [1] In complex terrain, air in contact with the ground becomes cooled from radiative energy loss on a calm clear night and, being denser than the free atmosphere at the same elevation, sinks to valley bottoms. Cold-air pooling (CAP) occurs where this cooled air collects on the landscape. This article focuses on identifying locations on a landscape subject to considerably lower minimum temperatures than the regional average during conditions of clear skies and weak synoptic-scale winds, providing a simple automated method to map locations where cold air is likely to pool. Digital elevation models of regions of complex terrain were used to derive surfaces of local slope, curvature, and percentile elevation relative to surrounding terrain. Each pixel was classified as prone to CAP, not prone to CAP, or exhibiting no signal, based on the criterion that CAP occurs in regions with flat slopes in local depressions or valleys (negative curvature and low percentile). Along-valley changes in the topographic amplification factor (TAF) were then calculated to determine whether the cold air in the valley was likely to drain or pool. Results were checked against distributed temperature measurements in Loch Vale, Rocky Mountain National Park, Colorado; in the Eastern Pyrenees, France; and in Yosemite National Park, Sierra Nevada, California. Using CAP classification to interpolate temperatures across complex terrain resulted in improvements in root-mean-square errors compared to more basic interpolation techniques at most sites within the three areas examined, with average error reductions of up to 3°C at individual sites and about 1°C averaged over all sites in the study areas.

Ultra-Low Surface Energy Polymers: The Molecular Design Requirements

Abstract: In this Research News contribution, the molecular design requirements for the synthesis of polymeric materials that can be used for the fabrication of readily accessible film structures with ultra-low surface energy characteristics are described.

Rough Set Based Decision Support

Abstract: In this chapter, we are concerned with discovering knowledge from data. The aim is to find concise classification patterns that agree with situations that are described by the data. Such patterns are useful for explanation of the data and for the prediction of future situations. They are particularly useful in such decision problems as technical diagnostics, performance evaluation and risk assessment. The situations are described by a set of attributes, which we might also call properties, features, characteristics, etc. Such attributes may be concerned with either the input or output of a situation. These situations may refer to states, examples, etc. Within this chapter, we will refer to them as objects. The goal of the chapter is to present a knowledge discovery paradigm for multi-attribute and multicriteria decision making, which is based upon the concept of rough sets. Rough set theory was introduced by (Pawlak 1982, Pawlak 1991). Since then, it has often proved to be an excellent mathematical tool for the analysis of a vague description of objects. The adjective vague (referring to the quality of information) is concerned with inconsistency or ambiguity. The rough set philosophy is based on the assumption that with every object of the universe U there is associated a certain amount of information (data, knowledge). This information can be expressed by means of a number of attributes. The attributes describe the object. Objects which have the same description are said to be indiscernible (similar) with respect to the available information.